Complex and subtle structural changes in prefrontal cortex induced by inhibitory control training from childhood to adolescence

A number of training interventions have been designed to improve executive functions and inhibitory control (IC) across the lifespan. Surprisingly, no study has investigated the structural neuroplasticity induced by IC training from childhood to late adolescence, a developmental period characterized by IC efficiency improvement and protracted maturation of prefrontal cortex (PFC) subregions involved in IC. The aim of the present study was to investigate the behavioral and structural changes induced by a 5‐week computerized and adaptive IC training in school‐aged children (10‐year‐olds) and in adolescents (16‐year‐olds). Sixty‐four children and 59 adolescents were randomly assigned to an IC (i.e. Color‐Word Stroop and Stop‐Signal tasks) or an active control (AC) (knowledge‐ and vocabulary‐based tasks) training group. In the pre‐ and posttraining sessions, participants performed the Color‐Word Stroop and Stop‐signal tasks, and an anatomical resonance imaging (MRI) was acquired for each of them. Children's IC efficiency improved from the pre‐ to the posttraining session in boys but not in girls. In adolescents, IC efficiency did not improve after IC training. Similar to the neuroplastic mechanisms observed during brain maturation, we observed IC training‐related changes in cortical thickness and cortical surface area in several PFC subregions (e.g. the pars opercularis, triangularis, and orbitalis of the inferior frontal gyri) that were age‐ and gender‐specific. Because no correction for multiple comparisons was applied, the results of our study provide only preliminary evidence of the complex structural neuroplastic mechanisms at the root of behavioral changes in IC efficiency from pre‐ to posttraining in school‐aged children and adolescents.     

When views about alternative medicine,nature and god come in the way of people's vaccination intentions

In spite of the safety and efficiency of the COVID-19 vaccines and the many promotion efforts of political and expert authorities, a fair portion of the population remained hesitant if not opposed to vaccination. Public debate and the available literature point to the possible role of people's attitudes towards medical institutions as well as their preference for complementary and alternative medicine (CAM) on their motivations and intentions to be vaccinated. Other potential ideological factors are beliefs about environmental laissez-faire and divine providence insofar as they encourage people to let the pandemic unfold without human interference. In three cross-sectional samples (total N = 8214), collected at successive moments during the Belgian vaccination campaign, the present research examines the distal role of these psychological and ideological factors on vaccination intentions via motivational processes. Study 1 gauges the relation between trust in medical institutions and preference for CAM on intentions to get vaccinated via motivations. Study 2 examined the role of beliefs in the desirability of letting nature take its course (‘environmental laissez-faire beliefs’) on vaccination intention via motivations. Study 3 tests whether people's adherence to environmental laissez-faire and beliefs about divine providence are linked to their motivations for vaccination via trust in the medical institutions and CAM. Results show that adherence to CAM has a deleterious effect on vaccination intentions, whereas trust in medical institutions has a positive effect. Both ideological factors pertaining to external control are only moderately related, with environmental laissez-faire beliefs having stronger effects on CAM, medical trust and vaccination motivations. We discuss the importance of this set of results in light of the growing interest in CAM and the increasing presence of messages appealing to the environment.     

Responding to allegations of scientific misconduct

Institutions in France are not yet well prepared to respond to allegations of scientific misconduct. Following a serious allegation in late 1997. INSERM,* the primary organization for medical and health-related research in France, began to reflect on this subject, aided by scientists and jurists. The conclusions have resulted in establishing a procedure to be followed in cases of alleged misconduct, and also in reinforcing the application of good laboratory practices within each laboratory. Guidelines for authorship practices and scientific assessment must also be considered. Even though each institution must remain responsible for responding to allegations of scientific misconduct within its doors, INSERM would like to see national, European, and international co-ordination about the methods of such response. Institut National de la Santé et de la Recherche Médicale (eng. French National Medical Research Institute) is known as INSERM. An earlier version of this paper was presented at a symposium, Scientific Misconduct: An International Perspective, organised by The Medical University of Warsaw, 16 November, 1998.     

Development of the Basel Version of the Awareness of Social Inference Test – Theory of Mind (BASIT-ToM) in healthy adults

Impairments of Theory of Mind (ToM) abilities occur in a wide range of brain disorders. Therefore, reliable and ecologically valid examination of these abilities is a crucial part of any comprehensive neuropsychological assessment. An established and ecologically valid, English-language test identifying deficits in ToM abilities is “The Awareness of Social Inference Test – Social Inference Minimal (TASIT-SIM)”. However, no comparable German-language ToM test currently exists. In this study, we aimed to develop the first German-language adaption of TASIT-SIM in healthy adults. We selected 13 scenes [four scenes per message type (i.e., honesty, simple sarcasm, paradoxical sarcasm) and one practice scene] out of the 30 TASIT-SIM scenes. In collaboration with a film institute, we filmed each scene at three different intensities. These intensity version scenes were then administered to 240 healthy adults, equally distributed in sex and age, ranging from 35 to 92 years. By applying Rasch analysis, we selected intensity versions that showed neither floor nor ceiling effects in the majority of ToM questions in participants whose ToM abilities were in the medium range. In conclusion, we have developed the first German-language adaption of TASIT-SIM, i.e., the “Basel Version of the Awareness of Social Inference Test – Theory of Mind (BASIT-ToM)”. The BASIT-ToM incorporates the strengths of TASIT-SIM, while overcoming its limitations such as inconsistencies in cinematic realization and ceiling effects in healthy participants. Next, the BASIT-ToM needs to be validated in healthy people and clinical populations.     

Food‐related risk‐reduction strategies: purchasing and consumption processes

Confronted with an alarming social discourse favouring the perception of food risk, modern consumers find themselves in a situation of psychological discomfort caused by consumption of foodstuffs coming from the agricultural and foodstuff industry. To eliminate this discomfort the consumer may change their purchasing and consumption habits (constraining hypothesis) or introduce some measures for the reduction of risk. The aim of this paper is to present a new classification of risk reducers taking into account the diversity of buying and consumption practices. Copyright © 2004 Henry Stewart Publications.     

A threat in the elder: the impact of task‐instructions,self‐efficacy and performance expectations on memory performance in the elderly

Widely used explicit memory tasks seem to overestimate age‐related differences in memory performance. Social and personal factors may buffer or undermine the effect of age on memory performance. In two studies, the performance of older adults was compared with the performance of younger adults. Tasks were presented either as memory tasks or non‐memory tasks. Older adults' performance on a memory task improved when the task‐instructions did not explicitly emphasize the memory component of the task. In the first study, results revealed that memory self‐efficacy beliefs play a moderator role on the impact of task‐instruction on memory performance, so that lower levels of memory self‐efficacy correlate with lower performance in the memory emphasizing task condition but not in the orientation emphasizing task condition. In a second study actual performance expectations were measured. For older participants only, expectations were sensitive to task‐instructions and mediated the relation between tasks‐instructions and performances. These findings suggest that observed age‐related differences in memory performance may be significantly exaggerated by the testing situation and by a low memory self‐efficacy and low memory performance expectancies prevalent among older adults. Copyright © 2005 John Wiley & Sons, Ltd.     

Pupil Diameter May Reflect Motor Control and Learning

Non–luminance-mediated changes in pupil diameter have been used since the first studies by Darwin in 1872 as indicators of clinical, cognitive, and arousal states. However, the relation between processes involved in motor control and changes in pupil diameter remains largely unknown. Twenty participants attempted to compensate random walks of a cursor with a computer mouse to restrain its trajectory within a target circle while the authors recorded their pupil diameters. Two conditions allowed the authors to experimentally manipulate the motor and cognitive components of the task. First, the step size of the cursor's random walk was either large or small leading to 2 task difficulties (difficult or easy). Second, they instructed participants to imagine controlling the cursor by moving the mouse, but without actually moving it (task modality: imagined movement or real movement condition). Task difficulty and modality allowed the authors to show that pupil diameters reflect processes involved in motor control and in the processing of feedback, respectively. Furthermore, the authors also demonstrate that motor learning can be quantified by pupil size. This noninvasive approach provides a promising method for investigating not only motor control, but also motor imagery, a research field of growing importance in sports and rehabilitation.     

Actuality and possibility: On the complementarity of two registers in the bodily constitution of experience

The purpose of this paper is to demonstrate the usefulness of the concept of possibility, and not merely that of actuality, for an inquiry into the bodily constitution of experience. The paper will study how the possibilities of action that may (or may not) be available to the subject help to shape the meaning attributed to perceived objects and to the situation occupied by the subject within her environment. This view will be supported by reference to empirical evidence provided by recent and current research on the perceptual estimation of distances and the effects brought about by the use of a tool on the organisation of our perceived immediate space.

Holistic processing is tuned for in-group faces

Past research has found that mere in-group/out-group categorizations are sufficient to elicit biases in face memory. The current research yields novel evidence that mere social categorization is also sufficient to modulate processes underlying face perception, even for faces for which we have strong perceptual expertise: same-race (SR) faces. Using the composite face paradigm, we find that SR faces categorized as in-group members (i.e., fellow university students) are processed more holistically than are SR faces categorized as out-group members (i.e., students at another university). Hence, holding perceptual expertise with faces constant, categorizing an SR target as an out-group member debilitates the strong holistic processing typically observed for SR faces.