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While many studies have attempted to produce hypertension through the use of various environmental Stressors, few have succeeded in producing chronic elevations in blood pressure beyond levels considered to be borderline hypertensive (140–160 mm Hg systolic). The problem with most studies stems from the use of genetically normotensive animals and the selection of Stressors to which animals readily adapt. A new approach is suggested, which recognizes the role of genetics in human essential hypertension. Animals with one hypertensive parent do not develop spontaneous hypertension but show a more sensitive cardiovascular response to environmental Stressors than animals with normotensive parents. Preliminary studies revealed that animals with a mixed genetic history of hypertension develop spontaneous borderline hypertension. When subjected to shock-shock conflict, these borderline hypertensive rats (BHR) developed permanent hypertension that failed to abate even after a ten-week, shock-free recovery period. The hypertension was accompanied by elevated heart weight to body weight ratios and by significant cardiac pathology. Subsequent work has demonstrated that these animals also become hypertensive when fed a high-sodium diet. Finally, in a series of exercise studies, we found that BHRs subjected to a shock stressor were protected against stress-induced hypertension if they exercised daily. The potential of this model for studies of the mechanisms by which environmental variables produce permanent hypertension is discussed. 相似文献
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A. James Cox 《Journal of religion and health》1986,25(1):73-85
One of the most necessarily sensitive areas of pastoral care is dealing with perinatal death. This case study grows from a need for care providers to understand better the feelings of a mother in the loss of her baby. This particular exploration evolved from a taped interview with the writer's aunt (now in her seventies) and her dealings with the multiple losses she experienced over fifty years ago. Her conversation in the interview gives credibility to many coping skills that we endeavor to teach today and that she developed for herself out of a need to survive....it was as if the birds would never sing again.-Aunt Grace 相似文献
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Katherine A. Hirchak PhD MHPA Melanie Nadeau PhD MPH Angel Vasquez PhD Alexandra Hernandez-Vallant MS Kyle Smith Cuong Pham MD Karen Anderson Oliver PhD Paulette Baukol BS Karen Lizzy CDP Racquel Shaffer CPC Jalene Herron MS Aimee N. C. Campbell PhD Kamilla L. Venner PhD The CTN- Collaborative Board 《American journal of community psychology》2023,71(1-2):174-183
American Indian/Alaska Native (AI/AN) communities are disproportionally impacted by the opioid overdose epidemic. There remains a dearth of research evaluating methods for effectively implementing treatments for opioid use disorder (OUD) within these communities. We describe proceedings from a 2-day Collaborative Board (CB) meeting tasked with developing an implementation intervention for AI/AN clinical programs to improve the delivery of medications to treat OUD (MOUD). The CB was comprised of Elders, cultural leaders, providers, individuals with lived experience with OUD, and researchers from over 25 communities, organizations, and academic institutions. Conversations were audio-recorded, transcribed, and coded by two academic researchers with interpretation oversight provided by the CB. These proceedings provided a foundation for ongoing CB work and a frame for developing the program-level implementation intervention using a strength-based and holistic model of OUD recovery and wellbeing. Topics of discussion posed to the CB included engagement and recovery strategies, integration of extended family traditions, and addressing stigma and building trust with providers and clients. Integration of traditional healing practices, ceremonies, and other cultural practices was recommended. The importance of centering AI/AN culture and involving family were highlighted as priorities for the intervention. 相似文献
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Shayna Skakoon-Sparling Paolo A. Palma Adhm Zahran Trevor A. Hart David M. Moore Joseph Cox Nathan J. Lachowsky Milada Dvorakova Emerich Daroya Daniel Grace 《Social and Personality Psychology Compass》2023,17(9):e12814
In March 2020, in response to the COVID-19 pandemic, Canadian provincial governments instituted a variety of public health measures that included social distancing and isolation, which may have had unintended consequeses. According to the Loneliness and Sexual Risk Model, gay, bisexual, and other men who have sex with men (GBM) often cope with loneliness through risky sexual behaviors. Previous studies have demonstrated that COVID-19 measures such as social distancing and isolation led to increases in loneliness; thus, these measures may also have led to elevated sexual risk-taking among some GBM. Participants were recruited from an ongoing cohort study on GBM health and well-being, and were included in the current analysis if they had completed relevant study questions (n = 1134). GBM who reported lower levels of social support pre-COVID-19, were younger, and lived alone each reported greater loneliness during the first year of COVID-19. Although feelings of loneliness did not predict sexual risk-taking within the first year of COVID-19, loneliness did predict greater sexual risk-taking 6 months later. Additionally, younger GBM and those living alone were more likely to engage in sexual risk-taking at both COVID-19 data collection points. These findings offer some support of the Loneliness and Sexual Risk Model; however, it is possible that the unique circumstances of the COVID-19 pandemic resulted in a temporary suspension of this association, as many GBM took steps to protect themselves and partners in the context of COVID-19. 相似文献
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Reexamination of the role of the hypothalamus in motivation 总被引:3,自引:0,他引:3
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