Parenting and Family Stress Treatment Outcomes in Attention Deficit Hyperactivity Disorder (ADHD): An Empirical Analysis in the MTA Study

Parenting and family stress treatment outcomes in the MTA study were examined. Male and female (579), 7–9-year-old children with combined type Attention Deficit Hyperactivity Disorder (ADHD), were recruited at six sites around the United States and Canada, and randomly assigned to one of four groups: intensive, multi-faceted behavior therapy program alone (Beh); carefully titrated and monitored medication management strategy alone (MedMgt); a well-integrated combination of the two (Comb); or a community comparison group (CC). Treatment occurred over 14 months, and assessments were taken at baseline, 3, 9, and 14 months. Parenting behavior and family stress were assessed using parent-report and child-report inventories. Results showed that Beh alone, MedMgt alone, and Comb produced significantly greater decreases in a parent-rated measure of negative parenting, Negative/Ineffective Discipline, than did standard community treatment. The three MTA treatments did not differ significantly from each other on this domain. No differences were noted among the four groups on positive parenting or on family stress variables. Results are discussed in terms of the theoretical and empirically documented importance of negative parenting in the symptoms, comorbidities and long-term outcomes of ADHD.     

Spatial learning in rats is impaired by microinfusions of protein kinase C-gamma antisense oligodeoxynucleotide within the nucleus accumbens

The nucleus accumbens (NAcc) has been shown to play a role in motor and spatial learning. Protein kinase C (PKC) has been implicated in the mechanisms of initiation and maintenance of long-term potentiation that is thought to be involved in the storage of long-term memory. In the present study, the importance of de novo synthesis of PKC-gamma within the NAcc in the acquisition and retention of spatial discrimination learning was assessed using an antisense knockdown approach. Separate groups of Long-Evans rats were exposed to acute microinfusions (6microg/microl) of PKC-gamma antisense oligodeoxynucleotide (AS-ODN), control oligodeoxynucleotide (C-ODN) or vehicle into the NAcc at 24 and 3h before each training session. Behavioral findings showed that the blockade of NAcc-PKC-gamma translation caused impairments in the early phase of learning and retention of spatial information. Biochemical experiments showed that PKC-gamma expression was reduced and Ca(2+)/phospholipid-dependent protein kinase C (PKC) activity was blocked significantly in the AS-ODN-treated rats in comparison with control rats. The present findings suggest that NAcc-PKC-gamma plays a role during the early acquisition of spatial learning. Also, retention test results suggest that NAcc-PKC-gamma may be working as an intermediate factor involved in the onset of molecular mechanisms necessary for spatial memory consolidation within the NAcc.     

"外部性"问题与"科斯定理"的伦理追问

"外部性"是新制度经济学理论中探讨的一个重要问题.为了解决这个问题,新制度经济学家提出了"科斯定理".什么是"外部性",为什么外部性问题既是一个经济问题又是一个伦理问题,从经济伦理的角度怎么看待"科斯定理"?这是本文所要讨论的问题.     

转向生活世界的伦理学变革

转向生活世界的伦理学变革,使当代伦理学研究从对普遍化的道德原理和道德体系的知识论建构转向对以现代性问题为背景的现实生活世界的道德关切.在这种变革中,当代伦理学研究实现着从体系意识向问题意识的转变,引发了应用伦理学的勃兴和德性伦理传统的当代复兴,从而使伦理学的人学价值意蕴得以彰显.当代伦理学的发展还需要在此基础上,进一步面向现实生活世界,实现问题意识与理论意识的互动、德性伦理与规范伦理的整合、道德共识与差异伦理的和谐.     

3-6岁幼儿在分类实验中概括能力的发展

本研究通过设计不同性质的分类实验,探讨3-6岁幼儿抽象概括能力的发展。我们根据年龄将幼儿分为四个组,每组80人,共320人。通过实验获得以下几点。①幼儿在各种不同性质的分类实验中可表现为四级不同的水平,如从根据表面的个别特征进行分类发展到根据内部的本质特征进行分类,从一维角度的分类发展到从两维角度来分类等。⑦达到各个水平的年龄不是截然划分的,而是互相交织的,随着年龄的增加,低级水平的人数不断减少,高级水平的人数不断增加。所以年龄阶段之间既有质的变化,又有量的变化。③对于不同性质的分类材料,各年龄所达到的概括水平也不同,分类材料的难度越大,概括水平越低。④儿童概括水平的高低受教育条件的影响。     

Intergroup contact can undermine disadvantaged group members' attributions to discrimination

In the current research we investigated social settings through which attributions to discrimination are undermined. Drawing on work linking intergroup contact to perceptions of inequality, we tested the prediction that experiences of commonality-focused contact would reduce disadvantaged group members' tendency to attribute negative treatment of fellow group members to discrimination. In Study 1 students were randomly assigned to either a commonality-focused, differences-focused, or no-contact condition, ostensibly with a student from a higher status university. Commonality-focused interactions led participants to view the status hierarchy as more legitimate, and consequently, to be less likely to attribute negative treatment to discrimination. In Study 2 this effect was replicated among Ethiopian-Jews (a disadvantaged minority in Israel) who reported the amount of commonality-focused contact they experience with non-Ethiopian Jews. Theoretical and practical implications regarding intergroup contact and perceptions of inequality are discussed.     

Peer Rejection and Friendships in Children with Attention-Deficit/Hyperactivity Disorder: Contributions to Long-Term Outcomes

Even after evidence-based treatment, Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with poor long-term outcomes. These outcomes may be partly explained by difficulties in peer functioning, which are common among children with ADHD and which do not respond optimally to standard ADHD treatments. We examined whether peer rejection and lack of dyadic friendships experienced by children with ADHD after treatment contribute to long-term emotional and behavioral problems and global impairment, and whether having a reciprocal friend buffers the negative effects of peer rejection. Children with Combined type ADHD (N?=?300) enrolled in the Multimodal Treatment Study of Children with ADHD (MTA) were followed for 8 years. Peer rejection and dyadic friendships were measured with sociometric assessments after the active treatment period (14 or 24 months after baseline; M ages 9.7 and 10.5 years, respectively). Outcomes included delinquency, depression, anxiety, substance use, and general impairment at 6 and 8 years after baseline (Mean ages 14.9 and 16.8 years, respectively). With inclusion of key covariates, including demographics, symptoms of ADHD, ODD, and CD, and level of the outcome variable at 24 months, peer rejection predicted cigarette smoking, delinquency, anxiety, and global impairment at 6 years and global impairment at 8 years after baseline. Having a reciprocal friend was not, however, uniquely predictive of any outcomes and did not reduce the negative effects of peer rejection. Evaluating and addressing peer rejection in treatment planning may be necessary to improve long-term outcomes in children with ADHD.     

Can survival processing enhance story memory? Testing the generalizability of the adaptive memory framework

Research from the adaptive memory framework shows that thinking about words in terms of their survival value in an incidental learning task enhances their free recall relative to other semantic encoding strategies and intentional learning (Nairne, Pandeirada, & Thompson, 2008). We found similar results. When participants used incidental survival encoding for a list of words (e.g., "Will this object enhance my survival if I were stranded in the grasslands of a foreign land?"), they produced better free recall on a surprise test than did participants who intentionally tried to remember those words (Experiment 1). We also found this survival processing advantage when the words were presented within the context of a survival or neutral story (Experiment 2). However, this advantage did not extent to memory for a story's factual content, regardless of whether the participants were tested by cued recall (Experiment 3) or free recall (Experiments 4-5). Listening to a story for understanding under intentional or incidental learning conditions was just as good as survival processing for remembering story content. The functionalist approach to thinking about memory as an evolutionary adaptation designed to solve reproductive fitness problems provides a different theoretical framework for research, but it is not yet clear if survival processing has general applicability or is effective only for processing discrete stimuli in terms of fitness-relevant scenarios from our past.     

THE DEVELOPMENT OF FALSE‐POSITIVE OUTCOMES DURING FUNCTIONAL ANALYSES OF PROBLEM BEHAVIOR

False‐positive outcomes of functional analyses exist when exposure to the consequences in a condition strengthens a relation that did not previously exist. Two functional analyses (aggression and spitting) were conducted with a child with an intellectual disability. High rates of problem behavior occurred immediately in the attention condition of the functional analysis across response topographies, suggesting a clear functional response class. However, rates of aggression and spitting increased in the demand condition, following the initial block of sessions, indicating the possible creation of a novel contingent relation for spitting. Copyright © 2014 John Wiley & Sons, Ltd.