Plasma BDNF is reduced among middle-aged and elderly women with impaired insulin function: Evidence of a compensatory mechanism

Brain-derived neurotrophic factor (BDNF) plays a regulatory role in neuronal differentiation and synaptic plasticity and has been linked to glucose regulation and cognition. Associations among plasma BDNF, cognition, and insulin function were explored. Forty-one participants with impaired insulin function (IIF), ranging from insulin resistance to type 2 diabetes mellitus (T2DM), were matched with 41 healthy controls on gender, age, education, and IQ. Participants received complete medical, neurological, psychiatric, and neuropsychological evaluations. IIF individuals had significantly lower plasma BDNF levels than controls, particularly females, and higher BDNF levels were associated with poorer explicit memory in IIF females, suggesting that higher levels within this group may reflect the body’s efforts to respond to damage. After accounting for age, education, and HbA1c, BDNF significantly predicted 13.1–23.5% of the variance in explicit memory in IIF women. These findings suggest that BDNF elevations within diseased groups may not always be a marker of health.     

Distance estimation in vista space

Although distance estimation has been extensively studied in the laboratory, our ability to judge large distances in the field is not well researched. We challenge the notion that large distances are uniformly underestimated. We presented different targets to observers at distances ranging from 25 to 500 m to obtain egocentric distance judgments in natural environments. Three experiments showed that observers tend to underestimate distances below 75 m in a large open field, whereas they overestimate farther distances. Both the eye height of the observer and the size of the target also influenced distance estimation. We conclude that the notion of a uniform vista space has to be reconceived.     

Social Anxiety and Anger Identification: Bubbles Reveal Differential Use of Facial Information With Low Spatial Frequencies

ABSTRACT— We investigated the facial information that socially anxious and nonanxious individuals utilize to judge emotions. Using a reversed-correlation technique, we presented participants with face images that were masked with random bubble patterns. These patterns determined which parts of the face were visible in specific spatial-frequency bands. This masking allowed us to establish which locations and spatial frequencies were helping participants to successfully discriminate angry faces from neutral ones. Although socially anxious individuals performed as well as nonanxious individuals on the emotion-discrimination task, they did not utilize the same facial information for the task. The fine details (high spatial frequencies) around the eyes were discriminative for both groups, but only socially anxious participants additionally processed rough configural information (low spatial frequencies).     

Asymmetrical cortical processing of radial expansion / contraction in infants and adults

We report asymmetrical cortical responses (steady‐state visual evoked potentials) to radial expansion and contraction in human infants and adults. Forty‐four infants (22 3‐month‐olds and 22 4‐month‐olds) and nine adults viewed dynamic dot patterns which cyclically (2.1 Hz) alternate between radial expansion (or contraction) and random directional motion. The first harmonic (F1) response in the steady‐state VEP response must arise from mechanisms sensitive to the global radial motion structure. We compared F1 amplitudes between expansion‐random and contraction‐random motion alternations. F1 amplitudes for contraction were significantly larger than those for expansion for the older infants and adults but not for the younger infants. These results suggest that the human cortical motion mechanisms have asymmetrical sensitivity for radial expansion vs. contraction, which develops at around 4 months of age. The relation between development of sensitivity to radial motion and cortical motion mechanisms is discussed.     

Bodies against the law: Abu Ghraib and the war on terror

In this essay, I argue that the contemporary notion of law has been reduced to regulations and disciplinary codes that do not and cannot give meaning to our emotional lives and moral sensibilities. As a result, we have increasing numbers of what I call “abysmal individuals” who suffer from a split between law—broadly conceived as that which gives form and structure to social life—and personal embodied sensations of pain and pleasure. My attempt to understand the place of Abu Ghraib within American culture leads to an analysis of our valorization of innocence and ignorance that not only becomes the grounds on which we morally (if not legally) excuse abusive behavior as “fun,” but also becomes part of the justification for condoning some forms of violence while condemning others. In addition, I argue that the distinction between legitimate and illegitimate violence trades on underlying assumptions about the relationship between culture and nature, technology and bodies, wherein bodies are imagined as natural and outside of the realm of law.

Nonmonotonic abductive inductive learning

Inductive Logic Programming (ILP) is concerned with the task of generalising sets of positive and negative examples with respect to background knowledge expressed as logic programs. Negation as Failure (NAF) is a key feature of logic programming which provides a means for nonmonotonic commonsense reasoning under incomplete information. But, so far, most ILP research has been aimed at Horn programs which exclude NAF, and has failed to exploit the full potential of normal programs that allow NAF. By contrast, Abductive Logic Programming (ALP), a related task concerned with explaining observations with respect to a prior theory, has been well studied and applied in the context of normal logic programs. This paper shows how ALP can be used to provide a semantics and proof procedure for nonmonotonic ILP that utilises practical methods of language and search bias to reduce the search space. This is done by lifting an existing method called Hybrid Abductive Inductive Learning (HAIL) from Horn clauses to normal logic programs. To demonstrate its potential benefits, the resulting system, called XHAIL, is applied to a process modelling case study involving a nonmonotonic temporal Event Calculus (EC).     

Writing and reading skills as assessed by teachers in 7-year olds: A behavioral genetic approach

A behavioral genetic analysis of general writing ability was conducted using teacher assessments based on UK National Curriculum criteria for a sample of 3296 same-sex pairs of 7-year-old twins. Writing was highly heritable within the normal range (0.66) and at the low extreme (0.70). Environmental influences were almost all non-shared, with shared environmental estimates negligible (0.07 normal range, 0.06 low extreme). Bivariate genetic analyses of teacher assessments of writing and reading indicated that 69% of the genetic influences on writing were in common with those on reading, and that the two skills shared all of their shared environmental influences. In contrast, non-shared environmental factors are largely specific, with 86% independent of those on reading.     

An investigation into the temporal dimension of the Mozart effect: evidence from the attentional blink task

In the present study, we examined whether the 'Mozart effect' would influence participants' temporal attention using a visual attentional blink (AB) task that provides a reliable measure of the temporal dynamics of visual attention. The 'Mozart effect' refers to the specific claim that listening to Mozart's Sonata for Two Pianos in D Major, K.448 can improve the performance in spatio-temporal tasks. Participants had to try and identify two target digits (in their correct order of presentation) presented amongst a stream of distractor letters in three different conditions (presented in separate blocks of trials): while listening to the Mozart sonata played normally, while listening to the same Mozart sonata played in reverse, and while in silence. The results showed that the participants were able to detect the second target (T2) significantly more accurately (given the correct detection of the first target, T1) in the AB stream when the Mozart sonata was played normally than in either of the other two conditions. Possible explanations for the differential effects of Mozart's music being played normally and in reverse and potential confounds in previous studies reporting a facilitatory 'Mozart effect' are discussed. Our results therefore provide the first empirical demonstration supporting the existence of a purely temporal component to the 'Mozart effect' using a non-spatial visual AB task.     

Individual differences in components of reaction time distributions and their relations to working memory and intelligence

The authors bring together approaches from cognitive and individual differences psychology to model characteristics of reaction time distributions beyond measures of central tendency. Ex-Gaussian distributions and a diffusion model approach are used to describe individuals' reaction time data. The authors identified common latent factors for each of the 3 ex-Gaussian parameters and for 3 parameters central to the diffusion model using structural equation modeling for a battery of choice reaction tasks. These factors had differential relations to criterion constructs. Parameters reflecting the tail of the distribution (i.e., tau in the ex-Gaussian and drift rate in the diffusion model) were the strongest unique predictors of working memory, reasoning, and psychometric speed. Theories of controlled attention and binding are discussed as potential theoretical explanations.