Evaluation of Breast Cancer Patients with Genetic Risk in a University Hospital: Before and After the Implementation of a Heredofamilial Cancer Unit

The identification of patients at risk for breast cancer by genetic testing has proven to reduce breast cancer mortality. In 2010, due to a lack of systematization in hereditary cancer assistance in our center, we implemented a multidisciplinary Heredofamilial Cancer Unit (HFCU). We analyze if the HFCU improved the rates of referrals and preventive management of breast cancer patients with genetic risk. We retrospectively compared family history records, referrals of high-risk patients to genetic counseling, and detection and management of patients with BRCA1/2 mutations in two cohorts of breast cancer patients diagnosed before (first period: 2007–2010) and after the creation of the HFCU (second period: 2010–2013). In the first period, 893 patients were included, and 902 were included in the second. Due to the inability to establish their genetic risk, 142 patients (15.9%) vs. 70 (7.8%) were excluded from analysis (p?<?0.001). Among the evaluable patients, 194 (25.8%) vs. 223 (26.8%) fulfilled one or more risk criteria (p?=?0.65). Family history documentation in patient’s medical records (92.4 vs. 97.8%, p?<?0.001) and referral rate (26.3 vs. 52%, p?<?0.0001) significantly increased in the second period. Eight BRCA1/2 mutations were detected among patients referred in the first period and 17 among those referred to the HFCU. The rate of preventive surgeries in patients with BRCA mutations significantly increased in the second period (25 vs. 76.5%, p?=?0.03). In conclusion, there was a clear improvement in family history records, referrals, and preventive surgeries in breast cancer patients with genetic risk after the implementation of the HFCU.     

Development of the Spanish short version of Negative Attitudes Toward Masturbation Inventory

Background/Objective: Masturbation has historically been a sexual behaviour associated with negative connotations, as a consequence of traditional orthodox positions, despite its positive impact on health. The instruments developed to measure the attitude towards masturbation are scarce, and none of them have been validated in the Spanish adult population. This study aims to propose a short version of the Negative Attitudes Toward Masturbation Inventory (NATMI) and examine their psychometric properties (reliability and evidence of validity) in the Spanish adult population. Method: A total of 4,116 heterosexual adults aged 18-83 years (M = 40.58; SD = 12.24; 54.64% women) participated in the study. In addition to the NATMI, they answered other scales to assess sexual attitudes, sexual desire, propensity to become sexually excited/inhibited and sexual functioning. Results: Analysis of the construct validity of the NATMI resulted in a reduced version of ten items grouped into a single factor explaining 66% of the variance (ordinal alpha = .95). The evidence of validity is clear, as subjects with negative and positive attitude towards masturbation differed in religiousness, frequency of masturbation, erotophilia, positive attitude towards sexual fantasies, sexual inhibition and sexual functioning. Conclusions: The Spanish short version of NATMI provides reliable and valid measures in the Spanish adult population.     

Young and Old Adults' Concerns About Morality and Competence

Two experiments were conducted to examine people's sensitivity to person information from the morality domain (relation-oriented) and the competence domain (task & achievement-oriented). In a lexical decision paradigm, the findings from Experiment 1 showed that younger adults were faster to identify person cues (trait words) from the morality than from the competence domain, especially cues that were related to immorality. Experiment 2 compared the responses of younger and older adults. Despite the slower responses of the older adults, the findings indicated that all participants were faster at identifying cues from the morality domain than from the competence domain, with no age interactions. The results from Experiment 2 also suggested that disparate findings in the literature regarding reaction times to morality/competence cues and valence (positive or negative) were a function of word frequency effects. The findings are discussed in terms of people's chronic concern with the moral aspects of others as invariant across the lifespan, given that the morality domain is where interpersonal costs and threats are most likely to be signaled.     

The medical context of parental coping with childhood cancer

This research assessed the extent to which contextual factors, especially the medical context, are related to the use of specific coping strategies by 74 parents of surviving children with cancer. Parents reported that they coped reasonably well by using information-seeking, problem-solving, help-seeking, maintaining emotional balance, relying on religion, being optimistic, denying, and accepting. More highly educated parents tended to use problem solving, optimism, and information seeking significantly more and denial significantly less than well-educated parents. However, gender and income were unrelated to coping. The use of specific coping strategies was not related to severity of the child's medical condition, stress level, or parents' own evaluations of their coping effectiveness. However, the quality of relations with the medical staff was strongly related to coping strategies. Use of passive coping strategies was positively related to good relations with the medical staff.     

The word order problem in agrammatism : II. Production

This study demonstrates that agrammatic aphasics have difficulty describing relations that are signified by the order of noun phrases around verbs or prepositions. The word order deficit is found in a Sentence Order Task, in which written words must be arranged linearly to form a sentence, as well as in oral production. Ordering tendencies reflect factors like animacy or potency, rather than the systematic use of syntactic rules. These results point to a fundamental syntactic disorder in agrammatism.     

Cross-national stereotypes of locus of control in university students1

Stereotypes of locus of control were studied in male and female university students from eight countries (Canada, France, West Germany, India, Israel, Italy, Japan, United States). The subjects took the Rotter Internal-External Locus of Control (I-E) Scale in standard fashion (“own” scores) and then in the role of students similar to themselves in their own country (attributed own) and in selected other countries (attributed other). Using the difference between “own” scores and “attributed” scores as the operational measure of stereotype, the results indicate (1) that scores attributed to students in a given country bear little relationship to those students “own” scores, thereby suggesting the presence of stereotypes of locus of control; (2) students in most countries attribute greater externality to the average student in their own country compared to themselves; (3) countries vary in the degree to which they stereotype other countries with the U.S. students significantly attributing greater externality to other countries and Japanese students significantly attributing greater internality to other students; (4) countries vary in the degree to which they are stereotyped with German students perceived as most internal and Italian students as most external; (5) the U.S.S.R. and U.S.A. are perceived differently on content subscales of the I-E Scale although their overall attributed scores do not differ.     

Semantic mechanisms in paralexia

This study explores the effects of semantic constraints on the occurrence of paralexic responses in two patients who tend to produce semantic errors in reading aloud. In the first experiment, semantic constraints were provided by using words as proper names (e.g., “brown” vs. “Sam Brown”), and in the second by using short, highly familiar phrases to restrict the meaning of the target word (e.g., the polar bear; green with envy). These constraints were found to be effective in reducing the frequency of paralexic errors.     

Prejudice Toward Immigrants1

In the present study, 4 variables (realistic threats, symbolic threats, intergroup anxiety, and negative stereotypes) were used to predict prejudice toward immigrants from Cuba, Mexico, and Asia in samples of students from states in the United States that are affected by immigration from these areas (Florida, New Mexico, and Hawaii, respectively). All 4 variables were significant (or marginally significant) predictors of attitudes toward these immigrant groups. Evidence is presented that the predictor variables are conceptually and empirically distinct. However, these variables do appear to be tied together by an underlying theme: They all concern threats to the in-group or its members. Some of the implications of the results for intergroup relations are discussed.     

OSP parameters and the cognitive component of reaction time to a missing stimulus: Linking brain and behavior

This within-subjects experiment tested the relationship between the premotor (cognitive) component of reaction time (RT) to a missing stimulus and parameters of the omitted stimulus potential (OSP) brain wave. Healthy young men (N = 28) completed trials with an auditory stimulus that recurred at 2 s intervals and ceased unpredictably. Premotor RT and Motor RT were measured on active trials that required an immediate response to a missing stimulus. Passive trials required no response in order to measure the complete set of OSP parameters (i.e., onset, rate of rise, amplitude and peak latency). The results showed that faster Premotor RT was strongly associated with a faster rate of rise in the OSP wave. Motor RT was unrelated the OSP parameters. This new evidence is consistent with the occurrence of some common cognitive processes generating behavioral and brain reactions to a missing stimulus.