Chronic sweet intake lowers pain thresholds without changing brain mu- or delta-opiate receptors

Sprague-Dawley rats drank sweetened (3% dextrose + 0.144% saccharin, w/v) or unflavored water for 18 days and subsequent pain reactivity was assessed using a hot plate. Compared to the rats that consumed unflavored water, the rats that consumed sweet water responded more quickly on the hot plate indicating that their threshold for pain was lowered. Another group of rats given identical exposure to the fluids had their brains prepared for measuring opiate receptor binding using the delta-receptor ligand [3H]D-Ala-D-Leu-enkephalin ([3H]DADLE) and the mu-receptor selective ligand [3H]Tyr-D-Ala-Gly-MePhe-Gly-ol ([ 3H]DAGO). Binding of these opiates to mu- and delta-receptors in the cerebral cortex, striatum, hippocampus, hypothalamus, brain stem, and remaining brain regions was the same for the rats that drank sweet fluids and those that drank unflavored water. These findings suggest that drinking sweet fluids lowers pain thresholds but does not alter mu- and delta-receptors.     

Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats

Recent evidence indicates that acetylcholine and dopamine play complementary roles in cognitive as well as motor functions. In our previous study, the dopamine receptor blocker, haloperidol, was found to attenuate the radial-arm maze choice accuracy deficit caused by the muscarinic acetylcholine receptor blocker, scopolamine. Haloperidol has activity in blocking both D1 and D2 dopamine receptor subtypes. The current study was conducted to determine whether this dopamine-acetylcholine interaction specifically involved D1 or D2 dopamine receptors. The D1 antagonist, SCH 23390, and the D2 antagonist, raclopride, were administered with a dose of scopolamine which caused choice accuracy deficits in the radial-arm maze. The scopolamine-induced deficit was reversed by SCH 23390, the D1 antagonist, indicating that D1 blockade alone is sufficient to reverse the amnestic effects of muscarinic blockade. There was no indication in this study that the D2 blocker, raclopride, had a similar effect. However, this does not mean that such an effect may not be present at other doses of raclopride or with other D2 antagonists. The present finding that D1 blockade counteracts scopolamine-induced cognitive dysfunction not only furthers the understanding of dopamine-acetylcholine relationships in cognitive function, it also suggests a promising direction for the development of treatments for cognitive dysfunction due to cholinergic loss.     

Effects of aging and task difficulty on divided attention performance

We report two experiments that compare the performance of young and older adults on perceptual-motor tasks involving division of attention. Previous studies have shown older people to be especially penalized by divided attention situations, but the generality of this finding was recently challenged by Somberg and Salthouse (1982). The present study was conducted to investigate the possibility that age differences in dual-task performance are amplified by an increase in the difficulty of the constituent tasks, where difficulty was manipulated by varying the central, cognitive nature of the tasks (Experiment 1) or the degree of choice involved (Experiment 2). With the present tasks, strong evidence was found for an age-related decrement in divided attention performance. Contrary to our original expectations, however, it does not seem that division of attention presents some especial difficulty to older people. Rather, division of attention is one of several equivalent ways to increase overall task complexity. In turn, age differences are exaggerated as tasks are made more complex.     

S-R compatibility between response position and destination of apparent motion: evidence of the detection of affordances

In choice reaction time, stimuli and responses in some combinations (e.g., based on spatial arrangement) are faster than in other combinations. To test whether motion toward a position yields faster responses at that position, a computer-generated square in front of one hand appeared to move either toward that hand or toward the other hand. Compatible responses (e.g., motion toward left hand/left response) were faster than incompatible responses, even when that opposed traditional positional compatibility. In Experiment 2, subjects responded to the same stimuli but with both hands left, right, or on the body midline. Medial responses were the fastest, showing that destination, rather than mere relative position, was a critical variable. It was suggested that spatial compatibility effects are not unique to position but apply to a variety of task situations, describable by J.J. Gibson's theory of affordances, in which he claims that one perceives the actions (e.g., catching) permitted in a situation.     

Understanding the central processing limit in consistent-mapping visual search tasks

Effects of load (i.e., the number of stimuli in the display) have been observed in multiple-frame studies using a consistent mapping of stimuli to responses (e.g., Fisher, 1982, 1984). In a series of four experiments, it is shown that these effects are not the consequence of differences across the high- and low-load conditions in either decision noise or peripheral masking. Additionally, it is shown that of two modes of limited capacity (a limited-channel and divided-capacity model) considered as possible explanations of load effects in tasks where subjects are required to locate a target, only one--the limited-channel model--is consistent with the results from all three location tasks. Finally, it is argued that the limited-channel model predicts not only the behavior observed in the four consistent-mapping experiments reported in this article but also the behavior observed in several related consistent-mapping tasks (Kleiss & Lane, 1986; Shiffrin & Gardner, 1972).     

Mental rotation: effects of dimensionality of objects and type of task

The original studies of mental rotation estimated rates of imagining rotations that were much slower when two simultaneously portrayed three-dimensional shapes were to be compared (R. Shepard & J. Metzler) than when one two-dimensional shape was to be compared with a previously learned two-dimensional shape (Cooper and her associates). In a 2 X 2 design, we orthogonally varied dimensionality of objects and type of task. Both factors affected reaction times. Type of task was the primary determiner of estimated rate of mental rotation, which was about three times higher for the single-stimulus task. Dimensionality primarily affected an additive component of all reaction times, suggesting that more initial encoding is required for three-dimensional shapes. In the absence of a satisfactory way of controlling stimulus complexity, the results are at least consistent with the proposal that once three-dimensional objects have been encoded, their rotation can be imagined as rapidly as the rotation of two-dimensional shapes.     

Representation of serial order in monkeys (Cebus apella)

Cebus monkeys were trained on a five-item serial learning task, symbolized as ABCDE; the initial stages of training were on the shorter subseries AB, ABC, and ABCD. To assess the monkeys' knowledge of the sequential position of each item, pair-wise tests were given to 2 subjects after acquisition of the ABCD series and to 4 subjects after reaching criterion on the ABCDE series. In both tests, the monkeys performed at high levels on the interior pairs, which were BC for the ABCD series, and BC, BD, and CD for the ABCDE series. These results, as well as the orderly relations observed in the pair-wise tests between first-item response latency and first-item position and between second-item response latency and number of missing items, indicated that the monkeys had developed a well-organized internal representation of the four- and five-item series. Although pigeons are also capable of learning four-item and five-item series, they apparently do not develop a comparable representational structure. The disparity between the monkeys' and pigeons' representational competence for serial order is predictable from the difference in their capacities for associative transitivity.     

Affective state mediates causal attributions for success and failure

The influence of affect on causal attributions for success and failure was examined in this experiment. A positive, neurtral, or negative mood was induced in subjects who then learned they had either succeeded or failed an aptitude test taken previously. Relative to neutral mood control conditions, subjects in both positive and negative mood conditions showed a pronounced self-serving bias, particularly following success. The finding is interpreted as self-regulation of affective state. Specifically, causal attribution of success to internal factors can sustain or enhance positive affect; attribution of failure to external factors can diminish negative affect. Ancillary analyses corroborated this interpretation.     

Race and Moral Judgment Development Scores

Black and White college students were studied to determine reactions to moral dilemmas when the race of the central character in the dilemma was changed.