Perception of sweetness and bitterness in different vehicles

In the present study, we investigated taste-taste, taste-vehicle, and simultaneous taste-vehicle-taste mixtures. Subjects made estimates of the sweetness and bitterness of 27 stimuli. Sucrose (292, 585, and 1170 mM), caffeine (13, 26, and 52 mM), and binary mixtures of low (292-13 mM), middle (585-26 mM), and high (1170-52 mM) levels of both components were dispersed in water, carboxymethylcellulose (CMC) 1% w/v, and gelatin 6% w/v. The sweetness and bitterness of the sucrose-vehicle-caffeine combinations were significantly weaker than the respective sucrose-vehicle and caffeine-vehicle combinations. The emerged mutual suppressive effects were asymmetrical and persisted when both tastants were presented in CMC and gelatin. Moreover, the increase in vehicle consistency and the simultaneous addition of another taste reduced the perceived intensity of a taste either presented alone or dissolved in water. For both sweetness and bitterness, the total taste suppression observed was always significant.     

Phonological transformations in Spanish-speaking aphasics

Thirty-seven aphasic patients whose native language is Spanish were divided into four groups: (1) Broca's, (2) Wernicke's, (3) Conduction, and (4) Anomia. Phonological errors produced on repetition and object-naming tasks were analyzed in terms of type of transformation and degree of similarity between target and errors in terms of shared distinctive features. Segmental transformations were of the following types: (1) pure substitution, (2) pure addition, (3) deletion, (4) reduplicative addition (doublet creation)—anticipatory (right to left) or perseverative (left to right), (5) reduplicative substitution (doublet creation)—anticipatory or perseverative, and (6) mutual exchanges. Pure substitutions were the most prevalent, exchanges, the least. Some error types were found to differentiate significantly between aphasic populations. We suggest that different mechanisms may underlie the same error type for different aphasic populations.     

Major depression can be prevented

The 2009 Institute of Medicine report on prevention of mental, emotional, and behavioral disorders (National Research Council & Institute of Medicine, 2009b) presented evidence that major depression can be prevented. In this article, we highlight the implications of the report for public policy and research. Randomized controlled trials have shown that the incidence of major depressive episodes can be significantly reduced. Meta-analyses suggest that 22% to 38% of major depressive episodes could be prevented with currently available methods. We argue that if major depressive episodes can be prevented, the health care system should provide routine access to evidence-based depression prevention interventions, just as it provides inoculations for other common and debilitating health problems. At the same time, researchers should pursue the major directions advocated by the Institute of Medicine report to increase the enduring effectiveness of future prevention interventions. These directions include taking a developmental perspective, learning to identify groups at high risk, and testing evidence-based interventions that are likely to have the widest reach. Scientific evidence has shown that clinical depression can be averted. Our societies must take action to reduce clinical depression to the lowest possible level. This article is one of three in a special section (see also Biglan, Flay, Embry, & Sandler, 2012; Yoshikawa, Aber, & Beardslee, 2012) representing an elaboration on a theme for prevention science developed by the 2009 report of the National Research Council and Institute of Medicine.     

Procesos de aprendizaje y terapia de conducta en la adicción a la heroína

Resumen

Múltiples principios de condicionamiento clásico y operante interaccionan en la adición a la heroína. Destacan la presencia de RC Compensatorias en forma de Síndrome de Abstinencia Condicionado (SAC) y distintos programas de reforzamiento en el estilo de vida, argot y efectos de la heroína. En evaluación conductual se estudian los correlatos subjetivos y psicofisiológicos del SAC; la validez externa de los autorregistros se logra mediante análisis de orina. En terapia de conducta los programas de amplio espectro se combinan con la intervención comunitaria y apoyo médico. A nivel metodológico se resalta la necesidad de usar múltiples criterios de medición, introducción del análisis multivariado y uso de diseños estadísticos, realización de seguimientos a largo plazo.     

Spanish version of the Prospective and Retrospective Memory Questionnaire (PRMQ-S)

The concept of prospective memory is relatively recent. Thus, it is necessary to have instruments to assess it, in interaction with retrospective memory. The Prospective and Retrospective Memory Questionnaire (PRMQ; Smith et al., 2000) is an instrument that has been effectively used for assessment in several languages. Nevertheless, there is still no Spanish adaptation. The aim of this study was to translate the PRMQ and obtain information about its psychometric properties. A back translation process was applied to the PRMQ. The resulting PRMQ-S was self-administered to 520 subjects after applying the pilot test. Confirmatory factor analysis (CFA) was used to test competing models of its latent structure. Internal consistency was evaluated using Cronbach's alpha. The results showed an adequate internal consistency of the total scale and the Prospective and Retrospective scales were: .89, .84 and .76, respectively. The factor structure was compared with the original study. Our results suggested a disagreement with the tripartite model defended by the authors of the PRMQ. Since there is a high correlation between two factors in the bi-factor model, and the tripartite model showed non-significant loadings to the two specific factors, we recommend that the PRMQ-S be used as one general memory score. We demonstrated adequate psychometric properties of the PRMQ-S if it is used as unique measurement of memory failures. These results are relevant due to the need for a short and accurate instrument in our language that explores memory failures, which has a major impact on the activities of daily living.     

Neuropsychological Interventions for Decision-Making in Addiction: a Systematic Review

Neuropsychology Review - Decision-making deficits are strong predictors of poor clinical outcomes in addiction treatment. However, research on interventions that address decision-making deficits...     

ADHD Correlates, Comorbidity, and Impairment in Community and Treated Samples of Children and Adolescents

Patterns of correlates, comorbidity and impairment associated with attention-deficit hyperactivity disorder (ADHD) in children and youth were examined in representative samples from the community and from treatment facilities serving medically indigent youth in Puerto Rico. Information from caretakers and youths was obtained using the Diagnostic Interview Schedule for Children, (version IV), measures of global impairment, and a battery of potential correlates. In the community (N = 1,896) and the treated samples (N = 763), 7.5 and 26.2% of the children, respectively, met criteria for DSM-IV ADHD in the previous year. Although the prevalence rates and degree of impairment differed, the general patterns of correlates, comorbidity and impairment were similar in both populations. The exceptions were associated with conduct disorder, anxiety, impairment in the ADHD comorbid group, and age factors that appeared to be related to selection into treatment.     

Depression and cocaine dependence

Presence of depression in cocaine-dependent users is relevant for treatment of these persons. This study assessed the presence of depressive symptomatology with a published Spanish translation of the Beck Depression Inventory for a sample of 115 Spanish cocaine-dependent users who were in outpatient treatment at Centers of Drug Dependence of Galicia, Spain. The mean score was 13.7 (SD = 10.3), with 24.3% of the sample having scores which indicate clinical depression (cut off > or =21). These data underscore the need to assess the presence of depression in cocaine-dependent users who require treatment.     

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

Adenosine receptors in the central nervous system have been implicated in the modulation of different behavioural patterns and cognitive functions although the specific role of A(2A) receptor (A(2A)R) subtype in learning and memory is still unclear. In the present work we establish a novel transgenic rat strain, TGR(NSEhA2A), overexpressing adenosine A(2A)Rs mainly in the cerebral cortex, the hippocampal formation, and the cerebellum. Thereafter, we explore the relevance of this A(2A)Rs overexpression for learning and memory function. Animals were behaviourally assessed in several learning and memory tasks (6-arms radial tunnel maze, T-maze, object recognition, and several Morris water maze paradigms) and other tests for spontaneous motor activity (open field, hexagonal tunnel maze) and anxiety (plus maze) as modification of these behaviours may interfere with the assessment of cognitive function. Neither motor performance and emotional/anxious-like behaviours were altered by overexpression of A(2A)Rs. TGR(NSEhA2A) showed normal hippocampal-dependent learning of spatial reference memory. However, they presented working memory deficits as detected by performance of constant errors in the blind arms of the 6 arm radial tunnel maze, reduced recognition of a novel object and a lack of learning improvement over four trials on the same day which was not observed over consecutive days in a repeated acquisition paradigm in the Morris water maze. Given the interdependence between adenosinic and dopaminergic function, the present results render the novel TGR(NSEhA2A) as a putative animal model for the working memory deficits and cognitive disruptions related to overstimulation of cortical A(2A)Rs or to dopaminergic prefrontal dysfunction as seen in schizophrenic or Parkinson's disease patients.