Acute memory deficits in chemotherapy-treated adults

Data from research on amnesia and epilepsy are equivocal with regards to the dissociation, shown in animal models, between rapid and slow long-term memory consolidation. Cancer treatments have lasting disruptive effects on memory and on brain structures associated with memory, but their acute effects on synaptic consolidation are unknown. We investigated the hypothesis that cancer treatment selectively impairs slow synaptic consolidation. Cancer patients and their matched controls were administered a novel list-learning task modelled on the Rey Auditory Verbal Learning Test. Learning, forgetting, and retrieval were tested before, and one day after patients’ first chemotherapy treatment. Due to difficulties recruiting cancer patients at that sensitive time, we were only able to study 10 patients and their matched controls. Patients exhibited treatment-dependent accelerated forgetting over 24 hours compared to their own pre-treatment performance and to the performance of control participants, in agreement with our hypothesis. The number of intrusions increased after treatment, suggesting retrieval deficits. Future research with larger samples should adapt our methods to distinguish between consolidation and retrieval causes for treatment-dependent accelerated forgetting. The presence of significant accelerated forgetting in our small sample is indicative of a potentially large acute effect of chemotherapy treatment on forgetting, with potentially clinically relevant implications.     

Developmental trajectories and reciprocal associations between career adaptability and vocational identity: A three-wave longitudinal study with adolescents

The purpose of this longitudinal study was two-fold. First, we investigated patterns of stability and change in career adaptability and vocational identity in adolescents. Second, we examined reciprocal associations between career adaptability and vocational identity. In addressing both research aims we tested the moderating effects of gender, school-type, and age. Participants were 1151 (58.7% female) adolescents. They filled in measures that appraised career adapt-abilities and vocational identity processes three times during a school year. Latent growth curve analyses highlighted slight longitudinal decreases in career concern, control, and confidence especially in boys, vocational school students, and middle-to-late adolescents. Also, over time boys and students attending vocational schools reported less in-depth occupational exploration, less identification with present vocational commitments, and more flexibility and self-doubt about their careers. Findings of cross-lagged path analyses highlighted reciprocal associations between career adaptability and vocational identity. Career adaptability positively predicted adolescents' ways of dealing with vocational exploration and commitment. Vocational commitment and reconsideration of commitment predicted career adapt-abilities in time. These results indicate that career adaptability and vocational identity are dynamic and interrelated dimensions of adolescent career development. Implications for theory and practice are discussed.     

Anterior cingulate cortex findings in child disruptive behavior disorders.: A meta-analysis

The brain imaging literature suggests that child disruptive behavior disorders (DBD) are associated with structural and functional abnormalities of the anterior cingulate cortex (ACC).However, there is a lot of heterogeneity in findings in terms of direction of modifications identified until this point. The present study used a meta-analytic design to aggregate the empirical findings from the literature on functional and structural abnormalities of the ACC in children with DBD. A total of eight structural and functional brain imaging (sMRI and fMRI) studies were included and results obtained from a sample of 266 children show a large effect size (D = ?.98 (95% CI [? 1.18, ? 0.77]) in terms of reduced activation of the ACC in children presenting with DBD. Effects of ACC abnormality were moderated by: 1) the type of imaging used in the study (i.e., functional vs. structural); 2) the presence or absence of co-morbid attention deficit hyperactivity disorder (ADHD); 3) the mean age of the samples of children presenting with DBD. Overall, findings confirm functional impairments of the ACC in children with DBD and highlight the importance of using such neurological information to design innovative treatments.