The enhancement of retention induced by vasopressin in mice may be mediated by an activation of central nicotinic cholinergic mechanisms.

Immediate post-training subcutaneous administration of lysine vasopressin (LVP, 0.003-1.00 microgram/kg) enhanced retention, whereas the vasopressin antagonist AAVP (0.01-0.30 microgram/kg) impaired it, in male Swiss mice tested 48 h after training in an inhibitory avoidance task. Both effects were dose-dependent. Neither LVP nor AAVP affected response latencies in mice not given the footshock on the training trial. The simultaneous administration of AAVP at a dose (0.01 microgram/kg) which had no effect on retention shifted the dose-response curve of LVP to the right. Nicotine (1.0-30.0 micrograms/kg, sc), a central nicotinic cholinergic agonist, also facilitated retention in a dose-related manner without affecting the retention performance of unshocked mice. The effect of nicotine was prevented by the central acting nicotinic cholinergic receptor antagonist mecamylamine (5 mg/kg, sc.). In contrast, neither hexamethonium (5 mg/kg, sc), a peripheral acting nicotinic receptor blocker, nor atropine (0.5 mg/kg, sc) or methylatropine (0.5 mg/kg, sc), two anticholinergic drugs which are known to act on muscarinic cholinergic receptors, prevented the effect of post-training nicotine. The effects of LVP and nicotine were time-dependent, suggesting that both treatments enhanced retention by influencing post-training processes involved in memory storage. Low doses of nicotine (1.50 microgram/kg, sc) or the central anticholinesterase physostigmine (35 micrograms/kg, sc) and LVP (0.003 microgram/kg, sc), which had no effect on retention when administered alone, produced a synergistic interaction when given together following training. The influence of LVP (0.03 microgram/kg, sc) on retention was prevented not only by AAVP (0.01 microgram/kg, sc) but also by mecamylamine (5 mg/kg, sc), whereas the effects of nicotine (10.0 micrograms/kg, sc) were prevented only by mecamylamine. These results suggest that the enhancement of retention induced by vasopressin is probably due to an activation of central nicotinic cholinergic mechanisms which are critical for memory formation.     

A note on partitioned determinants

A formula for the determinant of a partitioned matrix, possibly with singular submatrices, is derived and applied to some psychometric and numerical problems.     

Generalized eigenvalue problems with positive semi-definite matrices

In a recent paper in this journal McDonald, Torii, and Nishisato show that generalized eigenvalue problems in which both matrices are singular can sometimes be solved by reducing them to similar problems of smaller order. In this paper a more extensive analysis of such problems is used to sharpen and clarify the results of McDonald, Torii, and Nishisato. Possible extensions are also indicated. The relevant mathematical literature is reviewed briefly.     

Demonstration of an aftereffect occurring in the tactile-kinesthetic domain

Summary The aim of this work is the demonstration of a tactile-kinesthetic aftereffect. A sequence of stimuli was offered to adult subjects whose task was to compare two weights presented simultaneously to both hands by means of a Piéron gravimeter. In Experiment 1 the inspection stimuli consisted of two successive presentations of unequal weights for a period of 2 × 10 s. The test stimuli consisted of two equal weights rapidly following an inspection stimulus. Control stimuli consisting of two equal weights not preceded by an inspection stimulus were interspersed in the sequence. The results obtained confirm the existence of a contrast effect after presentation of an inspection stimulus. In Experiment 2 the inspection stimuli consisted of a single presentation of two unequal weights for a period of 20 s. The results confirm those of the first experiment and provide data enabling the contrast effect obtained to be interpreted as a Köhler-type aftereffect. In order to avoid confusion with the kinesthetic-figural aftereffect, we propose to call the effect demonstrated here the Gravimetric Aftereffect.     

Correctness of Kruskal's algorithms for monotone regression with ties

Kruskal has proposed two modifications of monotone regression that can be applied if there are ties in nonmetric scaling data. In this note we prove Kruskal's conjecture that his algorithms give the optimal least squares solution of these modified monotone regression problems. We also propose another (third) approach for dealing with ties.Comments by Dr. J. B. Kruskal have been most helpful.     

Progress in the Molecular-Genetic Study of Intelligence

ABSTRACT— The past decade has seen a major shift in the genetic study of human intelligence; where classic studies aimed to quantify the heritability of intelligence, current studies aim to dissect this heritability into its molecular-genetic components. Five whole-genome linkage scans have been published in the past year, converging on several chromosomal (or genomic) regions important to intelligence. A handful of candidate genes, some of which lie in these genomic regions, have shown significant association to intelligence and the associations have been replicated in independent samples. Finding genes brings us closer to an understanding of the neurophysiological basis of human cognition. Furthermore, when genes are no longer latent factors in our models but can actually be measured, it becomes feasible to identify those environmental factors that interact and correlate with genetic makeup. This will supplant the long nature–nurture debate with actual understanding.