Intra-amygdala muscimol injections impair freezing and place avoidance in aversive contextual conditioning

Rats were trained by shocking them in a closed compartment. When subsequently tested in the same closed compartment with no shock, normal rats showed an increased tendency to freeze. They also showed an increased tendency to actively avoid the compartment when given access to an adjacent neutral compartment for the first time. Amygdala inactivation with bilateral muscimol injections before training attenuated freezing and eliminated avoidance during the test. Rats trained in a normal state and given intra-amygdala muscimol injections before the test did not freeze or avoid the shock-paired compartment. This pattern of effects suggests that amygdala inactivation during training impaired acquisition of a conditioned response (CR) due either to inactivation of a neural substrate essential for its storage or to elimination of a memory modulation effect that facilitates its storage in some other brain region(s). The elimination of both freezing and active avoidance by amygdala inactivation during testing suggests that neither of these behaviors is the CR. The possibility that the CR is a set of internal responses that produces both freezing and avoidance as well as other behavioral effects is discussed.     

Disruption of latent inhibition to a contextual stimulus with systemic amphetamine

This experiment examined the effects of 0.5 and 1.5 mg/kg doses of amphetamine (AMP) in male Wistar rats, on conditioning to a contextual stimulus that for half the animals has been pre-exposed, in an appetitive conditioning procedure. Amphetamine was administered during both pre-exposure (3 days) and acquisition (15 days). Latent inhibition (LI, reduced conditioning in pre-exposed relative to non-pre-exposed rats) was seen in controls but not at either AMP dose. This abolition of LI was seen under AMP at two levels of responding in acquisition and confirmed in drug free extinction. It suggests that, like conditioning to discrete stimuli, conditioning to contextual stimuli is subject to LI and can be disrupted by AMP.     

Young children who abandon error behaviourally still have to free themselves mentally: a retrospective test for inhibition in intuitive physics

When preschoolers overcome persistent error, subsequent patterns of correct choices may identify how the error had been overcome. Children who no longer misrepresented a ball rolling down a bent tube as though it could only fall vertically, were asked sometimes to approach and sometimes to avoid where the ball landed. All children showed requisite task-switching flexibility. The pattern of 4-year-olds' correct choices among different places showed unnecessary avoidance of any place that would previously have tempted them into a vertical-approach error, 5-year-olds rebounded into a reversal, and 7-year-olds were flexible. The data attest to an inhibition mechanism, ruling out competing possibilities.     

Neuroendocrine responses to psychological stress in eumenorrheic and oligomenorrheic women

Neuroendocrine adaptive responses to psychological stress include activation of the hypothalamic-pituitary-adrenal (HPA) axis and sometimes suppression of the hypothalamic-pituitary-gonadal (HPG) axis. In women who experience chronic stress, these responses are probably responsible for disturbances in the menstrual cycle. In the present experiment, we investigated the effect of an acutely stressful situation on the physiological and neuroendocrine responses in college age women. We hypothesized that females who are experiencing some degree of abnormal menstrual function or women who have less-robust cycles (oligomenorrheic females) would exhibit differences in gonadotropin secretion from eumenorrheic females when exposed to psychological stressors. Fifteen women completed this study: eumenorrheic (n = 5) and oligomenorrheic women (n = 5) who experienced a series of psychological stressors, and eumenorrheic controls (n = 5). Blood samples were taken at 10 min intervals for 8 h (09:00-17:00) in each woman during the mid-follicular phase of the menstrual cycle. The psychological stressors were administered for 1 h beginning at 13:00 h. Luteinizing hormone (LH), growth hormone (GH) and cortisol were measured in each sample to assess the effect of stress on secretion of these hormones. Deconvolution analysis was used to analyze pulsatile hormone secretion and the approximate entropy (ApEn) statistic analyzed the regularity of release of each hormone. Although, there were significant changes in heart rate (HR), skin resistance (SR) and cortisol levels in the stressed women during the psychological stressor compared to resting baseline values but not in the controls, there was no difference in either LH or GH secretion between women who experienced stress and those who did not. Furthermore, there were no differences in the LH or GH secretion patterns in the oligomenorrheic and eumenorrheic women exposed to the psychological stressor.     

Dorsal hippocampus function in learning and expressing a spatial discrimination

Learning to discriminate between spatial locations defined by two adjacent arms of a radial maze in the conditioned cue preference paradigm requires two kinds of information: latent spatial learning when the rats explore the maze with no food available, and learning about food availability in two spatial locations when the rats are then confined in one arm with food and the other with no food. Previous research showed that a functional dorsal hippocampus is not required for latent learning. The present experiments show that it is required for learning about food availability, and during retrieval of both types of information.     

Rapid induction of specific associative behavioral memory by stimulation of the nucleus basalis in the rat

Hypothesized circuitry enabling behavioral memory formation can be tested by its direct activation in the absence of normal experience. Neuromodulation via the cortical release of acetylcholine by the nucleus basalis (NB) is hypothesized to be sufficient to induce specific, associative behavioral memory. Previously, we found that tone paired with stimulation of the nucleus basalis (NBs) for 3000 trials over 15 days induced such memory, supporting the hypothesis. However, as standard associative memory can be established much more rapidly, we asked whether NB-induced memory develops rapidly. Adult male Sprague-Dawley rats, trained and tested in the same calm, waking state, were divided into Paired (n=5) and control (n=4) groups, each of which received a single session of 200 trials of an 8.0 kHz conditioned stimulus (CS) either paired with NBs or with unpaired presentation of NBs. Respiration, cardiac activity, and evoked potentials in the primary auditory cortex (ACx) were recorded. Memory and its degree of specificity were assessed 24 h later by presenting tones of various frequencies (1-15 kHz) in the absence of NBs to yield behavioral frequency generalization gradients. Behavioral responses to test tones consisted of interruption of ongoing respiration and changes in heart rate. Post-training behavioral generalization gradients exhibited response peaks centered on the CS frequency for the Paired group alone. Tone evoked potentials from the ACx also developed CS-specific plasticity. The findings indicate that NB induction of specific behavioral associative memory, like normal memory, can develop rapidly and is accompanied by specific cortical plasticity, supporting the view that NB engagement during normal learning produces memory.     

Beyond mind-reading: multi-voxel pattern analysis of fMRI data

A key challenge for cognitive neuroscience is determining how mental representations map onto patterns of neural activity. Recently, researchers have started to address this question by applying sophisticated pattern-classification algorithms to distributed (multi-voxel) patterns of functional MRI data, with the goal of decoding the information that is represented in the subject's brain at a particular point in time. This multi-voxel pattern analysis (MVPA) approach has led to several impressive feats of mind reading. More importantly, MVPA methods constitute a useful new tool for advancing our understanding of neural information processing. We review how researchers are using MVPA methods to characterize neural coding and information processing in domains ranging from visual perception to memory search.     

The importance of gesture in children's spatial reasoning

On average, men outperform women on mental rotation tasks. Even boys as young as 4 1/2 perform better than girls on simplified spatial transformation tasks. The goal of our study was to explore ways of improving 5-year-olds' performance on a spatial transformation task and to examine the strategies children use to solve this task. We found that boys performed better than girls before training and that both boys and girls improved with training, whether they were given explicit instruction or just practice. Regardless of training condition, the more children gestured about moving the pieces when asked to explain how they solved the spatial transformation task, the better they performed on the task, with boys gesturing about movement significantly more (and performing better) than girls. Gesture thus provides useful information about children's spatial strategies, raising the possibility that gesture training may be particularly effective in improving children's mental rotation skills.     

Sex similarities and differences in preferences for short-term mates: what, whether, and why

Are there sex differences in criteria for sexual relationships? The answer depends on what question a researcher asks. Data suggest that, whereas the sexes differ in whether they will enter short-term sexual relationships, they are more similar in what they prioritize in partners for such relationships. However, additional data and context of other findings and theory suggest different underlying reasons. In Studies 1 and 2, men and women were given varying "mate budgets" to design short-term mates and were asked whether they would actually mate with constructed partners. Study 3 used a mate-screening paradigm. Whereas women have been found to prioritize status in long-term mates, they instead (like men) prioritize physical attractiveness much like an economic necessity in short-term mates. Both sexes also show evidence of favoring well-rounded long- and short-term mates when given the chance. In Studies 4 and 5, participants report reasons for having casual sex and what they find physically attractive. For women, results generally support a good genes account of short-term mating, as per strategic pluralism theory (S. W. Gangestad & J. A. Simpson, 2000). Discussion addresses broader theoretical implications for mate preference, and the link between method and theory in examining social decision processes.     

Practical Reasons and the Redundancy of Motives

Jonathan Dancy, in his 1994 Aristotelian Society Presidential Address, set out to show 'why there is really no such thing as the theory of motivation'. In this paper I want to agree that there is no such thing, and to offer reasons of a different kind for that conclusion. I shall suggest that the so-called theory of motivation misconstrues the question which it purports to answer, and that when we properly analyse the question and distinguish it clearly from other questions with which it should not be confused, we do not need a theory of motivation at all.