A note on further experiments on the effects of meprobamate on discrimination performance in the monkey

A previous experiment (Gross and Weiskrantz, 1961) has shown that performance on a successive auditory discrimination task is impaired by injections of meprobamate. The present two brief experiments indicate that the drug also impairs simultaneous visual discrimination performance, although not to the same degree as found earlier for auditory discrimination. The original finding, therefore, cannot be attributed simply to unique features of the auditory discrimination situation, such as the “go—no-go” response contingency. Since neither overtraining nor drug habituation appears to be of great importance, it is suggested that the lesser effect of the drug in these experiments reflects the greater stability of visual than auditory habits in the monkey.

Earlier work has shown that meprobamate and reserpine can cause a severe deterioration in auditory discrimination performance of monkeys (Gross and Weiskrantz, 1961). This result was taken as supporting a hypothesis, growing out of still earlier research, that tranquillizers decrease the utilization of sensory information (Weiskrantz and Wilson, 1956; Weiskrantz, 1957).

The auditory task, as is almost always the case with monkeys as subjects, involved a “go—no-go” type of response contingency—i.e. the animal had to respond to the positive stimulus and had not to respond to the negative stimulus in order to achieve reward. It might be objected, therefore, that the deterioration in performance was associated not with discrimination as such but with the animals' willingness to perform at all. In fact, it was found that the animals tended to make most of their errors under the drugs by responding when they should not rather than not responding when they should.

The purpose of the present experiments, therefore, was to test the animals with a visual discrimination task in which both the positive and negative stimuli were presented simultaneously. An effect of the drug could not, in this situation, be characterized simply as altering the responsiveness of the animal. A further purpose in using visual stimuli was to test the generality of the earlier finding in a sense modality other than audition.     

Behavioral case formulation: An experimental assessment study of transient tic disorder

A nine-year-old male, who met DSM III-R criteria for transient tic disorder, participated in an experimental assessment strategy to generate support for a case formulation. In addition to presenting motor disturbance, assessment procedures revealed six problem areas. All problems were formulated as manifestations of a hypersensitivity to evaluation, etiologically related to the boy's relationship with an insecure and critical father. It was hypothesized that the patient's tic disorder was a consequence of his hypersensitivity to father's excessive criticism, which then generalized to other evaluative situations. Using a controlled single-subject design, predictions derived from the formulation were tested by exposing the child to a planned combination of evaluative observers (e.g., father, mother, therapist, etc.) who watched him as he worked on a series of puzzles. The dependent measures included (1) behavioral recordings of tic frequency and (2) frontalis EMG responses. The results indicated significant differences in tic rate and EMG as a function of the type of observer. Consistent with the formulation, the patient displayed the highest levels of tic behavior and EMG response when his father was the observer and lowest in the presence of the mother. Predictions regarding other stimulus conditions were also confirmed. These results provided support for the case formulation that was used to design an effective treatment intervention. Findings suggest that the case formulation model offers a method whereby novel case hypotheses can be generated for poorly understood psychopathology and tested later in the experimental situation.     

The etiology of schizophrenia as perceived by psychiatrists in Europe and the United States

This paper compares and contrasts statements made by American and European psychiatrists on the etiology of schizophrenia. In the U.S., leading figures in psychiatry hold increasingly to the view that the disorder is physiogenic at source—from which it seems to follow that the appropriate treatments should similarly focus on physiological and pharmacological therapies. In contrast, European psychiatrists seem to be divided in support for organic and psychodynamic explanations. Some European writers have pointedly warned against over-interpreting recent studies which seem to point to specific organic dysfunctions and deficits as schizophrenogenic. This paper was presented at the Second Annual Convention of the American Psychological Society, Dallas, Texas, June 7–10, 1990.     

A novel automatic procedure for measuring ocular counterrolling: A computeranalytical method to determine the eye’s roll angle while subjects work on perceptual tasks

In investigations of the perception of space, the consideration of ocular counterrolling-the movement of the eye around its visual axis in response to body movement-is crucially important. The angle of this movement must be known in order for one to determine the precise retinal coordinates of a distal object. Following transformation, this stimulus serves as a reliable cue for visual direction. The otolith organs provide information about body tilt and are responsible for ocular counterrolling. A novel, noninvasive method to measure ocular counterrolling, based on the cross-correlation of digitized video pictures of the eyes, is presented. The resolution attained was ≤ 0.1°. The computer analysis is fully automatic and fast, and it can be performed while subjects work on perceptual tasks. No direct access to the eyeballs is required. Data from 4 subjects showing the counterrolling profile in various body positions are presented.     

Small Wins: Perceptual Focus,Efficacy, and Cooperation in a Stage-Conjunctive Social Dilemma1

A multi-stage social dilemma was used to explore the notion that focusing on part rather than all of a complex problem would affect self-efficacy and action. In two experiments subjects considered a multi-stage game asking them to invest an initial sum of money in hopes of earning a larger bonus to be paid if provision points were met at all stages (a “stage-conjunctive” task). Results indicated that under most conditions considered, presentation of the whole problem encouraged cooperation. The opposite pattern occurred when group members were asked to complete very demanding stages first. We suggest that these results depend strongly on the stage-conjunctive nature of our task.     

Salience of rape affects self-esteem: The moderating role of gender and rape myth acceptance

In two experiments, conducted in Germany and the U.S.A., it was found that exposure to a rape report lowered self-esteem and positive affect in women who do not accept ‘rape myths’ (stereotypical beliefs which blame the victim and exonerate the rapist; Burt, 1980). Men high in rape myth acceptance (RMA) showed an increase in positive affect and self-esteem as a function of exposure to rape; men low in RMA and women high in RMA were largely unaffected. Both experiments demonstrated that these effects were specific to rape, as opposed to violence in general. These results support the feminist hypothesis that the threat of rape serves the function to exert social control over women and to sustain men's dominance. Potential cognitive mechanisms mediating the observed effects are discussed.     

Naming consistency in Alzheimer''s disease

Although lexical semantic deficits are postulated to play a prominent role in the anomia of Alzheimer's disease, it is unclear whether the primary disturbance is one of lexical access or one of lexical semantic loss. Response consistency on a naming task is one means of evaluating the underlying source of naming impairment. Access dysfunction usually implies variable word-finding difficulty, while a theory of lexical loss predicts that many word names would be consistently unavailable. Nineteen Alzheimer's disease patients were administered a visual confrontation naming task (the Boston Naming Test) on two occasions 6 months apart. Eighty percent of errors occurred consistently at both times; only 20% of errors occurred on only one occasion. Response consistency occurred significantly more often than expected under the assumption of no response consistency. Findings support the hypothesis that anomia in Alzheimer's disease is in part due to a loss of lexical semantic information.     

Differences in Personality Disorders and Family-of-Origin Characteristics for Male and Female Alcoholics: Implications for Treatment

This study investigated the personality and family-of-origin differences in male and female alcoholics. Results indicated that, regarding personality, men (both type 1 and type 2) were less troubled than were women. Implications for treatment based on these results are included.     

Ninety-three pictures and 108 questions for the elicitation of homophones

Homographs and homophones have interesting linguistic properties that make them useful in many experiments involving language. To assist researchers in the elicitation of homophones, this paper presents a set of 93 line-drawn pictures of objects with homophonic names and a set of 108 questions with homophonic answers. Statistics are also included for each picture and question: Picture statistics include name-agreement percentages, dominance, and frequency statistics of depicted referents, and picture-naming latencies both with and without study of the picture names. For questions, statistics include answer-agreement percentages, difficulty ratings, dominance, frequency statistics, and naming latencies for 60 of the most consistently answered questions.