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81.
Anna Sedda Davide Rivolta Pina Scarpa Michael Burt Elisa Frigerio Gabriele Zanardi Ada Piazzini Katherine Turner Maria Paola Canevini Stefano Francione Giorgio Lo Russo Gabriella Bottini 《Cognitive, affective & behavioral neuroscience》2013,13(3):452-463
The lateralization of emotion processing is currently debated and may be further explored by examining facial expression recognition (FER) impairments in temporal lobe epilepsy (TLE). Furthermore, there is also debate in the literature whether FER deficits in individuals with TLE are more pronounced in the right than in the left hemisphere. Individuals with TLE were tested with an FER task designed to be more sensitive than those classically used to shed light on this issue. A total of 25 right- and 32 left-TLE patients, candidates for surgery, along with controls, underwent an FER task composed of stimuli shown not only at full-blown intensities (100 %), but also morphed to lower-intensity display levels (35 %, 50 %, and 75 %). The results showed that, as compared to controls, right-TLE patients showed deficits in the recognition of all emotional categories. Furthermore, when considering valence, right-TLE patients were impaired only in negative emotion recognition, but no deficits for positive emotions were highlighted in left-TLE patients. Finally, only the right-TLE patients’ impairment was found to be related to the age of epilepsy onset. Our work demonstrates that the FER deficits in TLE span multiple emotional categories and show manifestations dependent on the laterality of the epileptic focus. Taken together, our findings provide the strongest evidence for the right-hemisphere model, but they also partially support the valence model. We suggest that current models are not exhaustive at explaining emotional-processing cerebral control, and further that multistep models should be developed. 相似文献
82.
School-wide behavior management systems can improve academic performance and behavior in middle schools, and they should have positive effects on students with ADHD. Unfortunately, evidence-based, school-wide behavior management systems have not been widely adopted because of problems with feasibility, acceptability, and sustainability. The Deployment-Focused Model of Intervention Development and Testing has been proposed as a promising method of bridging the gap between research and practice settings. A key aspect of the model is to involve the persons most likely to deliver the service (e.g., teachers) in the intervention development process from the very beginning. To illustrate this process, the authors describe the planning and implementation of a school-wide program designed to improve behavior in a public middle school. 相似文献
83.
Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons 下载免费PDF全文
Bonsi P De Persis C Calabresi P Bernardi G Pisani A 《Learning & memory (Cold Spring Harbor, N.Y.)》2004,11(6):755-760
Current evidence appoints a central role to cholinergic interneurons in modulating striatal function. Recently, a long-term potentiation (LTP) of synaptic transmission has been reported to occur in these neurons. The relationship between the pattern of cortico/thalamostriatal fibers stimulation, the consequent changes in the intracellular calcium concentration ([Ca2+]i), and the induction of synaptic plasticity was investigated in striatal cholinergic interneurons from a rat corticostriatal slice preparation by means of combined electrophysiological intracellular recordings and microfluorometric techniques. Different protocols of stimulation were considered, varying both the frequency and the duration of the train of stimuli. High-frequency stimulation (HFS) (three trains at 100 Hz for 3 sec, 20-sec interval) induced a rise in [Ca2+]i, exceeding by fivefold the resting level, and caused a LTP of synaptic transmission. Tetanic stimulation delivered at lower frequencies (5-30 Hz) failed to induce long-term changes of synaptic efficacy. The observed elevation in [Ca2+]i during HFS was primarily mediated by L-type high-voltage activated (HVA)-Ca2+ channels, as it was fully prevented by nifedipine. Conversely, blockade of NMDA and AMPA glutamate receptor did not affect either LTP or the magnitude of the [Ca2+]i rise. Interestingly, the pharmacological analysis of the post-tetanic depolarizing postsynaptic potential (DPSP) revealed that LTP was attributable, to a large extent, to the potentiation of the GABA(A)-mediated component. In conclusion, the expression of LTP in striatal cholinergic interneurons is a selective response to a precise stimulation pattern of induction requiring a critical rise in [Ca2+]i. 相似文献
84.
Taste aversion learning can be established according to two different procedures, concurrent and sequential. For the concurrent task, two different taste stimuli are offered at the same time, one associated with simultaneous intragastric administration of an aversive stimulus and the other associated with physiological saline. This discrimination is learned by sham-lesioned control animals and by animals with lesions in the cerebellar cortex but not by rats lesioned in the inferior olive. At the same time, animals with lesions in the inferior olive and sham-lesioned animals achieve sequential learning when the gustatory stimuli are offered individually during each daily session. The results obtained show that electrolytic lesions in the inferior olive impair acquisition of concurrent learning and are analyzed in terms of an anatomical system consisting of the vagus nerve, inferior olive, and cerebellum, which differentiates between the two modalities of taste aversion learning, concurrent and sequential. 相似文献
85.
The study investigates the newborn's grasping behavior according to the texture property of an object. 22 full term healthy newborns were tested with their right hand. Eleven babies were exposed to a first condition in which the spontaneous manual activity on an object with a smooth texture was recorded. Eleven babies were exposed to an another condition: they hold the very same object than those presented in the baseline condition except that thin pearls were added on its surface, increasing its roughness. The results provide evidence for the existence of a modulation of hand activity according to the texture property of the object. The nature of this modulatory capacity of the hand is discussed. 相似文献
86.
Gabriele Miceli Carlo Caltagirone Guido Gainotti Paola Payer-Rigo 《Brain and language》1978,6(1):47-51
A phoneme discrimination test based upon CCVC (consonant-consonant-vowel-consonant) syllables was administered to 36 aphasics, 91 brain-damaged subjects, and 42 normal controls, in normal listening conditions. Errors in the discrimination of voice and place contrasts were determined, and the scores (voice-minus-place errors) obtained by the four experimental groups were compared statistically. Aphasic patients, when compared with the other groups, show a greater difficulty in discriminating place than voice contrasts. Some implications of these findings are discussed. 相似文献
87.
Marianna Frascarelli Tommaso Accinni Antonino Buzzanca Luca Carlone Francesco Ghezzi Antonella Moschillo Georgios D. Kotzalidis Paola Bucci Giulia Maria Giordano Martina Fanella Carlo Di Bonaventura Carolina Putotto Bruno Marino Massimo Pasquini Massimo Biondi Fabio Di Fabio 《Journal of Neuropsychology》2023,17(3):564-583
Patients with the 22q11.2 deletion syndrome (DS) show an increased risk of developing a psychotic illness lifetime. 22q11.2DS may represent a reliable model for studying the neurobiological underpinnings of schizophrenia. The study of social inference abilities in a genetic condition at high risk for psychosis, like 22q11.2DS, may shed light on the relationships between neurocognitive processes and patients' daily general functioning. The study sample consisted of 1736 participants, divided into four groups: 22q11.2DS patients with diagnosis of psychotic disorder (DEL SCZ, N = 20); 22q11.2DS subjects with no diagnosis of psychosis (DEL, N = 43); patients diagnosed with schizophrenia without 22q11.2DS (SCZ, N = 893); and healthy controls (HC, N = 780). Social cognition was assessed through The Awareness of Social Inference Test (TASIT) and general functioning through the Specific Levels of Functioning (SLoF) scale. We analysed data through regression analysis. The SCZ and DEL groups had similar levels of global functioning; they both had significantly lower SLoF Total scores than HC (p < .001); the DEL SCZ group showed significantly lower scores compared to the other groups (SCZ, p = .004; DEL, p = .003; HC, p < .001). A significant deficit in social cognition was observed in the three clinical groups. In the DEL SCZ and SCZ groups, TASIT scores significantly predicted global functioning (p < .05). Our findings of social cognition deficit in psychosis-prone patients point to the possible future adoption of rehabilitation programmes, like Social Skills Training and Cognitive Remediation, during premorbid stages of psychosis. 相似文献
88.
Association between chemosensory stimuli and cesarean delivery in rat fetuses: neonatal presentation of similar stimuli increases motor activity 总被引:1,自引:0,他引:1
Recent studies conducted in this laboratory indicated that prenatal chemosensory stimulation followed by cesarean delivery strongly affected postnatal responsiveness to odors derived from the administered substances. The present experiments were performed in order to examine if an associative process was responsible for such effects. In Experiment 1 rat fetuses during Gestational Day 21 were exposed to a tenuous alcohol solution or to a lemon-containing solution either 40 or 10 min prior to cesarean delivery. All subjects were subsequently tested in terms of changes in neonatal motor activity when confronted with the odor of alcohol or lemon. Rats experiencing prenatal cues 10 min prior to delivery exhibited higher and differential responsiveness to the smell of these cues when compared to those experiencing similar solutions 40 min prior to delivery. In Experiment 2 each fetus sequentially experienced both cues. Subsequent tests confirmed that the delay between prenatal sensory experience and birth induction was critical in terms of significantly affecting olfactory-mediated motor responses. The results suggest that consequences related with cesarean delivery act as an unconditioned stimulus capable of being associated with orosensory cues present in the amniotic fluid. 相似文献
89.
Paola Bernabei Gabriel Levi Eleonora Camillo Maria Di Falco 《Infant mental health journal》1996,17(1):81-88
The authors present the first part of a study on children with BHS (Breath Holding Spells) syndrome. These children were chosen in order to examine a “pathological” situation in infancy that was as close as possible to a “normal” one, and in which obvious somatic symptoms were associated with emotional states. Children with BHSS are not considered to have serious psychological disturbances, even if they are constantly referred to as intolerant of separation, stubborn, oppositional, or easy to temper tantrum. A reduced ability to tolerate frustration is evident in these children both from the patients' history and clinical observation. Parents usually relate BHS to situations in which the child is denied something or gets scolded. The children were observed during three sessions, both with and without the mother, according to a grid used at our Center. Patients are presented to illustrate certain recurrent features in play and interaction with mother. The data suggest that these children stagnate in an area of incomplete mental representation; something makes them oscillate between two states; in one of them, the mental representation of the object and of the bond with it is possible; in the other, the mental representation of the separation, which entails the recognition of the object, is felt as dangerous. 相似文献
90.