Longitudinal Results of Cognitive Behavioral Treatment for Youths with Inflammatory Bowel Disease and Depressive Symptoms

Youths with chronic physical illnesses face increased rates of psychological problems and the burden of coping with physical illness-related challenges. The following data describes treatment outcome maintenance results from a randomized clinical trial investigating the impact of a cognitive behavioral intervention Primary and Secondary Control Enhancement Therapy-Physical Illness (PASCET-PI) as compared to treatment as usual (TAU) on youths with inflammatory bowel disease (IBD). Forty-one participants aged 11-17 with IBD and concurrent depressive symptomatology were randomized to PASCET-PI (n?=?22) or TAU (n?=?19). Self-reported depressive features, global functioning, and DSM-IV depressive symptomatology were assessed immediately post-treatment (T2), followed by assessments at 6-months (T3) and 12-months (T4) post-treatment initiation. Repeated measure models revealed significantly improved global psychosocial functioning in youths randomized to PASCET-PI compared to youths randomized to TAU. Improvements in self-reported depressive features and DSM-IV depressive symptoms were found at the trend level for youths randomized to PASCET-PI relative to those receiving TAU. Effect size estimates for all outcome variables suggested large to medium treatment effects.     

CNS prophylaxis of childhood leukemia: What are the long-term neurological,neuropsychological, and behavioral effects?

Current medical treatments for childhood acute lymphoblastic leukemia (ALL) have improved the outlook to where more than 50% can be expected to survive five years or more. The use of CNS prophylaxis has contributed in a significant way to these improved survival statistics by reducing the likelihood of CNS relapses. The literature relating to the potential adverse psychological consequences of CNS prophylaxis, which include cranial radiation therapy (CRT), is reviewed and analyzed. The majority of published papers of children in first remission report that CNS prophylaxis, which include both CRT and intrathecal methotrexate, results in a variety of learning problems in many children who were younger than age 5 when treated. The available literature on the social, emotional, and educational sequelae of childhood ALL is also reviewed.Contributing Childrens Cancer Study Group investigators, institutions, and grant numbers are given in the Appendix. Address reprint requests to the Childrens Cancer Study Group, 440 East Huntington Drive, Suite 300, P.O. Box 60012, Arcadia, California 91066-6012.     

Functional magnetic resonance imaging: Overview and methods for psychological research

Functional magnetic resonance imaging (fMRI) allows noninvasive imaging of hemodynamic changes related to neural activity. This technique can be used in single-subject designs and can provide millimeter spatial resolution and temporal resolution in the range of 5–10 sec. This paper provides a brief introduction to MRI techniques and their application to functional neuroimaging, focusing on methodological issues that are of particular concern to psychologists, including methods for presenting computerized stimuli to subjects without disrupting the scanner, experimental design issues, and statistical analysis and image processing procedures. To illustrate methodological issues, recent results from a series of studies looking at the topographic organization of visual cortex are presented. General issues concerning limitations in this technique, future directions in its development, its relationship to other neuroimaging techniques, and the role of functional neuroimaging in psychological research are addressed in the Discussion.     

Predicting Treatment Response for Oppositional Defiant and Conduct Disorder Using Pre-Treatment Adrenal and Gonadal Hormones

Variations in adrenal and gonadal hormone profiles have been linked to increased rates of oppositional defiant disorder (ODD) and conduct disorder (CD). These relationships suggest that certain hormone profiles may be related to how well children respond to psychological treatments for ODD and CD. The current study assessed whether pre-treatment profiles of adrenal and gonadal hormones predicted response to psychological treatment of ODD and CD. One hundred five children, 6–11?years old, participating in a randomized, clinical trial provided samples for cortisol, testosterone, dehydroepiandrosterone, and androstenedione. Diagnostic interviews of ODD and CD were administered up to 3?years post-treatment to track treatment response. Group-based trajectory modeling identified two trajectories of treatment response: (1) a High-response trajectory where children demonstrated lower rates of an ODD or CD diagnosis throughout follow-up, and (2) a Low-response trajectory where children demonstrated higher rates of an ODD or CD diagnosis throughout follow-up. Hierarchical logistic regression predicting treatment response demonstrated that children with higher pre-treatment concentrations of testosterone were four times more likely to be in the Low-response trajectory. No other significant relationship existed between pre-treatment hormone profiles and treatment response. These results suggest that higher concentrations of testosterone are related to how well children diagnosed with ODD or CD respond to psychological treatment over the course of 3?years.     

The “Islamized Stranger”: On “Chronic” Versus “Contextual” Salience in the Measurement of Anti‐Muslim Prejudice

There is an ongoing debate whether anti‐Muslim prejudice in Western countries is more widespread than prejudice towards other ethno‐cultural groups or general ethnic prejudice. Previous research used different methodologies and yielded contradictory results. In this article, we combine a population‐based split‐sample survey experiment (N = 1,323), where half of the respondents judged items about Muslims and the other half statements about strangers, with an open question probing which groups respondents thought of when thinking about “strangers.” We furthermore extend previous research by not only focusing on general ethnic prejudice, but to differentiate between perceived trustworthiness, economic, cultural, and security threat. Our results strongly support the idea that the difference between the “chronic” and “contextual” salience of the target of prejudice should be taken into account.     

Functional lateralization of the human premotor cortex during sequential movements

A neurological truism is that each side of the brain controls movements on the opposite side of the body. Yet some left hemisphere brain lesions cause bilateral impairment of complex motor function and/or ideomotor apraxia. We report that the left dorsal premotor cortex of normal right-handed people plays a fundamental role in sequential movement of both right and left hands. Subjects performed sequential finger movements during functional magnetic resonance imaging of the motor cortices. In right-handed subjects, the volume of activated dorsal premotor cortex showed a left hemispheric predominance during hand movements. We suggest that the observed left premotor dominance contributes to the lateralization found in lesion studies.     

Peer relationships and emotional well-being of children with sickle cell disease: a controlled replication.

We completed a replication study examining the social and emotional functioning of children with sickle cell disease (SCD) who have not had an overt stroke and a group of demographically similar comparison classmates based upon data from multiple informants. Relative to comparison peers, children with SCD were described by teachers as more prosocial and less aggressive. Peers described them as having fewer friends, less athletic, ill more often, and missing more school. No group differences were identified for emotional well-being. Effect size analyses indicated that this study replicated a number of findings from our previous study of children with SCD (Noll et al., 1996). Findings from both studies suggest relative psychological hardiness among children with SCD who have not had an overt stroke.     

Impact of Depression and Childhood Trauma in Mothers Receiving Home Visitation

Research has documented the deleterious effects of maternal depression and childhood trauma on parenting and child development. There are high rates of both depression and childhood trauma in new mothers participating in home visitation programs, a prevention approach designed to optimize mother and child outcomes. Little is known about the impacts of maternal depression and childhood trauma on parenting in the context of home visitation. This study contrasted depressed and non-depressed mothers enrolled in the first year of a home visitation program on parenting stress, quality of home environment, social network, and psychiatric symptoms. Mothers were young, low income, and predominantly unmarried. Results indicated that depressed mothers displayed impairments in parenting, smaller and less robust social networks, and increased psychiatric symptoms relative to their non-depressed counterparts. Path analyses for the full sample revealed a path linking childhood trauma, depression, and parenting stress. Path analyses by group revealed several differential relationships between dimensions of social network and parenting. Number of embedded networks, namely the number of different domains in which the mother is actively interacting with others, was associated with lowered parenting stress among non-depressed mothers and increased parenting stress in their depressed counterparts with childhood trauma histories. In depressed mothers, social network size was associated with lower levels of parenting stress but decreased quality of the home environment, whereas number of embedded networks was positively related to quality of the home environment. Implications of findings for home visitation programs are discussed.