Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors

In rats, pretraining ip administration of the central benzodiazepine receptor antagonist, flumazenil (5.0 mg/kg), or of the inverse agonist, n-butyl-beta-carboline-3-carboxylate (BCCB) (0.2 or 0.5 mg/kg), facilitated retention of a step-down inhibitory avoidance task; the central agonists, clonazepam and diazepam (0.4 or 1.0 mg/kg), had an opposite effect, and the peripheral agonist, 4'-chlordiazepam (1.25 or 6.25 mg/kg), was without effect. Pre- but not post-training flumazenil (2.0 mg/kg) blocked the effect of BCCB (0.5 mg/kg), clonazepam (1.0 mg/kg), or diazepam (1.0 mg/kg) given also pretraining. The post-training administration of all of these drugs had no effect on retention of the avoidance task. Flumazenil (5.0 mg/kg) and BCCB (0.5 mg/kg), given before training, enhanced retention test performance of habituation to a buzzer but not of habituation to an open field. In the three tasks studied, none of the drugs used had any appreciable effect on training session parameters. These results suggest that there is an endogenous mechanism mediated by benzodiazepine agonists, sensitive to inverse agonists, that normally down-regulates acquisition of certain behaviors; this mechanism becomes activated only when the tasks involve or occur with a certain degree of stress or anxiety (i.e., inhibitory avoidance or habituation to the buzzer) and not in less stressful or anxiogenic tasks (i.e., habituation to an open field).     

Effects of Level of Processing on Implicit and Explicit Memory in Depressed Mood

Recently, several studies have addressed the question of whether depression affects priming in implicit memory tasks. The main aim of this experiment was to assess the presence of a bias for negative information in explicit memory (free recall) and implicit memory (word-stem completion) tasks among subclinically depressed subjects compared to nondepressed subjects, using the typical levels of processing manipulation. The results of this study show the existence of a mood-congruent memory bias for both implicit and explicit memory in depressed subjects. The theoretical implications of these findings for implicit and explicit memory biases associated with depressed mood are discussed.     

Implicit learning: Below the subjective threshold

In this review, we consider three possible criteria by which knowledge might be regarded as implicit or inaccessible: It might be implicit only in the sense that it is difficult to articulate freely, or it might be implicit according to either an objective threshold or a subjective threshold. We evaluate evidence for these criteria in relation to artificial grammar learning, the control of complex systems, and sequence learning, respectively. We argue that the convincing evidence is not yet in, but construing the implicit nature of implicit learning in terms of a subjective threshold is most likely to prove fruitful for future research. Furthermore, the subjective threshold criterion may demarcate qualitatively different types of knowledge. We argue that (1) implicit, rather than explicit, knowledge is often relatively inflexible in transfer to different domains, (2) implicit, rather than explicit, learning occurs when attention is focused on specific items and not underlying rules, and (3) implicit learning and the resulting knowledge are often relatively robust.     

Modeling the body temperature throughout the day with a two-term function

A two-term function with potential and exponential terms is proposed to model the body temperature throughout the day. These terms can be related to thermogenic and thermolytic processes that are opposite but simultaneous. The first term, a potential function, reflects that the heat gain process is predominant; the second term is a negative exponential function and reflects the predominance of heat dissipation. The function also provides the time of the inflection between thermal opposite processes. The proposed two-term function and a cosine function were fitted to 335 temperature series of 24-h duration recorded in humans and animals. The percentage of variance accounted for by the two-term function was higher than that for the cosine approximation for the total sample and for those series whose shape was asymmetrical (n=75). Nevertheless, no significant differences between the percentage of variance accounted for by the two functions were found for those series whose shape was symmetrical (n=260). The results of different subgroups that differed in experimental conditions are discussed.     

Heading and path information from retinal flow in naturalistic environments

In four experiments, we explored the heading and path information available to observers as we simulated their locomotion through a cluttered environment while they fixated an object off to the side. Previously, we presented a theory about the information available and used in such situations. For such a theory to be valid, one must be sure of eye position, but we had been unable to monitor gaze systematically; in Experiment 1, we monitored eye position and found performance best when observers fixated the designated object at the center of the display. In Experiment 2, when we masked portions of the display, we found that performance generally matched the amount of display visible when scaled to retinal sensitivity. In Experiments 3 and 4, we then explored the metric of information about heading (nominal vs. absolute) available and found good nominal information but increasingly poor and biased absolute information as observers looked farther from the aimpoint. Part of the cause for this appears to be that some observers perceive that they have traversed a curved path even when taking a linear one. In all cases, we compared our results with those in the literature.     

Is visual attention automatically attracted by one’s own name?

Subjects were presented with briefly exposed visual displays of words that were common first names with a length of four to six letters. In the main experiment, each display consisted of four words: two names shown in red and two shown in white. The subject’s task was to report the red names (targets), but ignore the white ones (distractors). On some trials the subject’s own name appeared as a display item (target or distractor). Presentation of the subject’s name as a distractor caused no more interference with report of targets than did presentation of other names as distractors. Apparently, visual attention was not automatically attracted by the subject’s own name.     

Fuzzy Logic and Arithmetical Hierarchy,II

A very simple many-valued predicate calculus is presented; a completeness theorem is proved and the arithmetical complexity of some notions concerning provability is determined.