Recognition memory for emotional faces in amnestic mild cognitive impairment: An event-related potential study

ABSTRACT

This study examined the temporal course of emotional face recognition in amnestic mild cognitive impairment (aMCI). Patients and healthy controls (HC) performed a face recognition task, giving old/new responses to previously studied and novel faces displaying a negative or neutral expression. In aMCI patients, recognition accuracy was preserved for negative faces. Event-related potentials (ERPs) revealed disease-related changes in early perceptual components but not in ERP indices of explicit recognition. Specifically, aMCI patients showed impaired recognition effects for negative faces on the amplitudes of N170 and P2, suggesting deficient memory-related processing of negative faces at the stage of structural encoding and during an early recognition stage at which faces are individuated, respectively. Moreover, while a right-lateralized emotion effect specifically observed for correctly recognized faces on the amplitude of N170 was absent in aMCI, a similar emotion effect for successfully recognized faces on P2 was preserved in the patients, albeit with a different distribution. This suggests that in aMCI facilitated processing of successfully recognized emotional faces starts later in the processing sequence. Nonetheless, an early frontal old/new effect confined to negative faces and a parietal old/new effect unaffected by facial emotion were observed in both groups. This indicates that familiarity and conceptual priming processes may specifically contribute to recognition of negative faces in older adults and that aMCI patients can recruit the same retrieval mechanisms as controls, despite disease-related changes on early perceptual ERP components.     

Bootstrap Contraction

We can often specify how we would contract by a certain sentence by saying that this contraction would coincide with some other contraction that we know how to perform. We can for instance clarify that our contraction by p&q would coincide with our contraction by p, or by q, or by {p, q}. In a framework where the set of potential outcomes is known, some contractions are “self-evident” in the sense that there is only one serious candidate that can be the outcome of such a contraction. Contraction by a specific contractee (sentence or set of sentences to be contracted) is bootstrapped if it is specified by saying that it coincides with some such self-evident contraction. For a wide range of (multiple) contraction operators, contractions by any contractee can be bootstrapped. This means that the selection mechanism (selection function, incision function, etc.) can be replaced by a function called a bootstrapping selector that assigns to each contractee some “self-evident” contractee that yields the same outcome. With bootstrapping we can eliminate traditional extralogical components in contraction (e.g., selection functions) and replace them by bootstrapping selectors that reflect more closely the ways in which we actually reason and argue about belief contraction.     

Ideal Worlds — Wishful Thinking in Deontic Logic

The ideal world semantics of standard deontic logic identifies our obligations with how we would act in an ideal world. However, to act as if one lived in an ideal world is bad moral advice, associated with wishful thinking rather than well-considered moral deliberation. Ideal world semantics gives rise to implausible logical principles, and the metaphysical arguments that have been put forward in its favour turn out to be based on a too limited view of truth-functional representation. It is argued that ideal world semantics should be given up in favour of other, more plausible uses of possible worlds for modelling normative subject-matter.     

Category-specified Value Statements

A value statement such as “she is a good teacher” is categoryspecified, i.e., the criteria of evaluation are specified as those that are applicable to a given category, in this case the category of teachers. In this study of categoryspecified value statements, certain categories are identified that cannot be used to specify value aspects. Special attention is paid to categories that are constituted by functional characteristics. The logical properties of value statements that refer to such categories are shown to differ significantly from the corresponding properties in social choice theory.     

Local Change

An agent can usually hold a very large number of beliefs. However, only a small part of these beliefs is used at a time. Efficient operations for belief change should affect the beliefs of the agent locally, that is, the changes should be performed only in the relevant part of the belief state. In this paper we define a local consequence operator that only considers the relevant part of a belief base. This operator is used to define local versions of the operations for belief change. Representation theorems are given for the local operators.     

The psychological treatment of memory impairment: A review of empirical studies

Memory impairment is a frequent effect of many different forms of brain dysfunction. Memory impairment is also a frequent focus of treatment interventions, and there have been many different treatment methods suggested. The suggested methods include direct retraining, the use of spared skills in compensating for the impairment (alternate functional systems), and the use of behavioral strategies to circumvent the manifest memory dysfunction (behavioral prosthetics). Unfortunately, there are very few studies comparing the various suggested treatment methods. The present paper evaluates the empirical evidence related to the treatment of memory dysfunction and suggests directions for future investigations. Although the evidence is not conclusive, it appears that some forms of treatment may be helpful in remediating certain types of memory impairment. An approach likely to be productive would include some consideration of the impaired neurological and psychological mechanisms responsible for the manifest memory deficit as well as a consideration of the etiology of the injury thought to be causally related to the memory deficit. As yet, there have been no rigorous empirical evaluations of these considerations.     

Vibrotactile frequency discrimination

Thresholds for vibrotactile discrimination of pulse interval were determined for pulse frequencies between 1 and 384 Hz. The results point to a temporal resolution significantly more accurate than that demonstrated in earlier studies. Although touch as a vibratory sensor is in general much inferior to audition, the present results show a striking resemblance to those obtained on auditory pitch. The neurophysiological implications for the tactile as well as for the auditory system are discussed.     

Uncertainty and the Ethics of Clinical Trials

A probabilistic explication is offered of equipoise and uncertainty in clinical trials. In order to be useful in the justification of clinical trials, equipoise has to be interpreted in terms of overlapping probability distributions of possible treatment outcomes, rather than point estimates representing expectation values. Uncertainty about treatment outcomes is shown to be a necessary but insufficient condition for the ethical defensibility of clinical trials. Additional requirements are proposed for the nature of that uncertainty. The indecisiveness of our criteria for cautious decision-making under uncertainty creates the leeway that makes clinical trials defensible.     

Reading words with irregular decoding rules: A test of premorbid cognitive function?

The present study investigated the relation between level of general cognitive function and the oral reading of irregular words in Swedish. Swedish is an orthographically regular language, so many irregular words are loan words from other languages. A test comprising such words (irregularly spelled words (ISW)) was designed, and tested on a sample of 48 healthy Swedish adults, stratified according to age, gender, and level of education. The results confirmed that the ability to read words that do not follow the regular rules for decoding in Swedish was positively related to general cognitive level. ISW in combination with demographic variables gave a good estimate of general cognitive function and a better estimate than demographic variables alone. Exposure to written and spoken vocabulary during the lifespan may be indexed by ISW performance, for factor analysis suggested that this may constitute a discrete factor contributing to cognitive function.