Impairment of spontaneous alternation performance by an NMDA antagonist: attenuation with non-NMDA treatments.

N-Methyl-D-aspartate (NMDA) receptor antagonists disrupt learning on a variety of tasks. Previous findings indicate that glucose, naloxone, and physostigmine ameliorate learning deficits produced by several treatments. The present experiment examines whether these agents also reverse the amnestic effects of NMDA receptor blockade. Mice were tested for spontaneous alternation performance in a Y-maze. The animals received either saline or the NMDA antagonist, NPC 12626 (35 mg/kg, IP), 50 min prior to testing and received an additional injection of saline, glucose, naloxone, or physostigmine 30 min prior to testing. NPC 12626 significantly decreased alternation scores. Glucose (250 mg/kg), physostigmine (0.01 mg/kg), and naloxone (1 mg/kg) reversed the effects of NPC 12626. Thus, impairments of learning after NMDA receptor blockade share with other amnestic conditions the susceptibility to attenuation by glucose, naloxone, and physostigmine.     

Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease.

Although visuoconstructive impairment has been reported in both Alzheimer's (DAT) and Huntington's (HD) disease, there is little knowledge concerning how this cognitive deficit differs quantitatively and qualitatively in these two progressive dementias. To address this issue, the present study compared performances on the Clock Drawing Test (CDT: command and copy) of 25 DAT patients, 25 equally demented HD patients, and 25 elderly normal controls (NC). In the command condition, both patients groups were significantly impaired compared to the NC group. Although there was no significant difference between DAT and HD patients' total quantitative scores, a qualitative error analysis revealed a number of dissociations between the two patient groups. Graphic difficulties, very common in HD patients, were virtually absent in DAT patients; in contrast, conceptual errors were almost exclusively seen in DAT patients and were related to the severity of their dementia. Perseveration and "stimulus-bound" responses were also more frequent in DAT patients, and both groups made visuospatial errors. In the copy condition, the DAT, but not the HD, patients evidenced a marked improvement in performance. These results indicate that while both DAT and HD patients have significant visuoconstructive difficulties even in the early stages of their disorders, the specific cognitive processes underlying their quantitative impairments are quite different. It is possible that the DAT patients' conceptual errors are yet another indicator of the deterioration of their semantic knowledge.     

Remembering pictures: pleasure and arousal in memory.

Incidental memory performance for pictures that varied along the affective dimensions of pleasantness and arousal was assessed. For both an immediate and delayed (1 year later) free-recall task, only the arousal dimension had a stable effect on memory performance: Pictures rated as highly arousing were remembered better than low-arousal stimuli. This effect was corroborated in a speeded recognition test, in which high-arousal materials encoded earlier in the experiment produced faster reaction times than their low-arousal counterparts. Pleasantness affected reaction time decisions only for pictures not encoded earlier. These results suggest that whereas both the dimensions of pleasantness and arousal are processed at initial encoding, long-term memory performance is mainly affected by arousal.     

Computer-Assisted Careers Guidance Systems and Organisational Change

This article describes a study conducted to identify the range of potential influences that a computer-assisted careers guidance system (PROSPECT (HE)) had on the functioning of organisations (careers services in higher education). Data from six institutions indicated that use of PROSPECT (HE) was associated with important and varied change within the organisations. It appears that when a careers service seeks opportunities for change, CACG systems can be an important catalyst for change in two respects: by providing a focal point for achieving previously established goals; or, as a consequence of system use, by making staff aware of the potential for new organisational goals.     

Prominence of girls and boys in the classroom: Schoolchildren's perceptions

Several studies have revealed teachers' asymmetric perceptions of girls and boys in their classes. The present research examines these effects on schoolchildren's own perceptions of the prominence of male and female peers in school relevant categories. A total of 147 (native born, Jewish middle class) second and sixth graders participated in the study. A questionnaire in two versions was prepared: One formulated in the masculine plural, habitually used in Hebrew as the generic plural for both sexes. The other in both masculine and feminine (optional he/she) plural, also admissible in Hebrew usage. Overall, students judged more boys as prominent, even more so in sixth grade. Subjects also pointed to same-sex peers as prominent. Surprisingly, the sex-optional formulation of the questionnaire did not decrease stereotyping perceptions. Results raise questions about the status of girls in school. Implications for girls' future as achievers in modern society are discussed. Furthermore, the effectiveness of language manipulation in Hebrew regarding sexist vs. nonsexist attitudes is put into question.     

The effect of gender and time-of-day on time perception and mental workload

Two experiments are reported which investigated how subject gender and time-of-day influenced the estimation of duration and the perception of task-related mental workload. In the first experiment, 24 subjects performed a filled time-estimation task in a constant blacked-out, noise-reduced environment at 0800h, 1200h, 1600h, and 2000h, respectively. In the second experiment, 12 different subjects performed an unfilled time estimation task in similar conditions at 0900h, 1400h, and 1900h. At the termination of all experimental sessions, participants completed the NASA Task Load Index workload assessment questionnaire as a measure of perceived mental workload. Results indicated that physiological response, reflected in body temperature change, followed an expected pattern of sequential increase with time-of-day. However, estimates of duration and the perception of mental workload showed no significant effects for time-of-day. In each of the experiments there were significant differences in time estimation and mental workload response contingent on the gender of the participant. These results are interpreted in light of the previous positive findings for circadian fluctuation in performance efficiency and the equivocal findings of a gender difference in time estimation. A unifying account of these collective results is given based on gender by time-of-day interactional effects. An earlier version of this paper was presented at the 32nd Annual Meeting of the Human Factors Society, Anaheim, CA, October, 1988.     

Jury selection in two countries: a psychological perspective

A comparative survey of jury selection practices in Britain and the United States indicates that the two countries differ along a number of dimensions, including the emphasis on the jury selection process in the trial, the amount and type of information available about prospective jurors, and the frequency with which trial lawyers alter the composition of the jury. The probable impact of these differences is analysed by considering the importance of jury composition in determining a jury’s verdict, the effectiveness of lawyers in exercising their challenges, and broader effects of jury selection procedures in the two countries.     

Cultural practices of Hispanics: implications for the prevention of AIDS

Hispanic Americans have one of the highest rates of HIV seroprevalence among all ethnics groups in the US, with high rates being especially noticeable among women and children. Were it known which cultural factors have the most influence on whether Hispanics engage in high-risk behavior for HIV transmission, prevention interventions could be targeted accordingly. To that end, this study was mounted to identify which Hispanic cultural factors relate to condom use. 117 males and 73 females aged 17-56 years of mean age 25.67 were surveyed in Washoe county, Nevada. These mostly young adults had recently immigrated to the western US. It was initially posited that fate orientation, male- female relationships, family relationships, machismo behavior, and religion would have equal influence with respect to condom use. Analysis found that condom use was largely associated with and determined by men who are the principal buyers of condoms. A machismo attitude toward protecting women by using condoms was also associated with condom use. Neither fate orientation with respect to AIDS, nor religion were important determinants of condom use, even though 86.5% of the respondents were Catholic. The degree to which respondents adhered to traditional Hispanic cultural values was influenced by the degree of education and acculturation. On the basis of these findings, the authors suggest targeting AIDS prevention messages to males, while emphasizing the protection of women through condom use. They also suggest that both education and acculturation levels be assessed before implementing prevention programs.