Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Neurodegen erative disorders such as Alzheimer’s disease (AD) are increasingly threatening public health. Most animal models of AD consist of transgenic mice that are usually housed singly or in unisexual groups in small barren cages. Such restricted environments, however, prevent the mice from showing a variety of speciesspecific behaviors and consequently may constrain comprehensive behavioral phenotyping. On the other hand, allowing the animals to freely organize their lives in a spacious physically and socially enriched environment makes behavioral phenotyping laborious and time consuming. Radio frequency identification (RFID) using a network of antennae and small glass-coated transponders labeling each individual allows for gathering spatiotemporal information about a large number of individuals in parallel. The aim of this project was to use the RFID technique to facilitate the characterization of mice carrying a genetic disposition to develop AD-like pathology and of their wild-type conspecifics in a spacious seminaturalistic environment.     

Accessibility experiences and the hindsight bias: I knew it all along versus it could never have happened

In two experiments, we tested accessibility experiences versus accessible content in influencing the hindsight bias when participants generated either thoughts about alternative outcomes or thoughts about known outcomes. Participants who had listed many thoughts (Experiment 1) and those who had contracted their brow muscles (Experiment 2) when considering alternate outcomes rated the known outcome as more likely than did than those who had listed two thoughts or who had not contracted their brows--a "backfire" effect. In contrast, but no less ironically, participants who had listed many thoughts and those who contracted their brows when considering known outcomes rated those outcomes as less likely--an "it could never have happened" effect. Both effects are due to subjective accessibility experiences, and their role in influencing and debiasing the hindsight bias is discussed.     

“How Many Partners Is Too Many?” Shaping Perceptions of Personal Vulnerability1

The effectiveness of interventions that directly inform people of the risks posed by their own behavior is frequently undermined by people's ability to defend themselves against unwanted information. In response to this difficulty, an alternative approach to shaping people's perceptions of personal vulnerability in which people remained unaware of the intervention was tested. As part of a survey on sexual issues, college undergraduates reported the total number of sexual partners they had had on a response scale that systematically framed their sexual behavior as being either above average or below average. Participants in the 2 conditions reported the same absolute number of sexual partners. However, those who received a response scale that implied they had had more partners than the average student reported greater concern about their sexual behavior than did those who received a scale that implied they had had fewer partners than average. The implications of this approach for influencing perceptions of personal risk are discussed.