“被精神病”现象的解构与消弭

“被精神病”现象严重侵害了公民基本人权、危害了社会公共安全.其产生的根源在于权力的泛滥、权利的漠置、程序的单一和监督的缺失.要根治这一现象,必须尽快加强法制建设和程序完善,加强事前鉴定和事后监督,加强异议申诉和司法救济,完善精神卫生统一立法,有效监督行政权力,保障公民正当权利.     

转化医学体系下的学科服务模式探讨

转化医学的出现极大地推动了医学研究模式的变革,同时转化医学模式对服务于医学研究的图书馆也带来了机遇和挑战,通过对转化医学实现路径的分析,发掘出转化医学研究的实际需求,结合目前学科馆员服务面临的困境,从中寻找出适应转化医学模式的学科服务模式,从而为开展进一步的工作打下良好的基础.     

《管子》的民生思想及其对建设服务型政府的启示

《管子》是战国时期一本重要的治国理论著作,它包含着深刻的民生思想,告诫君主要坚持以民为本,才能国强民富,赢得民心,进而实现治理国家的目标。本文从利民、富民、顺民和爱民四个方面对《管子》的民生思想进行剖析,概括《管子》民生思想的精髓。这一研究可以为我国服务型政府建设提供启示和借鉴。     

贝伐单抗治疗实体肿瘤的临床研究进展

血管内皮生长因子(vascular endothelial growth factor,VEGF)在肿瘤的发病机制中起着关键作用,其作为抗肿瘤治疗的重要靶点,已得到越来越多的关注.贝伐单抗(Bevacizumab,BEV)是一种血管内皮生长因子的单克隆抗体,是目前最受关注的分子靶向药物之一,自2004年经美国FDA批准上市以来,BEV已被用于多种实体肿瘤的治疗.本文就BEV关于治疗几类实体肿瘤的临床研究进展作一综述.     

Evolving team cognition: The impact of team situation models on team effectiveness

The current research examined a moderated mediation model for the relationships among indicators of objective career success (salary and job level), subjective career success (career satisfaction), and turnover intention, as well as the boundary conditions of this process. Based on a survey study among a sample of Chinese managers (N = 324), we found that both salary and job level were negatively related to turnover intention, with these relations fully mediated by career satisfaction. The results further showed that the relation between job level and career satisfaction was weaker among managers who perceived a higher level of organizational career management, but stronger among managers with a higher managerial career anchor. In support of our hypothesized model, the indirect effect of job level on turnover intention through career satisfaction existed only among managers who perceived a lower level of organizational career management or managers with a higher managerial career anchor. These findings carry implications for research on career success and turnover intention.     

A New Procedure to Test Mediation With Missing Data Through Nonparametric Bootstrapping and Multiple Imputation

This article proposes a new procedure to test mediation with the presence of missing data by combining nonparametric bootstrapping with multiple imputation (MI). This procedure performs MI first and then bootstrapping for each imputed data set. The proposed procedure is more computationally efficient than the procedure that performs bootstrapping first and then MI for each bootstrap sample. The validity of the procedure is evaluated using a simulation study under different sample size, missing data mechanism, missing data proportion, and shape of distribution conditions. The result suggests that the proposed procedure performs comparably to the procedure that combines bootstrapping with full information maximum likelihood under most conditions. However, caution needs to be taken when using this procedure to handle missing not-at-random or nonnormal data.     

Spoken word recognition in context: evidence from Chinese ERP analyses

Two event-related potential (ERP) experiments were conducted to investigate spoken word recognition in Chinese and the effect of contextual constraints on this process. In Experiment 1, three kinds of incongruous words were formed by altering the first, second or both syllables of the congruous disyllabic terminal words in high constraint spoken sentences. Results showed an increase of N400 amplitude in all three incongruous word conditions and a delayed N400 effect in the cohort incongruous condition as compared with the rhyme incongruous and plain incongruous condition. In addition, unlike results in English, we found that the N400 effect in the rhyme incongruous condition disappeared earlier than in the plain incongruous condition. In Experiment 2, three kinds of nonwords derived from sentence congruous words were constructed by altering few or many phonetic features of the onset or the whole of the first syllable, and the resulting nonwords appeared as disyllabic terminal forms in either high or low constraint sentences. All three nonword conditions elicited the N400 component. In addition, in high constraint sentences but not in low, the amplitude and duration of the N400 varied as a function of the degree of phonetic mismatch between the terminal nonword and the expected congruous word.     

义势两辨荣辱相分——荀子荣辱观及其当代启示

荀子是中国古代第一个系统论述荣辱观的思想家,他在<正论>篇里提出了著名的"义荣"、"势荣"、"义辱"、"势辱"概念.先秦儒家三大代表人物孔子、孟子、荀子在荣辱观问题上的观点是一致的.荣辱观主要通过荣誉感的激励功能与羞耻感的约束功能发挥其道德评价与选择功能.荀子以先义后利为荣,追求内在的义荣的思想为我们当前树立正确的荣辱观提供了有益的启示.     

Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

The perforant path projecting from the entorhinal cortex to the hippocampal dentate gyrus is a particularly vulnerable target to the early deposition of amyloid beta (Abeta) peptides in Alzheimer's brain. The authors previously showed that brief applications of Abeta at subneurotoxic concentrations suppressed the early-phase long-term potentiation (E-LTP) in rat dentate gyrus. The current study further examines the effect of Abeta on the late-phase LTP (L-LTP) in this area. Using multiple high-frequency stimulus trains, a stable L-LTP lasting for at least 3 h was induced in the medial perforant path of rat hippocampal slices. Bath application of Abeta(1-42) (0.2-1.0 microM) during the induction trains attenuated both the initial and late stages of L-LTP. On the other hand, Abeta(1-42) perfusion within the first hour following the induction primarily impaired the late stage of L-LTP, which resembled the action of the protein synthesis inhibitor emetine. Blockade of calcineurin activity with FK506 or cyclosporin A completely prevented Abeta-induced L-LTP deficits. These results suggest that Abeta(1-42) impaired both the induction and maintenance phase of dentate L-LTP through calcineurin-dependent mechanisms. In the concentration range effective for inhibiting L-LTP, Abeta(1-42) also reduced the amplitude of NMDA receptor-mediated synaptic currents in dentate granule cells via a postsynaptic mechanism. In addition, concurrent applications of Abeta(1-42) with the protein synthesis inhibitor caused no additive reduction of L-LTP, indicating a common mechanism underlying the action of both. Thus, inhibition of NMDA receptor channels and disruption of protein synthesis were two possible mechanisms contributing to Abeta-induced L-LTP impairment.