The memory-impairing effects of septal GABA receptor activation involve GABAergic septo-hippocampal projection neurons

Septal infusions of the gamma-aminobutyric acid (GABA)(A) agonist muscimol impair memory, and the effect likely involves the hippocampus. GABA(A) receptors are present on the perikarya of cholinergic and GABAergic septo-hippocampal (SH) projections. The current experiments determined whether GABAergic SH projections are involved in the memory-impairing effects of septal GABA(A) receptor activation. Experiment 1 tested whether combining septal co-infusions of subeffective doses of muscimol with scopolamine, a drug that selectively influences GABA SH projections, would produce memory deficits. Experiment 2 tested whether hippocampal infusions of a GABA(A) receptor antagonist would block the effects of septal muscimol infusions. Fifteen minutes prior to assessing spontaneous alternation (SA) or training in a multiple trial inhibitory avoidance (CMIA) task, male Sprague-Dawley rats were given septal infusions of vehicle, muscimol, scopolamine, or co-infusions of muscimol with scopolamine, or septal infusions of vehicle or muscimol combined with hippocampal infusions of vehicle or bicuculline. Septal co-infusions of muscimol with scopolamine significantly impaired SA and CMIA. Hippocampal bicuculline infusions blocked deficits produced by septal muscimol infusions in SA and attenuated deficits produced in CMIA. Combined, these findings suggest that GABAergic SH projections are involved in the memory-impairing effects of septal GABA receptor activation.     

Is the Cogmed program effective for youths with attention deficit/hyperactivity disorder under pharmacological treatment?

The primary objective of this study was to examine the effects of the Cogmed training program on working memory among youths 7 to 13 years old, with attention deficit/hyperactivity disorder (ADHD) type and comorbidity controlled for. A secondary objective was to examine the generalization of effects to ADHD symptoms, nonverbal reasoning, attentional and executive functions, inhibition, reading comprehension, and mathematical reasoning. Participants were under pharmacological treatment for ADHD combined type and a comorbidity. They were randomized into an experimental group that received the Cogmed program and an active control group that received a low-intensity comparison version of the training. They were evaluated at three time points: 6 weeks prior to intervention onset (T1), immediately prior to onset (T2), and 1 week following intervention completion (T3). Results indicate no significant effect attributable to the Cogmed program. The fact that participants were on medication at the time of training and evaluation normalized their performances and limited the detection of effects. Moreover, cognitive training did not lead to a reduction in ADHD symptoms or to an improvement in the other cognitive functions measured or in academic performance. The results of this study do not demonstrate the effectiveness of the Cogmed program for youths with ADHD combined type and a comorbidity when they receive the training while under pharmacological treatment.     

Is Minority Stress in the Eye of the Beholder? A Test of Minority Stress Theory with Christians

Studies using minority stress theory have focused on the experiences of numerical and social power minorities, though majority individuals may also perceive themselves to be minorities. We explored minority stress theory among a sample of members of a numerically and socially dominant group: Christians in the USA. Perceiving oneself to be a member of a minority as a Christian was associated with stress indirectly via perceived experiences of faith-based discrimination (i.e., harassment due to being Christian). Being more open about one’s religion moderated the relationship between experiences of faith-based discrimination and stress, such that those who were open about their faith reported a stronger relationship between experiences of faith-based discrimination and stress. These findings indicate that perceptions of minority status are important to understanding stress and have implications for minority/majority dialogues.     

"HIV testing is so gay": the role of masculine gender role conformity in HIV testing among men who have sex with men

Men who have sex with men (MSM) account for more than half of all new cases of HIV infection in the United States. Yet, many MSM are unaware of their HIV serostatus. Consistent with research indicating that gender role conformity impacts health behaviors, this study examined how masculine norms may influence HIV testing among MSM in the United States. Data from 170 self-identified MSM (age M = 46.45, SD = 12.18) of self-reported negative or unknown HIV serostatus living in the United States were used in this study. About half (52%) of participants reported that they had been tested for HIV within the past 12 months; 48% reported that they had not. Logistic regression was used to examine the association between domains of masculine gender role conformity and HIV testing within the past 12 months, controlling for number of sexual partners in the last 12 months. The masculine norm of heterosexual self-presentation (i.e., desire to be perceived by others as heterosexual) was negatively associated with HIV testing (B = -0.74, SE B = 0.36, O.R. = 0.48, 95% CI [0.24, 0.96]), after controlling for the effect of number of sexual partners. Psychologists and other health professionals may remain mindful of potential implications of HIV testing among MSM, including potential for MSM to view HIV testing as an "outing" procedure.     

The Theory of Male Reference Group Identity Dependence: Roles of Social Desirability, Masculinity Ideology, and Collective Identity

Data from 118 college men from the southeastern United States (U.S.) were analyzed using zero-order and partial correlations to test male reference group identity dependence theory’s propositions regarding the relations of male reference group identity attitudes (i.e., no reference group, reference group dependent, reference group nondependent similarity, and reference group nondependent diversity) with traditional masculinity ideology and dimensions of men’s gender-based collective identity (i.e., affirmative evaluation of collective identity, importance of collective identity). Male reference group identity attitudes yielded theoretically-consistent relations with the affirmative evaluation and importance of collective identity. Specifically, the no reference group attitudes were correlated negatively whereas nondependent diversity attitudes were correlated positively with affirmative evaluation; the group dependent attitudes were correlated positively with importance of collective identity; and the nondependent similarity attitudes were correlated positively with both affirmative evaluation of collective identity and the importance of collective identity. This pattern reveals the differential salience of collective identity dimensions in male reference group identity attitudes, suggesting that group dependent attitudes reflect importance of collective identity without an evaluation valence, nondependent diversity attitudes reflect affirmative evaluation whereas the no reference group attitudes reflect nonaffirmative evaluation of collective identity, and nondependent similarity attitudes involve both affirmative evaluation and importance of collective identity. Additional findings added to prior data suggesting reevaluation of the posited role of traditional masculinity ideology in male reference group identity theory. The pattern of findings was not changed by controlling for self-deceptive enhancement and impression management dimensions of social desirability.     

Age and sex differences in children’s spatial search strategies

Male and female children, 3, 4, and 5 years old, searched for a sticker that was hidden in 1 of 15 linearly aligned boxes. Two identical bear-shaped landmarks cued the sticker location, which was always in the middle of 3 boxes that separated the two landmarks. The absolute locations of the landmarks and sticker varied across training trials, but the distance in relation to each other remained constant. Training continued until the child chose the correct box first for 3 consecutive trials or for a maximum of 20 trials. Striking age and sex differences emerged in acquisition: The percentage of children who reached criterion increased over age groups to 100% for the boys but stayed at approximately 20% for the girls. A landmark expansion test (with the landmarks moved farther apart) given to children who met criterion revealed that most of these children chose the middle location.     

Interactive Effects of Psychosocial Stress and Early Pubertal Timing on Youth Depression and Anxiety: Contextual Amplification in Family and Peer Environments

While off-time pubertal development has emerged as a potential risk factor for both symptoms of depression and anxiety in youth, the literature is mixed and inconsistent as to (1) how early versus late pubertal timing confers risk for both boys and girls, (2) if the conferred risk is distinct between symptoms of anxiety and depression, and (3) under what social contexts (e.g., family environment, peer relationships) off-time pubertal development may emerge as a potent risk factor for these symptoms. The present study examined the impact of perceived pubertal timing on symptoms of anxiety and depression in two distinct psychosocial contexts: parent’s perceptions of their own harsh parenting and parent’s perceptions of their child’s peer problems. The sample consisted of 412 parents (M = 38.6 years old, SD = 7.8, 60.4 % mothers) of children between the ages of 8 and 17 (M = 12.13, SD = 2.97, 45.4 % girls). All constructs were assessed by parent reports. Linear multiple regression analyses revealed that the interaction between earlier pubertal timing and greater peer problems was significantly related to higher youth depressive and anxiety symptoms. The interaction between earlier pubertal timing and greater harsh discipline was significantly related to higher youth anxiety but not depressive symptoms. Youth gender did not qualify findings. Results suggest that the contextual amplification process of early pubertal timing may occur in both high stress family and peer environments and impact both girls and boys.     

Pubertal Timing and Youth Internalizing Psychopathology: The Role of Relational Aggression

The current study examined relational aggression as a potential mechanism that explains the association between off-time pubertal development and internalizing problems in youth. Youth gender was also examined as a moderator for the association between these variables. It was hypothesized that early pubertal maturation would be associated with higher levels of relationally aggressive behavior which, in turn, would be associated with elevated levels of internalizing problems. Parents of 372 children between the ages of 8 and 17 were recruited through Amazon’s Mechanical Turk. Parents responded to demographic information about themselves, as well as information about their child’s pubertal timing, relationally aggressive behavior, and anxiety and depressive symptoms. Findings indicated that early pubertal timing was associated with higher levels of anxiety directly, and higher levels of both anxiety and depressive symptoms indirectly through higher levels of relational aggression. In all but one of the pathways examined, gender was not found to moderate the associations between the study variables of interest. This study is the first to examine relational aggression as a mechanism by which early pubertal timing leads to internalizing problems. The findings suggest that relational aggression could be a target for intervention among early developing youth who are at risk for internalizing problems.     

Interrelations between maternal smoking during pregnancy,birth weight and sociodemographic factors in the prediction of early cognitive abilities

Maternal prenatal smoking, birth weight and sociodemographic factors were investigated in relation to cognitive abilities of 1544 children (aged 3.5 years) participating in the Québec Longitudinal Study of Children's Development. The Peabody Picture Vocabulary Test (PPVT) was used to assess verbal ability, the Wechsler Preschool and Primary Scale of Intelligence‐Revised (WPPSI‐R) block design test to assess visuospatial ability, and the Visually Cued Recall (VCR) task to assess short‐term memory. Prenatal smoking was related to performance on the WPPSI‐R, the PPVT, and the VCR, although it did not independently predict any cognitive ability after maternal education was taken into account. Birth weight was a more robust predictor of all outcome measures and independently predicted VCR‐performance. Birth weight interacted significantly with family income and maternal education in predicting visuospatial ability, indicating a greater influence of birth weight under relatively poor socio‐economic conditions. Parenting and family functioning mediated associations between maternal education/family income and cognitive task performance under different birth weight conditions, although there were indications for stronger effects under relatively low birth weight. We conclude that investigations of moderating and mediating effects can provide insights into which children are most at risk of cognitive impairment and might benefit most from interventions. Copyright © 2006 John Wiley & Sons, Ltd.