Clinical Cancer Genetics Disparities among Latinos

The three major hereditary cancer syndromes in Latinos (Hereditary Breast and Ovarian Cancer, Familial Adenomatous Polyposis and Lynch Syndrome) have been shown to exhibit geographic disparities by country of origin suggesting admixture-based disparities. A solid infrastructure of clinical genetics geared towards diagnosis and prevention could aid in reducing the mortality of these cancer syndromes in Latinos. Currently, clinical cancer genetic services in Latin America are scarce. Moreover, limited studies have investigated the mutational spectrum of these cancer syndromes in Latinos resulting in gaps in personalized medicine affecting diagnosis, treatment and prevention. The following commentary discusses available genotype and clinical information on hereditary cancer in Latinos and highlights the limited access for cancer genetic services in Latin America including barriers to genetic testing and alternatives for providing better access to genetic services. In this review, we discuss the status of clinical genetic cancer services for both US Latinos and those Latinos living in Latin America.     

Conversational role influences speech imitation

This study assessed the impact of a conscious imitation goal on phonetic convergence during conversational interaction. Twelve pairs of unacquainted talkers participated in a conversational task designed to elicit between-talker repetitions of the same lexical items. To assess the degree to which the talkers exhibited phonetic convergence during the conversational task, these repetitions were used to elicit perceptual similarity judgments provided by separate sets of listeners. In addition, perceptual measures of phonetic convergence were compared with measures of articulation rates and vowel formants. The sex of the pair of talkers and a talker's role influenced the degree of phonetic convergence, and perceptual judgments of phonetic convergence were not consistently related to individual acoustic-phonetic attributes. Therefore, even with a conscious imitative goal, situational factors were shown to retain a strong influence on phonetic form in conversational interaction.     

Decisional Procrastination: Assessing Characterological and Contextual Variables around Indecision

University students (n = 75; M age = 21.4 years old) and community adults (n = 55: M age = 36.6 years old) completed self-reported measures of decisional procrastination (indecision), character (life satisfaction, meaningful life, and need for cognition), context (place attachment, sense of community, and psychological home) and “cross-over” factors relating character and context (self-identity with possessions, people/thing orientation, and clutter), to provide an ecological understanding of persons who claim indecision. Controlling for social desirability tendencies, indecision was negatively related to all character but none of the context variables. Indecision also was related to both person and thing orientation and clutter. Multiple regression analysis indicated that only need for cognition significantly predicted (negatively) indecision among character, context, and cross-over variable sets. Subjective well-being also predicted indecision with low need for cognition among cross-over variables. Taken together, decisional procrastinators reported too much clutter (stuff), interfering with a positive quality of life and related to character over context and cross-over, ecological variables.     

How to fit and interpret multilevel models using SPSS

Hierarchic or multilevel models are used to analyse data when cases belong to known groups and sample units are selected both from the individual level and from the group level. In this work, the multilevel models most commonly discussed in the statistic literature are described, explaining how to fit these models using the SPSS program (any version as of the 11 th ) and how to interpret the outcomes of the analysis. Five particular models are described, fitted, and interpreted: (1) one-way analysis of variance with random effects, (2) regression analysis with means-as-outcomes, (3) one-way analysis of covariance with random effects, (4) regression analysis with random coefficients, and (5) regression analysis with means- and slopes-as-outcomes. All models are explained, trying to make them understandable to researchers in health and behaviour sciences.     

Interaction in ANOVA: misconceptions

Although interaction in analysis of variance has an unequivocal theoretical meaning (and so it appears in the statistic literature), frequent misconceptions are found in empirical research, which, in many cases, lead to wrong conclusions. In this paper, 150 articles are reviewed: in 12.7% of them, no attention is paid to the interaction (either because it is not analysed or because it is analysed but not discussed); in 79.1%, interaction is studied through simple effects analysis; and only in 8.2% of the cases, interaction is correctly discussed. It could be that psychology researchers tend to analyse and interpret the interaction between factors incorrectly because the most widespread statistic packages (with SPSS in the lead) do not allow performing the comparisons needed to analyse a significant interaction in factorial designs with randomized groups. In order to contribute to eradicating this problem, we herein show how to design some of the linear comparisons that allow isolating the interaction effect, and we explain how to use SPSS to compute these comparisons.     

The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond

For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the "rewarding" impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic DA are undergoing a substantial conceptual restructuring, with the traditional emphasis on hedonia and primary reward yielding to other concepts and lines of inquiry. The present review is focused upon the involvement of nucleus accumbens DA in effort-related choice behavior. Viewed from the framework of behavioral economics, the effects of accumbens DA depletions and antagonism on food-reinforced behavior are highly dependent upon the work requirements of the instrumental task, and DA-depleted rats show a heightened sensitivity to response costs, especially ratio requirements. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related choice behavior. Rats with accumbens DA depletions or antagonism reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and show increased selection of low reinforcement/low cost options. Nucleus accumbens DA and adenosine interact in the regulation of effort-related functions, and other brain structures (anterior cingulate cortex, amygdala, ventral pallidum) also are involved. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as symptoms such as psychomotor slowing, fatigue or anergia in depression and other neurological disorders.     

The effects of age and emotional valence on recognition memory: An ex‐Gaussian components analysis

The aim of this work was to study the effects of valence and age on visual image recognition memory. The International Affective Picture System (IAPS) battery was used, and response time data were analyzed using analysis of variance, as well as an ex‐Gaussian fit method. Older participants were slower and more variable in their reaction times. Response times were longer for negative valence pictures, however this was statistically significant only for young participants. This suggests that negative emotional valence has a strong effect on recognition memory in young but not in old participants. The τ parameter, often related to attention in the literature, was smaller for young than old participants in an ex‐Gaussian fit. Differences on the τ parameter might suggest poorer attentional performance in old participants.     

Entrevista con Julián de Ajuriaguerra

RESUMEN

En esta entrevista Julián de Ajuriaguerra describe su historia científica desde que era interno en hospitales psiquiátricos y alumno de Thomas y Lhermitte, comentando los trabajos que realizó con adultos, ancianos y dementes aunque su interés estuviese desde un principio en los niños. Responde, entre otras, a cuestiones tales como si lo biológico se complementa con lo social en el desarrollo, cómo son los vínculos de los padres con el niño, cuál es su posición respecto al psicoanálisis, si es necesaria la interdisciplinariedad para hacer psicología o qué opina del problema de los estadios. También realiza un balance del estado actual de la psicomotricidad, ejemplifica qué entiende por “diálogo tónico” y explica las diferencias entre los juegos de niños y niñas de siete, ocho y nueve años, admitiendo la distinta organización tónica de los sexos. Por último el autor se centra en el trabajo clínico, ofreciendo sugerencias para aquéllos que empiezan a llevarlo a cabo en España. Los comentarios que Ana María Pardo y Ángel Rivière realizan del autor y su obra introducen esta entrevista.     

Effects of A Dual-Task Intervention in Postural Control and Cognitive Performance in Adolescents

Abstract

The aim was to assess dual- versus single-task training for motor performance and cognitive performance in adolescents. Two experiments were performed. In the first, 30 adolescents were randomized to three groups to determine the effect of dual-task difficulty on postural control: α-scaling and root mean square (RMS). In the second, 20 adolescents were randomized to two groups to determine the effect of dual-task practice to improve working memory. RMS in the post-test was lower than the pre-test in both dual-task groups, while α-scaling was lower in post-test than pre-test only in the high-difficulty dual-task group. A practice effect was observed on the percentage of correct answers only in the dual-task group (p?=?0.035). Thus, dual-task training could enhance motor and cognitive performance more than single-task training.     

Factorial confirmatory models of Ryff's scales in a sample of elderly people

Several recent works have analysed the factorial structure of well-being measures. The aim of our study is to analyse the factorial structure of a widely used well-being scale, Ryff's Scales of Psychological Well-being, but in a specific subpopulation of the Spanish population, the elderly. For this particular subpopulation, the construct of well-being has been employed in most theoretical models that explain quality of life, and its role is therefore pivotal. The sample comprised 169 elderly people (65 years or more), sampled within the Valencian Community. The 54-item version of Ryff's scales was used. An item parcelling process was analytically employed before confirmatory factor analyses, allowing a total of 18 well-being indicators. Confirmatory factor analyses were specified and tested, including all theoretical and empirical solutions found in the literature, either in the general population or in specific populations of different cultural contexts. Goodness-of-fit results were similar to the ones found in the literature. Best solutions were a six-factor model with correlated factors, as defended by the authors, and a five-factor correlated solution, collapsing environmental mastery and self-acceptance into a single factor.