Judgments about estrogen replacement therapy: the role of age, cognitive abilities, and beliefs.

This study investigated age, cognitive abilities, health beliefs, and other factors in women's judgments about effective treatments for menopause. Women (N = 102) ranging in age from 20 to 79 read a vignette about a woman facing a decision about Estrogen Replacement Therapy (ERT) and then made judgments about what should be done. Participants also completed a battery of questions pertaining to ERT and cognitive abilities. Path-analytic techniques were used to determine the role of specific cognitive abilities and the representation of menopause and its treatment in making judgments about ERT treatments. Cognitive abilities had direct effects on treatment decisions. Education affected the number of perceived options for treatment. Age and education indirectly affected treatment decisions, operating through cognitive abilities. Factors related to the mental representation of menopause had no direct effects and few indirect effects on treatment decisions. Potential mechanisms that can help older adults compensate for declines in cognitive abilities in medical decisions are discussed.     

Critique to “Semantic factors in Negation”

Summary It was argued that Hörmann's hypothesis leading to his study in German negation was based on an inference incompatible with the conception of transformational grammar and that his findings could be more appropriately interpreted in terms of transformational grammar than in terms of storage load and semantic content.     

On sentential anagrams: Making sentences out of words

Perception and production of language often have a problem-solving component to them, and this has not been much studied. The present article describes an exploratory approach to some aspects of production which required college students to reorder sentential anagrams. The main finding was that the number of words to be ordered was the greatest influence on performance, whereas little if any influence was exerted by the grammatical variables studied. Although the problem-solving process does not model all language use, it may model the more creative aspect, in which people try to make nonstandard statements. In contrast to a common current view that sentences are holistic, well-formed linguistic objects in mind, the present work emphasizes the developmental and interactive aspect of language production.This work was supported by Grant A7655 from the National, Research Council of Canada and by Leave Fellowship W 760 174 from Canada Council.     

Processing of visually presented clock times

The encoding and representation of visually presented clock times was investigated in three experiments utilizing a comparative judgment task. Experiment 1 explored the effects of comparing times presented in different formats (clock face, digit, or word), and Experiment 2 examined angular distance effects created by varying positions of the hands on clock faces. In Experiment 3, encoding and processing differences between clock faces and digitally presented times were directly measured. Same/different reactions to digitally presented times were faster than to times presented on a clock face, and this format effect was found to be a result of differences in processing that occurred after encoding. Angular separation also had a limited effect on processing. The findings are interpreted within the framework of theories that refer to the importance of representational codes. The applicability to the data of Bank's semantic-coding theory, Paivio's dual-coding theory, and the levels-of-processing view of memory are discussed.     

Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus

The dentate gyrus (DG) is among the few areas in the mammalian brain where production of new neurons continues in the adulthood. Although its functional significance is not completely understood, several lines of evidence suggest the role of DG neurogenesis in learning and memory. Considering that long-term potentiation (LTP) is a prime candidate for the process underlying hippocampal learning and memory, these results raise the possibility that LTP and neurogenesis are closely related. Here, we investigated whether or not LTP induction in the afferent pathway triggers enhanced proliferation of progenitor cells in the DG. LTP was induced by tetanic stimulation in perforant path-DG synapses in one hemisphere, and the number of newly generated progenitor (BrdU-labeled) cells in the DG was quantified. Compared with the control hemisphere (stimulated with low-frequency pulses), the LTP-induced hemisphere contained a significantly higher number of newly generated progenitor cells in the dorsal as well as ventral DG. When CPP, an NMDA receptor antagonist, was administered, tetanic stimulation neither induced LTP nor enhanced progenitor cell proliferation, indicating that NMDA receptor activation, rather than tetanic stimulation per se, is responsible for enhanced progenitor proliferation in the control animal. Our results show that tetanic stimulation of perforant path sufficient to induce LTP increases progenitor proliferation in adult DG in an NMDA receptor-dependent manner.     

Strategic self-marginalization: the case of psychoanalysis

Marginality is an important concept in the history of science, though it is often used in a manner that presumes marginality to be a static designation. We contend that the dynamics of marginality are crucial to the history of psychoanalysis, a discipline that has moved between dominant and marginal positions. We address psychoanalytic marginality via three specific "cases": the marginalization among Freud and his followers when psychoanalysis was an emergent discipline; the marginality trope in Erich Fromm's popular psychoanalytic writing when psychoanalysis was orthodoxy in American academic psychiatry; and the rhetorical marginality of psychoanalysis in Sweden as psychoanalysis entered a decline within psychiatry. Our aim is to show that marginalization and self-marginalization serve interpersonal, social, and professional strategies.     

Involuntary attention and identification accuracy

Using the spatial cuing paradigm, Prinzmetal, McCool, and Park (2005) made the distinction between voluntary and involuntary attention. They claimed that although accuracy was affected by an informative spatial cue (which controls voluntary attention), it was not affected by a noninformative cue (which controls involuntary attention). We reevaluate two reports that assert that noninformative spatial cues affect accuracy. Dufour (1999) reported that a noninformative auditory cue enhanced visual identification in a conjunction search task. Klein and Dick (2002) reported that, in an RSVP task with visual cues, the cue also enhanced accuracy at short stimulus onset asynchronies. We found that Dufour's results were due to overt orienting (eye movements) rather than to covert attention. The results of Klein and Dick were due either to location uncertainty or to a confounding of the order of stimulus presentation and condition.     

Interpersonal consequences of seeking self-esteem

This study examines the interactive effects of self-esteem, contingencies of self-worth, and ego threat on supportiveness and liking. Targets high or low in self-esteem and academic contingency receive failure test feedback or no evaluative feedback. Then, targets interact with another participant who discloses a personal problem; afterward, both participants complete questionnaires assessing targets' supportiveness and liking. High self-esteem, highly contingent targets feel less supportive and like partners less after interacting under threat than under no threat. Partners, in turn, perceive these targets to be less supportive and less likeable. Low self-esteem, highly contingent targets show the reverse pattern, although these findings do not reach statistical significance. Further analyses reveal that the interpersonal effects of ego threat were caused by threats in a specific domain of contingency (e.g., academics) rather than being a contingent person in general or having external or internal contingent self-worth. Implications for self-esteem and interpersonal processes are discussed.     

Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage

Deletions, translocations, or point mutations in the CREB-binding protein (CBP) gene have been associated with Rubinstein-Taybi Syndrome; a human developmental disorder characterized by retarded growth and reduced mental function. To examine the role of CBP in memory, transgenic mice were generated in which the CaMKII alpha promoter drives expression of an inhibitory truncated CBP protein in forebrain neurons. Examination of hippocampal long-term potentiation (LTP), a form of synaptic plasticity thought to underlie memory storage, revealed significantly reduced late-phase LTP induced by dopamine-regulated potentiation in hippocampal slices from CBP transgenic mice. However, four-train induced late-phase LTP is normal. Behaviorally, CBP transgenic mice exhibited memory deficits in spatial learning in the Morris water maze and deficits in long-term memory for contextual fear conditioning, two hippocampus-dependent tasks. Together, these results demonstrate that CBP is involved in specific forms of hippocampal synaptic plasticity and hippocampus-dependent long-term memory formation.     

Age moderates the link between relationship desire and life satisfaction among singles

Higher desire for a romantic partner has been shown to be associated with lower life satisfaction for singles, but research has not considered whether the strength of this association might vary across age groups. We collected data from single participants (N = 3057) across a broad age range (18 to 75 years of age, mean = 36.12, standard deviation [SD] = 12.34) to examine age as a moderator of the relationship between desire for a partner and singles' life satisfaction. Our results suggest that having greater desire for a partner is associated with lower life satisfaction for older (1 SD above the mean or 48.46 years) versus younger (1 SD below the mean or 23.78 years) individuals. We also found some evidence that this age-dependent association was stronger for women than men. Further, this interaction effect remained largely unchanged controlling for participants' attachment anxiety or avoidance. This study highlights the importance of considering how singlehood may play out differently for individuals at different life stages.