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Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus 下载免费PDF全文
Stress facilitates memory formation, but only when the stressor is closely linked to the learning context. These effects are, at least in part, mediated by corticosteroid hormones. Here we demonstrate that corticosterone rapidly facilitates synaptic potentiation in the mouse hippocampal CA1 area when high levels of the hormone and high-frequency stimulation coincide in time, but not when corticosterone is given either before or after repetitive stimulation. This effect could not be blocked by antagonists of the mineralocorticoid receptor and glucocorticoid receptor (spironolactone and RU 38486, respectively). These data provide a biological substrate for the important behavioral observation that stress and corticosteroid hormones can facilitate learning and memory processes. 相似文献
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Palchykova S Winsky-Sommerer R Meerlo P Dürr R Tobler I 《Neurobiology of learning and memory》2006,85(3):263-271
Many studies in animals and humans suggest that sleep facilitates learning, memory consolidation, and retrieval. Moreover, sleep deprivation (SD) incurred after learning, impaired memory in humans, mice, rats, and hamsters. We investigated the importance of sleep and its timing in an object recognition task in OF1 mice subjected to 6h SD either immediately after the acquisition phase (0-6 SD) or 6h later (7-12 SD), and in corresponding undisturbed controls. Motor activity was continuously recorded with infrared sensors. All groups explored two familiar, previously encountered objects to a similar extent, both at the end of the acquisition phase and 24h later during the test phase, indicating intact familiarity detection. During the test phase 0-6 SD mice failed to discriminate between the single novel and the two familiar objects. In contrast, the 7-12 SD group and the two control groups explored the novel object significantly longer than the two familiar objects. Plasma corticosterone levels determined after SD did not differ from time-matched undisturbed controls, but were significantly below the level measured after learning alone. ACTH did not differ between the groups. Therefore, it is unlikely that stress contributed to the memory impairment. We conclude that the loss of sleep and the activities the mice engaged in during the SD, impaired recognition memory retrieval, when they occurred immediately after acquisition. The delayed SD enabled memory consolidation during the 6h when the mice were allowed to sleep, and had no detrimental effect on memory. Neither SD schedule impaired object familiarity processing, suggesting that only specific cognitive abilities were sensitive to the intervention. Sleep may either actively promote memory formation, or alternatively, sleep may provide optimal conditions of non-interference for consolidation. 相似文献
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What information is used for sorting pictures of complex stimuli into categories? We applied a reverse correlation method to reveal the visual features mediating categorization in humans and baboons. Two baboons and 6 humans were trained to sort, by species, pictures of human and baboon faces on which random visual noise was superimposed. On ambiguous probe trials, a human-baboon morph was presented, eliciting "human" responses on some trials and "baboon" responses on others. The difference between the noise patterns that induced the two responses made explicit the information mediating the classification. Unlike the humans, the baboons based their categorization on information that closely matched that used by a theoretical observer responding solely on the basis of the pixel similarities between the probe and training images. We show that the classification-image technique and principal components analysis provide a method to make explicit the differences in the information mediating categorization in humans and animals. 相似文献
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Mariëlle Stel Jim Blascovich Cade McCall Jessanne Mastop Rick B. van Baaren Roos Vonk 《European journal of social psychology》2010,40(5):867-880
The sharing of bodily states elicits in mimicker and mimickee corresponding conceptualisations, which facilitates liking. There are many studies showing the relatedness of mimicry and liking. However, the mimicry‐liking link has not been investigated under conditions in which the mimickee is liked or disliked a priori. In two studies, we examined moderating effects of a priori liking on the mimicry‐liking link. Liking was measured via self‐report measures (Studies 1 and 2) and behavioural measures using a virtual environment technology (Study 2). Results showed that when participants intentionally mimicked a disliked person, liking for that person was not improved, whereas when participants mimicked a liked person, liking for that person increased. These effects were shown to be mediated by affiliation. These studies not only provided further evidence of a link between mimicry and liking, but also demonstrated that this relationship is moderated by a priori liking. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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Juliette Gatto Michaël Dambrun Christian Kerbrat Pierre De Oliveira 《European journal of social psychology》2010,40(2):252-269
The principal aim of this study is to determine why police officers are generally found to be more prejudiced towards disadvantaged groups than are the standard population. Two independent processes were expected to account for this effect: Selection and group socialisation. Using a cross‐sectional design (N = 170), firstly, we compared, newly recruited police officers with a control population (selection effect), and secondly, police officers with 1 year of training with the newly recruited ones (group socialisation effect). Results reveal a significant effect of both selection and group socialisation, the two being underlined by distinct processes; right‐wing authoritarianism (RWA) in the case of the former and internalisation of a prejudice norm in the case of the latter. Finally, the results show that group identification moderates the change in internalisation of the prejudice norm. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献