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51.
Henri-Corto Stoeklé Marie-France Mamzer-Bruneel Charles-Henry Frouart Christophe Le Tourneau Pierre Laurent-Puig Guillaume Vogt Christian Hervé 《Science and engineering ethics》2018,24(1):307-322
The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine” (DM) (big data, data mining). The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision of care. Molecular tumor boards (MTB) are one response to these changes and are now providing better access to next-generation sequencing (NGS) and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent (IC) documents at all academic medical centers and to introduce dynamic and electronic informed consent (e-IC). 相似文献
52.
Claire Mauger Céline Lancelot Arnaud Roy Régis Coutant Nicole Cantisano Didier Le Gall 《Neuropsychology review》2018,28(2):188-215
Turner syndrome (TS) is a genetic disorder, affecting 1/2500 to 1/3000 live female births, induced by partial or total deletion of one X chromosome. The neurocognitive profile of girls with TS is characterized by a normal Verbal IQ and weaknesses in visual-spatial, mathematics, and social cognitive domains. Executive functions (EFs) impairments have also been reported in these young patients. However, methodological differences across studies do not allow determination of which EFs are impaired and what is the magnitude of these impairments. The aim of this review was to clarify the EF profile of children and adolescents with TS. Sixteen samples, from thirteen studies, were included in the current meta-analysis. EFs measures used in these studies were classified into working memory, inhibitory control, cognitive flexibility, or higher-order EFs tasks in accordance with Diamond’s model, Annual Review of Psychology, 64, 135–168 (2013). Results confirmed that girls with TS had significant executive impairments with effect sizes varying from small (inhibitory control) to medium (cognitive flexibility) and large (working memory, higher-order EFs). Analyses by task revealed that cognitive inhibition may be more impaired than the other inhibitory control abilities. Heterogeneity across cognitive flexibility measures was also highlighted. Between-sample heterogeneity was observed for three tasks and the impact of participants’ characteristics on EFs was discussed. This meta-analysis confirms the necessity to assess, in patients living with TS, each EF by combining both visual and verbal tasks. Results also underline that, when studying girls with TS’ executive profile, it is important to explore the impact of moderator variables, such as IQ, parental socio-economic status, TS karyotype, psychiatric comorbidities, and hormonal treatment status. 相似文献
53.
Fanny Levy Yann Le Strat Nicolas Hoertel Claire Ancelet Caroline Dubertret 《Journal of child and family studies》2018,27(7):2245-2253
While the devastating effects of parental alcohol use on children’s health are well known, the specific impact of childbirth on parental alcohol consumption has rarely been examined in the general population. We sought to examine patterns of alcohol use associated with childbirth. Data were drawn from the US National Epidemiologic Survey on Alcohol and Related Conditions. We compared successively the characteristics of alcohol use among females living with a child under 1 year with (i) those of females not living with children under 1 year and (ii) those of females living with an older child. Mean daily ethanol intake was lower among females living with a child under 1 than among females either not living with children under 1 year (p?<?0.001) or living with an older child (p?<?0.01). Moreover, low-to-mild drinking frequencies fell among females living with a child under 1, compared with females either not living with children under 1 year (adjusted odds ratio (AOR)?=?0.56; 95% CI [0.40, 0.80] for at least once a month and AOR?=?0.40; 95% CI [0.27, 0.58] for less than once a month) or living with an older child (AOR?=?0.52; 95% CI [0.36, 0.75] for at least once a month and AOR?=?0.66, 95% CI [0.46, 0.94] for less than a month). No significant difference was found for males. Our study suggests that childbirth, as opposed to motherhood per se, reduces several (though not all) dimensions of alcohol consumption in females, but not in males. 相似文献
54.
Abraham Olivier 《South African Journal of Philosophy》2018,37(4):452-465
The aim of this paper is to give a critical discussion of Sartre’s concept of sexual desire and its relation to self-identity and freedom. Why Sartre? Sartre is one of very few philosophers who offers a systematic account of sexual desire. He has influenced eminent philosophical concepts of sexual desire held by, for instance, de Beauvoir, Lacan, Foucault, Levinas, Irigaray and Butler, but not much is written about his own notion of sexual desire. This alone is reason to explore Sartre’s view. What makes his view of sexual desire particularly interesting is that it is framed by his theory of freedom. Sartre offers the original, radical notion that freedom is absolute. Because consciousness is never self-identical, he argues, human identity is not fixed. Instead, we are consequently nothing else but what we keep desiring to make of ourselves. He concludes that we are always free to choose our drives and desires, even what seem to be our most enslaving, natural sexual instincts. The question raised in this article, however, concerns what the nature of sexual desire is and how free we really are to choose our sexual desires. I first contextualise Sartre’s view of sexual desire within his notion of desire in general and its relation to instinct, drive, consciousness, freedom and identity. Then, I give a detailed discussion of his analysis of sexual desire, its relation to freedom, and, what Sartre calls its failures. Finally, I discuss a critique of, and alternative to, Sartre’s theory of sexual desire from the perspective of my own notion of heteronomous and autonomous desire and freedom. 相似文献
55.
Chu Kim-Prieto Grace S. Kim Leilani Salvo Crane Susana Ming Lowe Phi Loan Le Khanh T. Dinh 《Women & Therapy》2018,41(3-4):203-218
ABSTRACTAlthough Asian Americans are diverse in many ways, such as language, culture, ethnicity, religion, generational status, and more, many share a common experience: that of having experienced war first hand or being progeny of war survivors. World War II, the Korean War, the Vietnam War, the Cambodian genocide, along with centuries of oppressive and authoritarian rule, have brought experiences of trauma, directly and historically, to the lives of many Asians. Subsequent experiences of migration and resettlement, as well as life in the United States as an ethnic minority, have also compounded the layers of oppression for many Asian Americans. Sexism in our cultures of origin, as well as sexism in the U.S., represents additional realities and traumas faced by Asian American women. In this article, we explore the experiences of war and subsequent traumas in the lives of Asian American women. We present a brief review of the current state of mental health as it relates to the experiences of war trauma, with the goal of providing a crucial contextual backdrop for our review of the best practices in mental health services to Asian American women. We review some of the best practices and conclude with a narrative reflection based on our own involvement in a small professional women’s group that yielded insights, discoveries, healing, and empowerment from the legacy of war trauma. 相似文献
56.
Y. Le Corff E. Yergeau C. Proulx-Bourque M. Busque-Carrier A. Roy-Charland A. Levesque J. Tivendell K. Forget 《Psychologie Fran?aise》2018,63(3):269-275
The aim of the present study was to evaluate the equivalence of the French-Canadian version of the Adult Self-Report (ASR; Achenbach & Rescorla, 2003) to its original English (USA) version. Both the original English version and the newly translated French-Canadian version were administered to 251 bilingual students from four Canadian provinces (Manitoba, New-Brunswick, Ontario, and Quebec), with a one to two weeks interval. Correlations varying from 0.72 to 0.87 indicated a high degree of correspondence between the scales of the two versions. Cohen's d calculated using Morris and DeShon's (2002) formula for within-subjects designs indicate that differences between mean scores varied from near-zero (d = 0.01) to small (d = 0.19), and suggest that they are not clinically significant. Ordinal alpha coefficients for the scales of the French-Canadian version varied from 0.66 to 0.96 but are inferior to those of the English version in seven of the eleven scales. Globally, results indicate that the equivalence of the French-Canadian version to the original English version of the ASR is sufficient to recommend its use. 相似文献
57.
58.
Reducing uncertainty to promote appropriate decisions when facing hazardous phenomena at an active volcano 下载免费PDF全文
Gaëtan Merlhiot Martial Mermillod Jean‐Luc Le Pennec Silvana Hidalgo Laurie Mondillon 《Journal of applied social psychology》2018,48(4):227-234
This study investigated a new direction for improving the decision making of populations at risk in the context of uncertain environmental events, such as volcanic hazards. According to the risk as feelings theory and dual process models, situations with certain outcomes do not necessarily require the use of affect heuristics (e.g., experienced feelings, anticipated emotions) as valid information in the decision‐making process. In the case of difficult decisions with moral dilemmas, certainty could even improve decisions. Thus, using an ecological design with various scenarios depicting upcoming volcanic hazards, we examined whether reducing the uncertainty of lethal threat by conveying certainty in an information campaign could influence decision making and promote a better quality of choice (correct application of the recommendations from the competent authorities). We focused specifically on two populations composed of local people living in the vicinity of an active volcano (Tungurahua volcano, Ecuador) and local scientists. We also examined whether a difficult decision involving a moral dilemma (e.g., leaving people behind so as not to jeopardize one's own life) potentiated this effect, compared to a less difficult situation without a dilemma. We demonstrated that, for local people facing a moral dilemma (difficult decision), the reduction of uncertainty of lethal threat involved a better application of the actual recommendations. These outcomes provided perspectives on improving the applications of the recommendations among local populations at risk in the context of a real risk exposure. 相似文献
59.
Marion Botella Guillaume Fürst Nils Myszkowski Martin Storme Maria Pereira Da Costa Olivier Luminet 《Journal of personality assessment》2015,97(2):209-220
Overexcitability corresponds to an overall response to stimulations in 5 domains: psychomotor, sensual, intellectual, imaginational, and emotional. The aim of this study was to develop a French version of the Overexcitability Questionnaire 2 (OEQ2) and to expand its psychometric properties. Two studies were conducted: one with a sample of 474 adolescents and another with a sample of 436 adults. Internal consistency, factorial structure, and validity (correlations with intelligence, personality, and alexithymia) were examined. The French OEQ2 showed satisfactory psychometric properties, thus advocating for its use in further research on overexcitability and in clinical practice. 相似文献
60.