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21.
Kang SY Lee KY Park MJ Kim YC Markelonis GJ Oh TH Kim YC 《Neurobiology of learning and memory》2003,79(1):11-18
We previously reported that a total methanolic extract of the underground part of Angelica gigas Nakai (Umbelliferae) (here-in-after abbreviated AG) significantly inhibited acetylcholinesterase (AChE) activity. We characterized 12 coumarin derivatives including both decursin and decursinol from extracts of AG. In this study, we evaluated the anti-amnestic activity of decursin, a major coumarin constituent isolated from AG, in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg body weight, s.c.). Decursin, when administered to mice at 1 and 5 mg/kg body weight i.p., significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and the Morris water maze test. Moreover, decursin significantly inhibited AChE activity by 34% in the hippocampus of treated mice. These results indicate that decursin may exert anti-amnestic activity in vivo through inhibition of AChE activity in the hippocampus. 相似文献
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Park H Collins DR Turvey MT 《Journal of experimental psychology. Human perception and performance》2001,27(1):32-47
Interlimb coordination is subject to constraints. One major constraint has been described as a tendency for homologous muscle groups to be activated simultaneously. Another has been described as a biasing of limb segments to movement in the same direction. In 2 experiments, the 2 constraints were placed in opposition: In-phase or antiphase contraction of homologous muscles of contralateral limbs produced movement that was spatially antiphase or in-phase, respectively. Probability distributions of relative phase were obtained under manipulations of phase detuning and movement speed. They revealed that the equilibrium and stability of coordination were related, respectively, to spatial relative phase and muscular relative phase. Previously observed spatial and muscular constraints reflect a (possibly very general) factorization of attractor location and attractor strength in the dynamics of interlimb coordination. 相似文献
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Jessica L. Waxler Kelsey E. O’Brien Linda M. Delahanty James B. Meigs Jose C. Florez Elyse R. Park Barbara R. Pober Richard W. Grant 《Journal of genetic counseling》2012,21(5):684-691
Advances in genetic epidemiology have increased understanding of common, polygenic preventable diseases such as type 2 diabetes. As genetic risk testing based on this knowledge moves into clinical practice, we propose that genetic counselors will need to expand their roles and adapt traditional counseling techniques for this new patient set. In this paper, we present a genetic counseling intervention developed for a clinical trial [Genetic Counseling/Lifestyle Change for Diabetes Prevention, ClinicalTrials.gov identifier: NCT01034319] designed to motivate behavioral changes for diabetes prevention. Seventy-two phenotypically high-risk participants received counseling that included their diabetes genetic risk score, general education about diabetes risk factors, and encouragement to participate in a diabetes prevention program. Using two validated genetic counseling scales, participants reported favorable perceived control and satisfaction with the counseling session. Our intervention represents one model for applying traditional genetic counseling principles to risk testing for polygenetic, preventable diseases, such as type 2 diabetes. 相似文献
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Florian van Leeuwen Justin H. Park Ian S. Penton-Voak 《Journal of experimental social psychology》2012,48(6):1385-1388
Studies of social categorization have shown that humans robustly categorize others along dimensions of sex, age, kinship, and coalition. Drawing on a functional perspective, we predicted that humans should also categorize others along the dimension of morality (i.e., violating vs. upholding moral norms). In a study employing the memory confusion paradigm, university undergraduate participants (N = 39) were presented with same-sex targets randomly matched with sentences indicating violation or upholding of moral norms, and with sentences indicating competence or incompetence. Results showed that participants spontaneously categorized along morality but not along competence, suggesting that morality (beyond general valence) may be an important dimension of social categorization. 相似文献
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Behavioral self-handicapping is a strategy used to protect attributions about ability. People behaviorally self-handicap by creating an obstacle to their success so failure is attributed to the obstacle instead of to their ability. Although past research has observed behavioral self-handicapping exclusively in men, the current research revealed a moderator of behavioral self-handicapping in women: growth motivation, which reflects the desire to develop one's abilities and learn from failure. Participants (N = 100) completed a test purportedly predictive of successful careers and relationships, and some were given failure feedback about their performance. Participants could behaviorally self-handicap by choosing to complete another test in a performance-impairing environment. Although men self-handicapped more overall, women self-handicapped more after failure when they were low in growth motivation. These results highlight a novel moderator of behavioral self-handicapping in women. 相似文献
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Jennifer M. Park Omar Rahman Tanya K. Murphy Eric A. Storch 《Infant mental health journal》2012,33(2):163-172
Historically, trichotillomania (TTM) in young children (0–3 years old) generally has been considered to be a benign habit that is clinically distinct from the TTM seen in older children and adults. However, early childhood TTM can be an impairing pathological disorder that merits formal intervention. The present article reviews the extant literature on TTM in young children, highlighting the limited available phenomenological data. We discuss a behavioral approach to conceptualization and treatment, highlighting core intervention strategies in three early childhood TTM cases seen in our clinic. We conclude by discussing areas in need of further empirical attention. 相似文献
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A recently developed method of analytical inverse optimization (ANIO) was used to compute cost functions based on sets of experimental observations in 4-finger pressing tasks with accurate total force and moment production. In different series, feedback on total force and moment was provided using the index finger force at its value, doubled, or halved. Finger force data across different force-moment combinations formed a plane. This allowed reconstructing cost functions as 2nd-order polynomials with linear terms. Changes in the coefficients of the cost function across the 3 series allowed the authors to offer a biomechanical interpretation related to constraints on finger forces with different lever arms. ANIO allows the authors to describe preferred regions within the space of solutions for redundant tasks in terms of cost functions. 相似文献