Measurement and interpretation of the mismatch negativity

The mismatch negativity (MMN) is a preattentive brain response elicited by changes in repetitive auditory stimulation. Usually, it is identified as the difference between the event-related potential elicited by a high-probabilitystandard and that elicited by a low-probabilitydeviant stimulus. Most likely, MMN is generated by the outcome of a comparison process that registers a difference between the neural representation of the actual input and the memory trace of the standard stimulation. Since its discovery by Näätänen and colleagues in 1978, MMN has become a useful tool for investigating the brain’s auditory information processing in several hundred studies. The present paper describes problems related to the measurement and interpretation of MMN. First, it reviews important features of MMN. Second, it provides technical information about recording and parametrization of this brain wave. Third, it discusses various methodological aspects which may be taken into account in the designing of MMN experiments. Fourth, it addresses some conceptual problems that have to be considered in the proper interpretation of MMN.     

Moral Relativism

Moral relativism comes in many varieties. One is a moral doctrine, according to which we ought to respect other cultures, and allow them to solve moral problems as they see fit. I will say nothing about this kind of moral relativism in the present context. Another kind of moral relativism is semantic moral relativism, according to which, when we pass moral judgements, we make an implicit reference to some system of morality (our own). According to this kind of moral relativism, when I say that a certain action is right, my statement is elliptic. What I am really saying is that, according to the system of morality in my culture, this action is right. I will reject this kind of relativism. According to yet another kind of moral relativism, which we may call epistemic, it is possible that, when one person (belonging to one culture) makes a certain moral judgement, such as that this action is right, and another person (belong to another culture) makes the judgement that the very same action is wrong, they may have just as good reasons for their respective judgements; it is even possible that, were they fully informed about all the facts, equally imaginative, and so forth, they would still hold on to their respective (conflicting) judgements. They are each fully justified in their belief in conflicting judgements. I will comment on this form of moral relativism in passing. Finally, however, there is a kind of moral relativism we could call ontological, according to which, when two persons pass conflicting moral verdicts on a certain action, they may both be right. The explanation is that they make their judgements from the perspective of different, socially constructed, moral universes. So while it is true in the first person's moral universe that a certain action is right, it is true in the second person's moral universe that the very same action is wrong. I explain and defend this version of ontological moral relativism.     

Zur Dynamik der Interaktion in der Supervision

The manifold functions of a supervisor in following the course of complex processes together with the trainee, are: ? to keep the goals of the supervision in view, ? to establish a teaching alliance and to support the wish and ambitions of the candidate to learn, ? to build a platform for the complex interactions with the trainee with regard to the dynamics of the training situation and keeping in mind the institutional influences, ? to lay down the setting for the work, ? to explore and to reflect how transference and counter-transference influence the interaction between patient and analyst as well as between trainee and supervisor, ? to examine these interactions together focussing continuously on the interaction between candidate and patient, and to encourage the candidate to do the same on his own, ? to continuously formulate hypotheses about the core conflict, the transference phenomena and resistance of the patient, ? to explore and reflect on the cooperative work.     

Stimulus-dependent dopamine release in attention-deficit/hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is related to an attenuated and dysfunctional dopamine system. Normally, a high extracellular dopamine level yields a tonic dopaminergic input that down-regulates stimuli-evoked phasic dopamine responses through autoreceptors. Abnormally low tonic extracellular dopamine in ADHD up-regulates the autoreceptors so that stimuli-evoked phasic dopamine is boosted. The authors propose that these boosted phasic responses yield hypersensitivity to environmental stimuli in ADHD. Stimuli evoking moderate brain arousal lead to well-functioning performance, whereas either too little or too much stimuli attenuate cognitive performance. Strong, salient stimuli may easily disrupt attention, whereas an environment with impoverished stimuli causes low arousal, which is typically compensated for by hyperactivity. Stochastic resonance is the phenomenon that makes a moderate noise facilitate stimulus discrimination and cognitive performance. Computational modeling shows that more noise is required for stochastic resonance to occur in dopamine-deprived neural systems in ADHD. This prediction is supported by empirical data.     

Perspective effects in repeated reading: An eye movement study

The present study examined the influence of perspective instructions on online processing of expository text during repeated reading. Sixty-two participants read either a high or a low prior knowledge (HPK vs. LPK) text twice from a given perspective while their eye movements were recorded. They switched perspective before a third reading. Reading perspective affected the first-pass reading and also increased sentence wrap-up processing time in the perspective-relevant sentences. Prior knowledge facilitated the recognition of the (ir)relevance of text information and resulted in relatively earlier perspective effects in the HPK versus LPK text. Repeated reading facilitated processing, as indicated by all eye movement measures. After the perspective switch, a repetition benefit was observed for the previously relevant text information, whereas a repetition cost was found for the previously irrelevant text information. These results indicate that reading perspective and prior knowledge have a significant influence on how readers allocate visual attention during reading.     

Family perception of interpersonal behavior as a predictor in eating disorders: a prospective, six-year followup study

This study assessed family perception patterns of interpersonal behavior in families with a daughter diagnosed with an eating disorder 6 years after treatment that used a prospective design. Family perception patterns of patients found to have a poor outcome at followup (n = 15) were compared with patients with a good outcome (n = 23), as well as a control group (n = 36). Using the system of multiple level observation of groups (SYMLOG), all 238 family members evaluated themselves and each other. The index patients with a poor outcome perceived themselves as friendlier and more positive than they were perceived by their families. In comparison to parents of daughters with a good outcome and the control group, parents of daughters in the poor outcome group perceived themselves to be less friendly than their partners perceived them to be. A rigid polarization of the perception of the index patient by family members and a discrepancy in this perception between the index patient and the rest of the family were found to be indicative of a poor prognosis. Implications for treatment based on family perception patterns of interpersonal behavior are discussed.     

Dimensional complexity and power spectral measures of the EEG during functional versus predicative problem solving

Electroencephalograms were recorded in 22 men while solving tasks of visual-pattern completion and during mental relaxation. They were primed (by foregoing trials) to solve these tasks either in a predicative or functional mode of thinking. Predicative thinking required that in order to complete the pattern the subject had to get involved with the logic of the static structure of the pattern and therefore had to recognize the recurrence of certain features of the elements (e.g., shape, color, and size). Functional thinking required involvement in a dynamic reading of the logic of the pattern and therefore to search for operations and actions to be performed on the pattern elements (e.g., pushing, mirroring, and rotating). The EEG complexity during predicative thinking decreased in comparison to functional thinking and mental relaxation, with this reduction being most pronounced over the right parietal cortex. A reduction in dimensional complexity during functional thinking as compared to mental relaxation, which was concentrated over the left central cortex, although significant, was less clear. The reduced EEG complexity during predicative thought, dominant over the right hemisphere, could reflect increased competitive inhibition among respective cortical neuron assemblies in association with the visual analysis of static element features, converging upon those predicates relevant for the solution.