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Indirect evidence has implicated glutamate and gamma-amino butyric acid in memory formation for one-trial passive avoidance learning. We have further examined this by following the time course of glutamate and gamma-amino butyric acid release from slices prepared from the intermediate medial hyperstriatum ventrale of day-old chicks (Ross 1 Chunky) trained to avoid a bead covered in the aversant methylanthranilate. At various times after training, slices of left and right intermediate medial hyperstriatum ventrale were incubated in medium containing 50 mM potassium chloride and amino acid release was determined. Thirty minutes after training there was a bilateral increase in calcium-dependent glutamate release in slices from methylanthranilate-trained chicks compared to those trained to peck water. This increase was sustained until 1 h in the left hyperstriatum when an increase in calcium-dependent gamma-amino butyric acid release was also apparent. Glutamate uptake was also enhanced in left hyperstriatum (30 and 60 min) and in the right at 30 min. In the right intermediate medial hyperstriatum ventrale of methylanthranilate birds glutamate release was increased from 3 to 6.5 h and gamma-amino butyric acid at 6.5 h: a time that corresponded to the mobilization of a late process required if long-term memory was to be formed. These results confirm that the amino acids glutamate and gamma-amino butyric acid are released from the intermediate hyperstriatum ventrale in a calcium-dependent, neurotransmitter-like manner. Furthermore, changes in the release of these two amino acids accompany memory formation for a one-trial learning task in the day-old chick. 相似文献
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Vast amounts of neuropsychological evidence have been collected in recent years in support of the hypothesis that developmental dyslexia is caused not only by phonological deficits, but also by timing deficits that affect all senses (e.g., Tallal, Miller, & Fitch, 1995; Stein & Walsh, 1997). In parallel, recent developments in the study of Hebrew reading place heavy emphasis on root awareness in the mental lexicon and early root extraction in the process of word identification (e.g., Frost, Forster, & Deutch, 1997). The present study creates a link between the timing hypothesis and the special demands of Hebrew reading. The performance of dyslexics and normally reading children is compared on tasks requiring visual extraction of trigrams that approximates extracting roots out of Hebrew words. Partial findings show that dyslexics take longer and make more errors while performing trigram extractions on all levels examined, and that sequentiality in the task affects dyslexics and skilled readers in different ways. 相似文献
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Rémy Versace Élodie Labeye Guillemette Badard Marylène Rose 《Journal of Cognitive Psychology》2013,25(4):522-560
Through a review of the literature, this paper proposes arguments in favour of a multimodal, dynamic, functional, and situational conception of memory. Memory is assumed to contain traces that reflect past experiences. The properties of these experiences are considered to be distributed across multiple neuronal systems, which are responsible, in particular, for sensorimotor and emotional processing. Memory is dynamic because knowledge emerges almost continuously from the activation and integration of these multimodal components. Memory is functional and situational because knowledge emerges from the subject's activity in a given situation, that is from a type of resonance between the properties of the past experiences that have shaped the neuronal networks and the properties of present experiences. 相似文献
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