The Portuguese version of Addenbrooke’s Cognitive Examination–Revised (ACE-R) in the diagnosis of subcortical vascular dementia and Alzheimer’s disease

The aim of this study was to investigate the accuracy of the Portuguese version of Addenbrooke’s Cognitive Examination–Revised (ACE-R) in detecting and differentiating early stage subcortical vascular dementia (SVD) from early stage Alzheimer’s disease (AD). Ninety-two subjects (18 SVD patients, 36 AD patients, and 38 healthy controls) were assessed using the ACE-R. Between-group’s differences were evaluated using the Quade’s rank analysis of covariance. The diagnostic accuracy and discriminatory ability of the ACE-R were examined via receiver operating characteristic (ROC) analysis. The ACE-R was able to successfully discriminate between patients and healthy subjects. The mean ACE-R total scores differed between SVD and AD patients; there were also significant differences in attention and orientation and in memory measures between the groups. An optimal cut-off of 72/73 was found for the detection of AD (sensitivity: 97%; specificity: 92%) and SVD (sensitivity: 100%; specificity: 92%).     

Intracerebroventricular effects of angiotensin II on a step-through passive avoidance task in rats

A wealth of evidence indicates that angiotensin II (Ang II) is involved in learning and memory. However, the precise role of this peptide in these cognitive processes is still controversial, with data indicating either an inhibitory or an enhancing action. The present study was designed to further investigate the effects of intracerebroventricular injections of Ang II (0.5, 1 or 3nmol/5microl) on a step-through passive avoidance task in male adult Wistar rats. When administered pretraining, Ang II did not affect the acquisition of passive avoidance, but markedly improved avoidance performance when given before the retrieval test. The latter effect was observed in retest sessions performed up to 72h after training. Administration of the peptide five minutes after training impaired retention of inhibitory avoidance. Therefore, Ang II may exert opposite effects on passive avoidance memory according to its interference with brain mechanisms leading to the storage or retrieval of this aversively motivated task.     

Sustainable Technologies and Transdisciplinary Futures: From Collaborative Design to Digital Fabrication

This paper argues for hands-on, contextual and problem-solving collaborations, that is, for a transdisciplinary approach that establishes direct connections between social and technical disciplines. It is based on our experience as a team of researchers at the Vitruvius Fab Lab (Digital Fabrication Laboratory) of ISCTE-IUL (University Institute of Lisbon, Portugal). The paper presents a particular research and learning initiative–STTF2013 Summer School ‘Sustainable Technologies and Transdisciplinary Futures: From Collaborative Design to Digital Fabrication’, which served as a testbed for our transdisciplinary, critical and open approach. We address its rationale and main challenges, while also discussing recommendations for other transdisciplinary projects striving to integrate social and technical disciplines in research and innovation.     

Dominance and competence face to face: Dissociations obtained with a reverse correlation approach

The article explores whether the traits representing the dimensions underlying the structure of facial and non-facial impressions are similarly mapped in the face space. Two studies examine whether the trustworthiness-by-dominance and the warmth-by-competence two-dimensional models overlap in face perception. In Study 1 (N = 200), we used a reverse-correlation task to obtain classification images (CIs) reflecting how each dimension is mapped onto a face. Results show that the similarity between CIs was higher between warmth and trustworthiness than between competence and dominance. In Study 2 (N = 31) the evaluations of each CI on each social dimension show a higher dissociation between dominance and competence than between trustworthiness and warmth. These results, obtained at both perceptual and judgment levels, suggest that there is only a partial correspondence between the two models that seems to be driven by the relationship that the competence and dominance dimensions establish with valence.     

Autobiographical Narratives of Oldest-Old Persons: What Matters at That Age?

This study adopts the Valuation theory and the Self-Confrontation Method to explore the autobiographic narrative in oldest old persons, considering a temporal perspective (past, present, future). The sample comprises three men and two women (84-95 years old). The findings suggest that the narrative of oldest-old persons emerges structured in a way that their narration of the past focus on outside connections (proximity with others; success achieved); their narration of the present centers on attaining a life philosophy and proximity with others and their narration of the future concentrates on self-enhancement (maintaining autonomy vs. experiencing powerlessness and lack of involvement).     

Age-related changes in multi-finger interactions in adults during maximum voluntary finger force production tasks

This study aimed to continue our characterization of finger strength and multi-finger interactions across the lifespan to include those in their 60s and older. Building on our previous study of children, we examined young and elderly adults during isometric finger flexion and extension tasks. Sixteen young and 16 elderly, gender-matched participants produced maximum force using either a single finger or all four fingers in flexion and extension. The maximum voluntary finger force (MVF), the percentage contributions of individual finger forces to the sum of individual finger forces during four-finger MVF task (force sharing), and the non-task finger forces during a task finger MVF task (force enslaving), were computed as dependent variables. Force enslaving during finger extension was greater than during flexion in both young and elderly groups. The flexion-extension difference was greater in the elderly than the young adult group. The greater independency in flexion may result from more frequent use of finger flexion in everyday manipulation tasks. The non-task fingers closer to a task finger produced greater enslaving force than non-task fingers farther from the task finger. The force sharing pattern was not different between age groups. Our findings suggest that finger strength decreases over the aging process, finger independency for flexion increases throughout development, and force sharing pattern remains constant across the lifespan.     

Temporomandibular Disorder in Brazilian Patients: A Preliminary Study

The objective of the current study was to evaluate disease-related beliefs, adherence to treatment, quality of life, coping strategies and cognitive status in a group of Brazilian patients with Temporomandibular Disorder (TMD). Thirty patients were evaluated with a semi-directed interview, the Coping Strategies Inventory, and a Mini-Mental State Examination. Although half (50%) of the patients had known their diagnosis long term, 40% of the sample were not correctly following proposed treatment. All patients had a similar pattern of pain behavior related to TMD, while disease-related beliefs, quality of life and coping strategies were variable. Expectations about treatment also had significant association with treatment adherence. The findings of this study suggest that a more thorough understanding of individual differences in TMD is warranted.     

The Quality of Home Environment in Brazil: An Ecological Model

Based on Bronfenbrenner's (1999) ecological perspective, a longitudinal, prospective model of individual differences in the quality of home environment (Home Observation for Measurement of the Environment—HOME) was tested in a sample of 179 Brazilian children and their families. Perinatal measures of family socioeconomic status (SES) and child birth weight had direct effects on HOME at preschool age. As either family SES or child birth weight increased, HOME also increased through diminished emotional distress in the mother a month following childbirth. SES had a negative effect on number of children in the household, which in turn had a long-term negative impact on HOME. Compared to mothers who had reported not to plan their pregnancy, those who did were more likely to have fewer children, to report more spouse support during childbearing, and to show less emotional distress a month after childbirth, all of which also influenced HOME at preschool age. These findings are discussed in light of the broader socio-ecological Brazilian context, with direct implications to clinical practice aimed at improving the quality of home environment.