Plasma BDNF is reduced among middle-aged and elderly women with impaired insulin function: Evidence of a compensatory mechanism

Brain-derived neurotrophic factor (BDNF) plays a regulatory role in neuronal differentiation and synaptic plasticity and has been linked to glucose regulation and cognition. Associations among plasma BDNF, cognition, and insulin function were explored. Forty-one participants with impaired insulin function (IIF), ranging from insulin resistance to type 2 diabetes mellitus (T2DM), were matched with 41 healthy controls on gender, age, education, and IQ. Participants received complete medical, neurological, psychiatric, and neuropsychological evaluations. IIF individuals had significantly lower plasma BDNF levels than controls, particularly females, and higher BDNF levels were associated with poorer explicit memory in IIF females, suggesting that higher levels within this group may reflect the body’s efforts to respond to damage. After accounting for age, education, and HbA1c, BDNF significantly predicted 13.1–23.5% of the variance in explicit memory in IIF women. These findings suggest that BDNF elevations within diseased groups may not always be a marker of health.     

Parental autonomy support and ethnic culture identification among second-generation immigrants

Born and raised in the United States, children of immigrants often face conflict over whether to endorse the norms and traditions of the family's country of origin (the natal culture) or those of mainstream U.S. society (the host culture). The authors hypothesized that when immigrant parents allow children to make their own choices concerning their cultural identity, their children will be more likely to internalize the natal culture and will experience greater well-being. Ninety-nine college-aged 2nd-generation immigrants rated their well-being, perceptions of their mother's and father's autonomy support, and their endorsement of both natal and U.S. cultures. Results demonstrated that paternal, but not maternal, autonomy support predicted greater well-being and greater endorsement of the natal culture and that immersion in the natal culture predicted some indices of well-being. Several explanations for the possibly greater significance of paternal versus maternal autonomy support in the context of immigrant families are considered.     

Is hypnotic suggestibility a stable trait?

The present study examined the trait-like nature of hypnotic suggestibility by examining the stability of hypnotic responsiveness in a test-retest design in which the procedures were administered either live or by audiotape. Contrary to the idea that hypnotizability is a largely immutable, stable trait, scores on the scale of hypnotic responsiveness decreased significantly at the second session. Measures of subjective experiences and expectancies accounted for a sizable portion of the variance in hypnotic responding, both at initial test and at retest. Participants became disengaged with the hypnotic procedures at retest. Participants who received the hypnotic induction by audiotape did not differ from participants who received it live. The results are consistent with sociocognitive and altered state theories of hypnosis, and underline the important role of subjective experiences in hypnotic responding.     

Functional analysis skills training for residential caregivers

Functional analysis is the most effective assessment for identifying the maintaining contingencies of aberrant behavior. However, it is suggested that functional analyses are not conducted regularly due to the level of skill required. A multiple baseline design across participants was used to assess if four residential caregivers, with limited experience with applied behavior analysis, could be trained to implement the standard analog functional analysis conditions. The training consisted of a lecture, written information, modeling, rehearsal, and feedback. Results showed that all participants attained percentage correct responding scores above 95% on three consecutive trials following training. One caregiver showed positive generalization of skills to the assessment of another behavioral topography. The result of this study provides further evidence that lay individuals can be trained to assist in conducting functional analyses. Copyright © 2008 John Wiley & Sons, Ltd.     

Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory

Evidence suggests that plasticity of the amygdalar and hippocampal GABAergic system is critical for fear memory formation. In this study we investigated in wild-type and genetically manipulated mice the role of the activity-dependent 65-kDa isozyme of glutamic acid decarboxylase (GAD65) in the consolidation and generalization of conditioned fear. First, we demonstrate a transient reduction of GAD65 gene expression in the dorsal hippocampus (6 h post training) and in the basolateral complex of the amygdala (24 h post training) during distinct phases of fear memory consolidation. Second, we show that targeted ablation of the GAD65 gene in Gad65(-/-) mice results in a pronounced context-independent, intramodal generalization of auditory fear memory during long-term (24 h or 14 d) but not short-term (30 min) memory retrieval. The temporal specificity of both gene regulation and memory deficits in Gad65 mutant mice suggests that GAD65-mediated GABA synthesis is critical for the consolidation of stimulus-specific fear memory. This function appears to involve a modulation of neural activity patterns in the amygdalo-hippocampal pathway as indicated by a reduction in theta frequency synchronization between the amygdala and hippocampus of Gad65(-/-) mice during the expression of generalized fear memory.     

Developmental trajectories for spatial frames of reference in Williams syndrome

Williams syndrome (WS) is a genetic disorder associated with severe visuocognitive impairment. Individuals with WS also report difficulties with everyday wayfinding. To study the development of body-, environment-, and object-based spatial frames of reference in WS, we tested 45 children and adults with WS on a search task in which the participant and a spatial array are moved with respect to each other. Although individuals with WS showed a marked delay, like young controls they demonstrated independent, additive use of body- and environment-based frames of reference. Crucially, object-based (intrinsic) representations based on local landmarks within the array were only marginally used even by adults with WS, whereas in typical development these emerge at 5 years. Deficits in landmark use are consistent with wayfinding difficulties in WS, and may also contribute to problems with basic localization, since in typical development landmark-based representations supplement those based on the body and on self-motion. Difficulties with inhibition or mental rotation may be further components in the impaired ability to use the correct reference frame in WS.     

Religion,Politics and Ethics: Towards a Global Theory of Social Transformation

In this paper I set out a phenomenology of social transformation, based on an analysis of the distinctively religious form of communication which underlies the trans-generational and trans-cultural transmission of world traditions, taking Confucianism and Christianity as their representatives. A phenomenological analysis of their communicative structure allows the possibility of a better understanding of what can be learnt from them in the context of contemporary debates in both China and the West on the relations between religion, ethics and politics. This analysis suggests that the ethical consistency of belief and act, which is the necessary condition for the engendering of long-term solidarity in religious community, has significant implications for ethics in politics, and especially for the legitimacy of representational leadership as a focal point for change in society. The paper concludes that the historical experience of world religions can offer new insights into the nature of political leadership and representation in today’s globalised world and that the appropriate locus for this inquiry is the present negotiation and re-negotiation of relations between China and the West.     

Comparison of classical and modern methods for measuring and correcting for acquiescence

Likert-type self-report scales are frequently used in large-scale educational assessment of social-emotional skills. Self-report scales rely on the assumption that their items elicit information only about the trait they are supposed to measure. However, different response biases may threaten this assumption. Specifically, in children, the response style of acquiescence is an important source of systematic error. Balanced scales, including an equal number of positively and negatively keyed items, have been proposed as a solution to control for acquiescence, but the reasons why this design feature worked from the perspective of modern psychometric models have been underexplored. Three methods for controlling for acquiescence are compared: classical method by partialling out the mean; an item response theory method to measure differential person functioning (DPF); and multidimensional item response theory (MIRT) with random intercept. Comparative analyses are conducted on simulated ratings and on self-ratings provided by 40,649 students (aged 11–18) on a fully balanced 30-item scale assessing conscientious self-management. Acquiescence bias was explained as DPF and it was demonstrated that: the acquiescence index is highly related to DPF; balanced scales produce scores controlled for DPF; and MIRT factor scores are highly related to scores controlled for DPF and the random intercept is highly related to DPF.     

Darwinizing debunking arguments

To ‘Darwinize’ a debunking argument is to broaden and thereby strengthen it in ways inspired by Charles Darwin. It is to employ Darwinian strategies that converge on the conclusion that certain putative phenomena – the reality of stance‐independent moral properties, for instance – are illusory or epistemically problematic for animals like us. The aim of this essay is to defend one such strategy and illustrate its power relative to most evolutionary debunking arguments currently on offer.