Theory of mind and joint action in Parkinson’s disease

It has been suggested that the Theory of Mind (ToM) may rely on more basic processes of social cognition, such as action control (e.g., joint action), even if little is known about this relationship. The relationship between ToM and joint action can be studied in patients with Parkinson’s disease (PD), because they are characterized not only by a deficit in ToM (and in its cognitive and affective subcomponents) but also by a deficit in the inhibition of competing responses. Sixty PD patients and 60 matched healthy controls (HCs) performed a go/no-go Flanker task in both joint and individual conditions. Cognitive (Advanced Test or AT) and affective (Emotion Attribution Task or EAT) ToM also were measured. Thirty-five PD patients and matched HCs also performed the standard Flanker task, as a control measure. In patients, only individuals with high AT scores exhibited a joint Flanker effect, whereas in HCs the joint effect was found irrespectively of AT score. Patients with low EAT scores showed a greater interference effect than patients with high scores, whereas the opposite pattern was found for HCs. In regression analysis AT and EAT scores predicted the Flanker effect in the joint condition only. In the standard task, both groups showed a Flanker effect. The role of different fronto-striatal circuits, especially in PD patients, could explain the different involvement of cognitive and affective ToM in joint tasks. The Flanker effect is discussed considering the referential coding account and the attention-focus account as possible candidates to explain joint action effects.     

Attentional orienting and awareness: evidence from a discrimination task

We used several cue–target SOAs (100, 500, 1000 ms) and three different degrees of cue predictability (Non-predictive-50%, Predictive-75%, Counter-predictive-25%), to investigate the role of awareness of cue–target predictability on cueing effects. A group of participants received instructions about the informative value of the cue, while another group did not receive such instructions. Participants were able to extract the predictive value of a spatially peripheral cue and use it to orient attention, whether or not specific instructions about the predictive value of the cue were given, and no matter their ability to correctly report it in a post-test questionnaire. In the non-predictive block, bad estimators who received no instructions showed regular cueing effects, while good estimators exhibited smaller and non-significant facilitatory effects at the short SOA and an absence of significant IOR at longer SOAs. However, for the instructions group, the pattern of results reversed.     

Spatial attention and conscious perception: the role of endogenous and exogenous orienting

Attention has often been considered to be a gateway to consciousness (Posner, Proceedings of the National Academy of Sciences of the United States of America, 91(16), 7398–7403, 1994). However, its relationship with conscious perception (CP) remains highly controversial. While theoretical models and experimental data support the role of attention in CP (Chica, Lasaponara, Lupiáñez, Doricchi, &; Bartolomeo, NeuroImage, 51, 1205–1212, 2010; Dehaene, Changeux, Naccache, Sackur, &; Sergent, Trends in Cognitive Sciences, 10, 204–211, 2006; Mack &; Rock, Inattentional blindness, 1998), recent studies have claimed that at least some forms of attention—endogenous or top-down spatial attention—are neither sufficient nor necessary for CP (Koch &; Tsuchiya, Trends in Cognitive Sciences, 11, 16–22, 2007). In the present experiments, we demonstrate the importance of exogenously triggered attention for the modulation of CP. Weak or null effects were instead observed when attention was triggered endogenously. Our data are discussed in the framework of recent neuropsychological models (Dehaene et al., Trends in Cognitive Sciences, 10, 204–211, 2006), postulating that activity within reverberating frontoparietal networks, as colocalized with spatial--orienting systems, is the brain correlate of consciously processed information.     

From models to rules: mechanization of reasoning as a way to cope with cognitive overloading in combinatorial problems

It is hypothesized that the transition from unfamiliar problems to familiar, well-learned problems coincides with the transition from a model-based style of reasoning to a rule-based style of reasoning; model-based style of reasoning helps understanding the problem structure, but can overload working memory when the number of models required increases; rule-based style of reasoning avoids cognitive overloading, at the cost of making individuals liable to mechanization errors. In Experiment 1, the number of models required to respond to a verification task affected response latencies with unfamiliar problems, but not with familiar problems, supporting the initial hypothesis. In Experiment 2, participants were prone to mechanization errors when confronted with slightly modified problems in the late stages of the experiment, supporting the hypothesis that they had developed a reasoning rule in the early stages and were blindly applying it. The findings suggest that model-based reasoning and rule-based reasoning serve different purposes and have different costs and benefits, are both available to human reasoners, and familiarization with a problem may induce the transition from the former to the latter. The findings also suggest that mechanization of reasoning may be the first step along a gradient of decreasing cognitive load, whose end-point is automatization, as discussed in theories of automatization of information processing.     

Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons

Current evidence appoints a central role to cholinergic interneurons in modulating striatal function. Recently, a long-term potentiation (LTP) of synaptic transmission has been reported to occur in these neurons. The relationship between the pattern of cortico/thalamostriatal fibers stimulation, the consequent changes in the intracellular calcium concentration ([Ca2+]i), and the induction of synaptic plasticity was investigated in striatal cholinergic interneurons from a rat corticostriatal slice preparation by means of combined electrophysiological intracellular recordings and microfluorometric techniques. Different protocols of stimulation were considered, varying both the frequency and the duration of the train of stimuli. High-frequency stimulation (HFS) (three trains at 100 Hz for 3 sec, 20-sec interval) induced a rise in [Ca2+]i, exceeding by fivefold the resting level, and caused a LTP of synaptic transmission. Tetanic stimulation delivered at lower frequencies (5-30 Hz) failed to induce long-term changes of synaptic efficacy. The observed elevation in [Ca2+]i during HFS was primarily mediated by L-type high-voltage activated (HVA)-Ca2+ channels, as it was fully prevented by nifedipine. Conversely, blockade of NMDA and AMPA glutamate receptor did not affect either LTP or the magnitude of the [Ca2+]i rise. Interestingly, the pharmacological analysis of the post-tetanic depolarizing postsynaptic potential (DPSP) revealed that LTP was attributable, to a large extent, to the potentiation of the GABA(A)-mediated component. In conclusion, the expression of LTP in striatal cholinergic interneurons is a selective response to a precise stimulation pattern of induction requiring a critical rise in [Ca2+]i.     

Selective attention, inhibition for repeated events and hemispheric specialization

When two visual events appear consecutively in the same spatial location, our response to the second event is slower than to the first. This inhibition for repeated events may reflect a bias toward sampling novel locations, a bias useful for exploring visual space. It has been shown that the left hemisphere is more specialized in selective attentional processes than the right one. The aim of the present experiment was to test if this hemispheric specialization for selective attention may also affect the inhibition for repeated events. For this purpose, we asked 11 normal subjects to perform an identity-based discrimination task in which the target to be detected could appear alone or surrounded by flanking letters, in the left or in the right visual field. Results show that inhibition for repeated events is present only when selective attention is required and when the task is performed in the right specialized visual field.     

Learning first-pass structural attachment preferences with dynamic grammars and recursive neural networks

One of the central problems in the study of human language processing is ambiguity resolution: how do people resolve the extremely pervasive ambiguity of the language they encounter? One possible answer to this question is suggested by experience-based models, which claim that people typically resolve ambiguities in a way which has been successful in the past. In order to determine the course of action that has been "successful in the past" when faced with some ambiguity, it is necessary to generalize over past experience. In this paper, we will present a computational experience-based model, which learns to generalize over linguistic experience from exposure to syntactic structures in a corpus. The model is a hybrid system, which uses symbolic grammars to build and represent syntactic structures, and neural networks to rank these structures on the basis of its experience. We use a dynamic grammar, which provides a very tight correspondence between grammatical derivations and incremental processing, and recursive neural networks, which are able to deal with the complex hierarchical structures produced by the grammar. We demonstrate that the model reproduces a number of the structural preferences found in the experimental psycholinguistics literature, and also performs well on unrestricted text.     

Proof-Theoretic Modal PA-Completeness I: A System-Sequent Metric

This paper is the first of a series of three articles that present the syntactic proof of the PA-completeness of the modal system G, by introducing suitable proof-theoretic objects, which also have an independent interest. We start from the syntactic PA-completeness of modal system GL-LIN, previously obtained in [7], [8], and so we assume to be working on modal sequents S which are GL-LIN-theorems. If S is not a G-theorem we define here a notion of syntactic metric d(S, G): we calculate a canonical characteristic fomula H of S (char(S)) so that _G H (S) and _GL-LIN H, and the complexity of H gives the distance d(S, G) of S from G. Then, in order to produce the whole completeness proof as an induction on this d(S, G), we introduce the tree-interpretation of a modal sequent Q into PA, that sends the letters of Q into PA-formulas describing the properties of a GL-LIN-proof P of Q: It is also a d(*, G)-metric linked interpretation, since it will be applied to a proof-tree T of H with H = char(S) and ( H) = d(S, G).     

A diffusion model for discrimination of temporal numerosity

This paper presents a model for sequential discrimination between the temporal frequencies of two discrete events. The model results from adjoining a theory for continuous estimation of temporal numerosity to a mathematical representation of the response criterion. A simple set of assumptions is used to describe the time evolution of numerosity estimates by a stochastic diffusion process. The predictions of the model are extensively compared to a body of results presented in a previous report, with an emphasis on individual performances. It is shown that a number of response strategies, observed in actual experiments, can be predicted by generalizing the classical notion of a single-valued response threshold to a stochastic, time-varying process.     

Naming the parents of the THOG: Mental representation and reasoning

It was hypothesized that subjects misrepresent the THOG problem by confusing data and hypotheses. An abstract version of the problem in which the given exemplars and the hypothetical ones were designated by two different labels was used in three experiments. Experiment 1 showed that this version elicits a better performance than the standard version of the problem. Experiments 2 and 3 confirmed these results, by ruling out a possible alternative account of the facilitatory effect obtained in Experiment 1. The present results are discussed in relationship to the general issues of content effects and non-consequentialism in reasoning.