LQTS Parents’ Reflections About Genetic Risk Knowledge and their Need to Know or Not to Know their Children’s Carrier Status

Long QT syndrome (LQTS) is a contributor to unexplained deaths in infants (SIDS), children, teenagers and young adults. A gene test result may allow for individual tailored treatment, but also pose a burden of knowing one’s carrier status, with no treatment recommendation. Genetic risk knowledge in the case of LQTS can promote adjustment and coping, but also fear anxiety, ambivalence and moral dilemmas. This makes it challenging to respect both the right to know and the right not to know. The purpose of this study was to explore LQTS parents’ perception of genetic knowledge, and their need to know or not to know about their children’s carrier status. Qualitative, semi structured interviews were conducted with thirteen parents of LQTS-children. Results show that parents found it important to know the result of a gene test for LQTS including their children’s carrier status. The risk was framed and incorporated into their everyday life and their life perspectives. Pertinent moral dilemmas concerned information disclosure to children and relatives. Parents thought that early and gradual disclosure to children would promote coping. Parents’ moral dilemmas were rarely addressed during encounters with healthcare providers. The participants had several suggestions for improvement in that regard.     

Body ownership affects visual perception of object size by rescaling the visual representation of external space

Size perception is most often explained by a combination of cues derived from the visual system. However, this traditional cue approach neglects the role of the observer’s body beyond mere visual comparison. In a previous study, we used a full-body illusion to show that objects appear larger and farther away when participants experience a small artificial body as their own and that objects appear smaller and closer when they assume ownership of a large artificial body (“Barbie-doll illusion”; van der Hoort, Guterstam, & Ehrsson, PLoS ONE, 6(5), e20195, 2011). The first aim of the present study was to test the hypothesis that this own-body-size effect is distinct from the role of the seen body as a direct familiar-size cue. To this end, we developed a novel setup that allowed for occlusion of the artificial body during the presentation of test objects. Our results demonstrate that the feeling of ownership of an artificial body can alter the perceived sizes of objects without the need for a visible body. Second, we demonstrate that fixation shifts do not contribute to the own-body-size effect. Third, we show that the effect exists in both peri-personal space and distant extra-personal space. Finally, through a meta-analysis, we demonstrate that the own-body-size effect is independent of and adds to the classical visual familiar-size cue effect. Our results suggest that, by changing body size, the entire spatial layout rescales and new objects are now perceived according to this rescaling, without the need to see the body.     

Updating working memory in aircraft noise and speech noise causes different fMRI activations

The present study used fMRI/BOLD neuroimaging to investigate how visual‐verbal working memory is updated when exposed to three different background‐noise conditions: speech noise, aircraft noise and silence. The number‐updating task that was used can distinguish between “substitution processes,” which involve adding new items to the working memory representation and suppressing old items, and “exclusion processes,” which involve rejecting new items and maintaining an intact memory set. The current findings supported the findings of a previous study by showing that substitution activated the dorsolateral prefrontal cortex, the posterior medial frontal cortex and the parietal lobes, whereas exclusion activated the anterior medial frontal cortex. Moreover, the prefrontal cortex was activated more by substitution processes when exposed to background speech than when exposed to aircraft noise. These results indicate that (a) the prefrontal cortex plays a special role when task‐irrelevant materials should be denied access to working memory and (b) that, when compensating for different types of noise, either different cognitive mechanisms are involved or those cognitive mechanisms that are involved are involved to different degrees.     

An Examination of the Personality Constructs Underlying Dimensions of Creative Problem‐Solving Style

This study investigated the personality facets that underpin the construct of problem‐solving style, particularly when approaching more creative kinds of problem‐solving. Cattell's Sixteen Personality Factors Questionnaire and VIEW—An Assessment of Problem Solving Style were administered to 165 students from the Norwegian Business School. We explored relationships through correlational and regression analysis. Personality profiles were derived for each of VIEW's three dimensions and were in generally expected directions. Those with an Explorer preference were more imaginative and idea oriented, open to change, unconventional, freethinking, and flexible than Developers. Those with a Developer preference were more practical and solution oriented, more traditional, rule conscious, conservative, and respecting of traditional ideas. Those with an External preference were more group oriented, affiliative, socially bold, warm, and attentive to others than those with an Internal preference. Those with a more Task‐oriented preference were more impersonal, detached, utilitarian, and tough minded than those with Person‐oriented preference. We outlined implications and suggestions for further research.     

Personalized medicine: evidence of normativity in its quantitative definition of health

Systems medicine, which is based on computational modelling of biological systems, is emerging as an increasingly prominent part of the personalized medicine movement. It is often promoted as ‘P4 medicine’ (predictive, preventive, personalized, and participatory). In this article, we test promises made by some of its proponents that systems medicine will be able to develop a scientific, quantitative metric for wellness that will eliminate the purported vagueness, ambiguity, and incompleteness—that is, normativity—of previous health definitions. We do so by examining the most concrete and relevant evidence for such a metric available: a patent that describes a systems medicine method for assessing health and disease. We find that although systems medicine is promoted as heralding an era of transformative scientific objectivity, its definition of health seems at present still normatively based. As such, we argue that it will be open to influence from various stakeholders and that its purported objectivity may conceal important scientific, philosophical, and political issues. We also argue that this is an example of a general trend within biomedicine to create overly hopeful visions and expectations for the future.     

Investigating the Links Between Cultural Values and Belief in Conspiracy Theories: The Key Roles of Collectivism and Masculinity

Research suggests that belief in conspiracy theories (CT) stems from basic psychological mechanisms and is linked to other belief systems (e.g., religious beliefs). While previous research has extensively examined individual and contextual variables associated with CT beliefs, it has not yet investigated the role of culture. In the current research, we tested, based on a situated cultural cognition perspective, the extent to which culture predicts CT beliefs. Using Hofstede's model of cultural values, three nation-level analyses of data from 25, 19, and 18 countries using different measures of CT beliefs (Study 1, N = 5323; Study 2a, N = 12,255; Study 2b, N = 30,994) revealed positive associations between masculinity, collectivism, and CT beliefs. A cross-sectional study among U.S. citizens (Study 3, N = 350), using individual-level measures of Hofstede's values, replicated these findings. A meta-analysis of correlations across studies corroborated the presence of positive links between CT beliefs, collectivism, r = .31, 95% CI = [.15; .47], and masculinity, r = .39, 95% CI = [.18; .59]. Our results suggest that in addition to individual differences and contextual variables, cultural factors also play an important role in shaping CT beliefs.     

The role of philosophy and ethics at the edges of medicine

Background

The purpose of this study is to make a philosophical argument against the phenomenological critique of standardization in clinical ethics. We used the context of clinical ethics in Saudi Arabia to demonstrate the importance of credentialing clinical ethicists.

Methods

Philosophical methods of argumentation and conceptual analysis were used.

Results

We found the phenomenological critique of standardization to be flawed because it relies on a series of false dichotomies.

Conclusions

We concluded that the phenomenological framing of the credentialing debate relies upon two extreme views to be navigated between, not chosen among, in the credentialing of clinical ethicists.