Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms

A promising target for memory improvement is phosphodiesterase type 5 (PDE5), which selectively hydrolyzes cyclic guanosine monophosphate (cGMP). In rodents, PDE5 inhibitors (PDE5-Is) have been shown to improve memory performance in many behavioral paradigms. However, it is questioned whether the positive effects in animal studies result from PDE5 inhibition in the central nervous system or the periphery. Therefore, we studied the effects of PDE5 inhibition on memory and determined whether compound penetration of the blood-brain barrier (BBB) is required for this activity. Two selective PDE5-Is, vardenafil and UK-343,664, were tested in the object recognition task (ORT) in both a MK-801- and scopolamine-induced memory deficit model, and a time-delay model without pharmacological intervention. Compounds were dosed 30 min before the learning trial of the task. To determine if the PDE5-Is crossed the BBB, their concentrations were determined in plasma and brain tissue collected 30 min after oral administration. Vardenafil improved object recognition memory in all three variants of the ORT. UK-343,664 was ineffective at either preventing MK-801-induced memory disruption or time-dependent memory decay. However, UK-343,664 attenuated the memory impairment of scopolamine. Vardenafil crossed the BBB whereas UK-343,664 did not. Further, co-administration of UK-343,664 and scopolamine did not alter the brain partitioning of either molecule. This suggests that the positive effect of UK-343,664 on scopolamine-induced memory decay might arise from peripheral PDE5 inhibition. The results herein suggest that there may be multiple mechanisms that mediate the efficacy of PDE5 inhibition to improve memory performance in tasks such as the ORT and that these involve PDE5 located both within and outside of the brain. To further elucidate the underlying mechanisms, the cellular and subcellular localization of PDE5 needs to be determined.     

The Effects of a Summer Camp Program in China on Children's Knowledge,Attitudes, and Behaviors Toward Animals: A Model for Conservation Education

ABSTRACT

This summative evaluation, conducted in Chengdu, Sichuan Province, China, studied whether participation in a conservation education camp positively changed 8–12-year-old children's (a) knowledge of how to protect animals, (b) care about animals, (c) propensity for environmental and wildlife stewardship, and (d) compassionate behavior toward animals and nature. Influenced by conservation psychology, social learning theory, empathy and moral development, constructivism, and conservation biology, 5-day overnight camps were conducted at 2 zoological institutions. Activities were designed to help children form bonds with animals and care enough to positively change their behavior toward animals and nature. Mixed methods, using pre- and postvisit surveys, researcher field notes, vignettes, student journals, an end of camp questionnaire, and a camper behavior ethogram, revealed significant increases in knowledge, care, and propensity for action, and an additional theme, empathy. This study identified effective strategies to promote positive behavior toward animals, empathy, and conservation behavior.     

Motivational Interviewing Promotes Adherence and Improves Wellbeing in Pre-Dialysis Patients with Advanced Chronic Kidney Disease

Low rates of adherence to medical treatments and adverse emotional states are a widespread problem in advanced chronic kidney disease (ACKD). Motivational interviewing using the stages of change model is an effective combination in promoting behavior modifications. The objective of the present study was to determine the effectiveness of an individual, pre-dialysis intervention program (monthly sessions of 90 min over a 6-month period) in terms of adherence, emotional state and health-related quality of life (HRQL). Forty-two patients were evaluated for adherence, depression, anxiety and HRQL with standardized self-report questionnaires. Biochemical markers were also registered. The results show that after the intervention, patients reported significantly higher levels of adherence, lower depression and anxiety levels, and better HRQL (i.e., general health and emotional role domains). Biochemical parameters were controlled significantly better after the intervention, except for iPTH. These findings highlight the potential benefit of applying individual psycho-educational intervention programs based on motivational interviewing and using the stages of change model to promote adherence and wellbeing in ACKD patients.     

Ethnic Prejudice,Resilience, and Perception of Inclusion of Immigrant Pupils among Italian and Catalan Teachers

Journal of Child and Family Studies - In the current study we investigated the relationship between ethnic prejudice and resilience and the perception of inclusion of immigrant students among...     

The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Systematic Review and Meta-analysis

Neuropsychology Review - Mindfulness-based programs (MBPs) are increasingly utilized to improve mental health. Interest in the putative effects of MBPs on cognitive function is also growing. This...     

Ergebnisqualität von psychotherapeutischen Prozessen mit Jugendlichen

Background

This study investigated the effectiveness of therapeutic processes with adolescents depending on (1) the quality of the therapeutic relationship, (2) generic change indicators and (3) the appearance of specific forms of communication in the initial phase of therapeutic processes. The study concentrated on investigation of the first three initial therapy sessions and was interested in the possible association of these three variables with positive outcomes and in the young patients remaining in therapy.

Material and methods

A total of 20 therapeutic processes, which took place in Santiago de Chile, were examined. Participants were 15 female and 5 male adolescents between 13 and 17 years old and suffering from different psychological disorders. The Chilean version of Horvath’s working alliance inventory, Generic Change Indicators, the Therapeutic Activity Coding System (TACS), Lambert’s outcome questionnaire OQ-45.2 and adherence in terms of completing or not completing therapy were used to assess process and outcome variables.

Results

The three variables measured in the initial phase of therapy with adolescents, i.e. therapeutic alliance, generic change indicators and communicative actions showed a relationship with the therapeutic results in terms of adherence to therapy as well as outcome.

Discussion

The results indicate the necessity of a greater inclusion of the perspective of adolescents in the therapeutic process.

     

Digital disruption? Maternal mobile device use is related to infant social‐emotional functioning

Mobile device use has become increasingly prevalent, yet its impact on infant development remains largely unknown. When parents use mobile devices in front of infants, the parent is physically present but most likely distracted and unresponsive. Research using the classic Still Face Paradigm (SFP) suggests that parental withdrawal and unresponsiveness may have negative consequences for children's social‐emotional development. In the present study, 50 infants aged 7.20 to 23.60 months (M = 15.40, SD = 4.74) and their mothers completed a modified SFP. The SFP consisted of three phases: free play (FP; parent and infant play and interact), still face (SF; parent withdraws attention and becomes unresponsive), and reunion (RU; parent resumes normal interaction). The modified SFP incorporated mobile device use in the SF phase. Parents reported on their typical mobile device use and infant temperament. Consistent with the standard SFP, infants showed more negative affect and less positive affect during SF versus FP. Infants also showed more toy engagement and more engagement with mother during FP versus SF and RU. Infants showed the most social bids during SF and more room exploration in SF than RU. More frequent reported mobile device use was associated with less room exploration and positive affect during SF, and less recovery (i.e., engagement with mother, room exploration positive affect) during RU, even when controlling for individual differences in temperament. Findings suggest that the SFP represents a promising theoretical framework for understanding the impact of parent's mobile device use on infant social‐emotional functioning and parent–infant interactions.     

Mixed matters: fluency impacts trust ratings when faces range on valence but not on motivational implications

Facial features that resemble emotional expressions influence key social evaluations, including trust. Here, we present four experiments testing how the impact of such expressive features is qualified by their processing difficulty. We show that faces with mixed expressive features are relatively devalued, and faces with pure expressive features are relatively valued. This is especially true when participants first engage in a categorisation task that makes processing of mixed expressions difficult and pure expressions easy. Critically, we also demonstrate that the impact of categorisation fluency depends on the specific nature of the expressive features. When faces vary on valence (i.e. sad to happy), trust judgments increase with their positivity, but also depend on fluency. When faces vary on social motivation (i.e. angry to sad), trust judgments increase with their approachability, but remain impervious to disfluency. This suggests that people intelligently use fluency to make judgments on valence-relevant judgment dimensions – but not when faces can be judged using other relevant criteria, such as motivation. Overall, the findings highlight that key social impressions (like trust) are flexibly constructed from inputs related to stimulus features and processing experience.     

Democratisation of wellbeing: stakeholder perspectives on policy priorities for improving national wellbeing through paid employment and adult learning

Recent policy initiatives in the UK have heightened the degree to which wellbeing can be considered a political construct: The acceptance of different policy options for wellbeing depends on the extent to which those options are responsive to popular wellbeing concerns. Drawing on the views of over 400 people gathered through a variety of methods and across the UK, we outline different stakeholder views of what wellbeing is and the priorities that stakeholders believe should be addressed to improve wellbeing. We draw out the implications for reframing policy debates around wellbeing, the practice of career guidance, academic debates around identified wellbeing priorities, and the best means of developing a policy and a practice-oriented and stakeholder-responsive approach to researching wellbeing.