Our world is more than physics: a constructive – critical comment on the current science and theology debate

“Critical realism” is one of the most important positions in the current science and theology debate. An analysis of its origin and meaning leads to the question if this position mostly propagated by physicist-theologians could miss an intrinsic feature of the personal dimension of reality. A deeper meaning of the personal dimension sets human science apart. Taking into account social science's insight that persons responsible for their conclusions and actions drive the process of science, the moral dimension of science has to be emphasized. To integrate these aspects into a coherent position, a more differentiated epistemological model is needed. The solution proposed in this paper is to modify critical realism to constructive-critical realism. Theologically interpreted, constructive-critical realism remembers humankind's purpose to shape nature in cooperation with God and with the means of culture toward increasing realization of freedom in relationship. The argument is widely influenced by an analysis of the works of John Polkinghorne.     

Alternative-based thresholding with application to presurgical fMRI

Functional magnetic reasonance imaging (fMRI) plays an important role in pre-surgical planning for patients with resectable brain lesions such as tumors. With appropriately designed tasks, the results of fMRI studies can guide resection, thereby preserving vital brain tissue. The mass univariate approach to fMRI data analysis consists of performing a statistical test in each voxel, which is used to classify voxels as either active or inactive—that is, related, or not, to the task of interest. In cognitive neuroscience, the focus is on controlling the rate of false positives while accounting for the severe multiple testing problem of searching the brain for activations. However, stringent control of false positives is accompanied by a risk of false negatives, which can be detrimental, particularly in clinical settings where false negatives may lead to surgical resection of vital brain tissue. Consequently, for clinical applications, we argue for a testing procedure with a stronger focus on preventing false negatives. We present a thresholding procedure that incorporates information on false positives and false negatives. We combine two measures of significance for each voxel: a classical p-value, which reflects evidence against the null hypothesis of no activation, and an alternative p-value, which reflects evidence against activation of a prespecified size. This results in a layered statistical map for the brain. One layer marks voxels exhibiting strong evidence against the traditional null hypothesis, while a second layer marks voxels where activation cannot be confidently excluded. The third layer marks voxels where the presence of activation can be rejected.     

Medication for Complex Posttraumatic Disorders

Treatment guidelines and reviews of outcome studies agree that drugs are valuable for moderation of irrational moods and impulsivity that interfere with thoughtfulness and cooperativeness. As such, they empower patients to make good use of psychotherapy for mastery of the risk of betrayal in intimate relationships, which is the typical recurrent traumatic event in complex posttraumatic disorders. Psychotherapy, for its part, has demonstrated correction and lasting remission of disorder in the aftermath of certain kinds of single trauma and promises further development to achieve similar efficacy for complex posttraumatic disorders. This article summarizes the strengths and limitations of each class of psychiatric drugs. It explains how the natural course of complex posttraumatic disorders greatly contaminates observations of medication efficacy and fosters unrealistic expectations for drug development.     

Altruism in adolescents and young adults: validation of an instrument to measure generative altruism with structural equation modeling

Aim of this study was to develop and test a research instrument to measure generative and functional altruism in adolescents/young adults. In an anonymous questionnaire survey using standardised questionnaires, 873 students were recruited in academic high schools and professional schools. The 7-item Generative Altruism Scale (GALS), which includes affective and behavioural elements, correlated with relevant external measures that correspond with the underlying construct. Confirmatory factor analysis proved an acceptable model fit with characteristics of χ² [df = 14, N = 846] = 129.946, p < .001, CFI = .91, AIC = 157.946, and SRMR = .048. Female and male students differed significantly with respect to altruism scores (F = 25.5; p < .0001). The GALS could be used for empirical studies analysing the connection between altruism and the development of ethical values and prosocial behaviour. Particularly, compassion as an intrinsic motivator could be fostered in appropriate education programmes.     

Temporal buffering and visual capacity: The time course of object formation underlies capacity limits in visual cognition

Capacity limits are a hallmark of visual cognition. The upper boundary of our ability to individuate and remember objects is well known but—despite its central role in visual information processing—not well understood. Here, we investigated the role of temporal limits in the perceptual processes of forming “object files.” Specifically, we examined the two fundamental mechanisms of object file formation—individuation and identification—by selectively interfering with visual processing by using forward and backward masking with variable stimulus onset asynchronies. While target detection was almost unaffected by these two types of masking, they showed distinct effects on the two different stages of object formation. Forward “integration” masking selectively impaired object individuation, whereas backward “interruption” masking only affected identification and the consolidation of information into visual working memory. We therefore conclude that the inherent temporal dynamics of visual information processing are an essential component in creating the capacity limits in object individuation and visual working memory.     

Cognitive functions of gamma-band activity: memory match and utilization

Oscillatory neural activity in the gamma frequency range (>30Hz) has been shown to accompany a wide variety of cognitive processes. So far, there has been limited success in assigning a unitary basic function to these oscillations, and critics have raised the argument that they could just be an epiphenomenon of neural processing. We propose a new framework that relates gamma oscillations observed in human, as well as in animal, experiments to two underlying processes: the comparison of memory contents with stimulus-related information and the utilization of signals derived from this comparison. This model attempts to explain early gamma-band responses in terms of the match between bottom-up and top-down information. Furthermore, it assumes that late gamma-band activity reflects the readout and utilization of the information resulting from this match.     

Life-Review Technique in the Treatment of PTSD in Elderly Patients: Rationale and Three Single Case Studies

Persons exposed to traumatic events in childhood and adolescence may suffer from the symptoms of posttraumatic stress disorder (PTSD) well into old age. The aim of this paper is to introduce a structured life-review technique for the treatment of elderly PTSD patients. This technique centers on the discussion and evaluation of each consecutive stage of life. The therapist encourages the patient to reminisce on both positive and negative experiences; positive coping experiences are reinforced. A single session on the traumatic event is integrated into the discussion of the stages of life, which are dealt with in chronological order. In the following, 3 case studies (e.g., survivors of the 1945 Dresden bombing) are presented. Psychometric measures (PTSS-10, IES-R) for the case studies are reported. Finally, the potential and limitations of the pilot study and the new approach are discussed.     

Mind, Self, and Personality: Dynamic Interactions from Late Childhood to Early Adulthood

This paper aims to integrate research on mind, personality, and self-development using a general model which hypothesizes that mind and personality are organized in 3 levels. The first level includes environment-oriented, domain-specific systems that specialize in the representation of and interaction with particular types of relationships in the environment in both the cognitive and the social realms. The second level comprises self-oriented monitoring and representation processes that build maps of the environment-oriented systems. Self and identity derive from the interaction between these 2 levels, which is subject to the constraints and the system's processing capacity at the successive ages. These constraints may be taken as the third level of the self. Efficiency in overcoming these constraints is determined by the self-oriented processes, generating feelings and self-representations of self-worth. These feelings are idiosyncratic, and function as a personal constant, which is applied on self-evaluation and self-representations. This constant is rescaled and differentiated with development. Thus, we have simultaneously both modular and transmodular constructs in the mind and the self, which change with relative independence of each other under the constraints of the general processing capabilities and the personal constant. A series of studies are presented to support this model, and its implications for life-span theories of development are discussed.