The effect of number of kanji radical companions in character activation with a multi-radical-display task

The majority of Japanese complex kanji consist of two subword units (radicals), and each radical is differentiated according to its combinability. Radical-type frequency is defined as the number of radical companions (NC) functioning as the number of characters containing that radical. The current study is intended to address the question of whether the NC plays a role in kanji character activation under a multi-radical-display (MRD) instead of a tachistoscopic display. An MRD task was used in which the NC was manipulated and the frequency of use of the whole characters was matched on average across the experimental conditions. Participants were divided into two groups (good knowledge vs poor knowledge) according to the score of a kanji completion task. The participants' task was to select an appropriate combination of radicals to compose a legitimate character under the MRD condition. The poor-knowledge group yielded relatively more errors than did the good-knowledge group in the low-NC condition, whereas the good-knowledge group yielded more errors in the high-NC condition than in the low-NC condition. These results demonstrate the different influences of NC as metaknowledge (tacit knowledge of radical productivity) in both good and poor readers.     

Informed consent for the diagnosis of brain death: a conceptual argument

Background

This essay provides an ethical and conceptual argument for the use of informed consent prior to the diagnosis of brain death. It is meant to enable the family to make critical end-of-life decisions, particularly withdrawal of life support system and organ donation, before brain death is diagnosed, as opposed to the current practice of making such decisions after the diagnosis of death. The recent tragic case of a 13-year-old brain-dead patient in California who was maintained on a ventilator for over 2 years illustrates how such a consent would have made a crucial difference.

Methods

Conceptual, philosophical, and ethical analysis.

Results

I first consider a conceptual justification for the use of consent for certain non-beneficial and unwanted medical diagnoses. I suggest that the diagnosis of brain death falls into this category for some patients. Because the diagnostic process of brain death lacks the transparency of traditional death determination, has a unique epistemic structure and a complex risk-benefit profile which differs markedly from case to case, and presents conflicts of interest for physicians and society, I argue that pre-diagnostic counseling and informed consent should be part of the diagnostic process. This approach can be termed as “allow cardiac death”, whose parallel logic with “allow natural death” is discussed. I also discuss potential negative impacts on organ donation and health care cost from this proposal and offer possible mitigation. I show that the pre-diagnostic counseling can improve the possibility for well-thought-out decisions regarding organ donation and terminating life-support system in cases of hopeless prognosis. This approach differs conceptually from the pluralism of the definition of death, such as those in New Jersey and Japan, and it upholds the Uniform Determination of Death Act.

Conclusions

My intention is not to provide an instant panacea for the ongoing impasse of the brain death debate, but to point to a novel conceptual ground for a more pragmatic, and more patient- and family-centered approach. By enabling the family to consent to or decline the diagnostic process of brain death, but not to choose the definition of death, it upholds the current legal definition of death.

     

Relation of type A behavior and multidimensionally measured narcissistic personality of Japanese university students

The revised version of the Type A Behavior Assessment Scale and the Narcissistic Personality Inventory short version were administered to 104 university students. The former scale has three subscales, Impatience and Hostile Speech Style, Achievement Striving and Job Commitment, and Time Urgency. The latter scale has three subscales. Need for Attention and Praise, Sense of Superiority, and Competence and Self-assertion. Analysis gave a total of five significant correlations between the subscales of the two questionnaires; Impatience and Hostile Speech Style of Type A is positively correlated with scores on two subscales of the narcissism measure, Need for Attention and Praise. Self-assertion, and Achievement Striving and Job Commitment of Type A is positively correlated with scores on all three subscales of the narcissism measure.     

Narcissism, variability in self-concept, and well-being

The present research examined whether narcissism is related to higher variability in self-concept across roles and time points. Three indices of self-concept variability across roles were formulated based on the participants’ self-ratings for personality attributes. A probabilistic sample in Study 1 as well as a student sample in Study 2 revealed that the narcissistic personality inventory (NPI) positively correlated with the variability indices, except for the self-concept differentiation (SCD), while well-being measures were only related to SCD. The student sample also showed a significant correlation between NPI and longitudinal variability in self-concept within a month-long interval. Implications for the instability of the narcissistic self-concept and its relationship with psychological well-being are discussed.     

Dynamic modulation of an orientation preference map by GABA responsible for age-related cognitive performance

Accumulating evidence suggests that cognitive declines in old (healthy) animals could arise from depression of intracortical inhibition, for which a decreased ability to produce GABA during senescence might be responsible. By simulating a neural network model of a primary visual cortical (V1) area, we investigated whether and how a lack of GABA affects cognitive performance of the network: detection of the orientation of a visual bar-stimulus. The network was composed of pyramidal (P) cells and GABAergic interneurons such as small (S) and large (L) basket cells. Intrasynaptic GABA-release from presynaptic S or L cells contributed to reducing ongoing-spontaneous (background) neuronal activity in a different manner. Namely, the former exerted feedback (S-to-P) inhibition and reduced the frequency (firing rate) of action potentials evoked in P cells. The latter reduced the number of saliently firing P cells through lateral (L-to-P) inhibition. Non-vesicular GABA-release, presumably from glia and/or neurons, into the extracellular space reduced the both, activating extrasynaptic GABAa receptors and providing P cells with tonic inhibitory currents. By this combinatorial, spatiotemporal inhibitory mechanism, the background activity as noise was significantly reduced, compared to the stimulus-evoked activity as signal, thereby improving signal-to-noise (S/N) ratio. Interestingly, GABA-spillover from the intrasynaptic cleft into the extracellular space was effective for improving orientation selectivity (orientation bias), especially when distractors interfered with detecting the bar-stimulus. These simulation results may provide some insight into how the depression of intracortical inhibition due to a reduction in GABA content in the brain leads to age-related cognitive decline.     

A new type of soil material for a burrowing chamber for mice

We measure general activity of mice(Mus musculus) in a burrowing chamber from an ecological point of view. Natural topsoil or sand, however, is not suitable for long-term dwelling of mice, because burrows are likely to keep collapsing and to become rapidly rotten from being sprinkled with water to guard against collapse. For the present study, we devised a mixture of absorbent cotton and wood shavings as soil material. The mice burrowed in this soil just as they would in natural soil. About 10⁴ cm³ of the cotton-shavings soil were durable for at least 40 days with 3 mice. These results suggest that this soil material can be a useful tool in not only the study of general activity but also other studies (e.g., the observation of maternal behavior of mice in burrows).     

Construction of a conditional probability learning model and information theoretical evaluation of its efficiency

A learning model is introduced based on the simple idea that a learning subject has two hypotheses about the results (the outputs of the environment) caused by his actions and calculates the a posteriori probabilities of the hypotheses. Introducing a randomized decision rule of actions related to the probabilities, it is shown that the model is equivalent to Luce's beta model, while these models are derived from completely different considerations. Introducing an information theoretic measure and martingale theory, the asymptotic behavior of the model is examined. Using the information theoretic measure, the effect of memory function on the learning behavior is evaluated. Finally, the model is extended in such a way that the learning subject has more than two hypotheses or a continuum of hypotheses. The learning behaviors of the extended models are discussed.     

Benefits of negative thinking and negative affect: analyses of answers to an open-ended question by Japanese undergraduates

What are the benefits of negative thinking and negative affect? Although previous studies in evolutionary psychology, social psychology, and clinical psychology have clarified the question, there has been no definitive study asking people directly about the perceived benefits. In the present study, 119 Japanese undergraduates were asked how they recognized the benefits of negative thinking and negative affect. Their answers were analyzed qualitatively. The answers were arranged into 30 smaller categories and 12 superordinate ones. The benefits were divided into "benefits to the self" and "benefits to interpersonal relations". Finally, the conditions necessary for the negative thinking and negative affect being benign, and possible cultural differences, were discussed.     

Retrospective diagnosis of a famous historical figure: ontological,epistemic, and ethical considerations

The aim of this essay is to elaborate philosophical and ethical underpinnings of posthumous diagnosis of famous historical figures based on literary and artistic products, or commonly called retrospective diagnosis. It discusses ontological and epistemic challenges raised in the humanities and social sciences, and attempts to systematically reply to their criticisms from the viewpoint of clinical medicine, philosophy of medicine, particularly the ontology of disease and the epistemology of diagnosis, and medical ethics. The ontological challenge focuses on the doubt about the persistence of a disease over historical time, whereas the epistemic challenge disputes the inaccessibility of scientific verification of a diagnosis in the past. I argue that the critics are in error in conflating the taxonomy of disease (nosology) and the act of diagnosing a patient. Medical diagnosis is fundamentally a hypothesis-construction and an explanatory device that can be generated under various degrees of uncertainty and limited amount of information. It is not an apodictic judgment (true or false) as the critics presuppose, but a probabilistic (Bayesian) judgment with varying degrees of plausibility under uncertainty. In order to avoid this confusion, I propose that retrospective diagnosis of a historical figure be syndromic without identifying underlying disease, unless there is justifiable reason for such specification. Moreover it should be evaluated not only from the viewpoint of medical science but also in a larger context of the scholarship of the humanities and social sciences by its overall plausibility and consistency. On the other hand, I will endorse their concerns regarding the ethics and professionalism of retrospective diagnosis, and call for the need for situating such a diagnosis in an interdisciplinary scope and the context of the scholarship of the historical figure. I will then enumerate several important caveats for interdisciplinary retrospective diagnosis using an example of the retrospective diagnosis of Socrates for his life-long intermittent neurologic symptoms. Finally, I will situate the present argument in a larger context of the major debate among the historians of medicine and paleopathologists, and discuss the similarities and differences.