Comparative clinicogenetic study of schizophrenic psychoses

The author diagnoses 350 carefully selected schizophrenic subjects, their parents and their siblings during parallel studies using three different clinical classification systems and analyzes the results by multiple threshold analysis and the multifactorial inheritance model. The results suggest that, of the three classifications the author studied, Leonhard's and Sneshnewski's system yield relatively homogeneous subgroups; this indicates the future significance of these nosological systems for the planning of biopsychiatric research.     

Lay conceptions of personality: Eliciting tiers of a scientific conception of personality

Two studies are reported which examine the availability of scientific propositions of personality in lay conceptions of personality. It is argued from a social constructivist perspective that models of personality must derive from and refer to lay conceptions of persons. Eysenck's trait-type model of introversion-extraversion, containing specific propositions about phenotypic and genotypic differences between extraverts and introverts, was utilized as the scientific model of personality and its availability in lay conceptions of personality was examined in two studies. In the first study, subjects were presented with a genotypic characterization of either an introvert or an extravert target person and asked to infer corresponding phenotypic differences. In the second study, the inference process was reversed with subjects being asked to infer genotypic characteristics of introverts versus extraverts on the basis of phenotypic target person desecrations of the two types. Results from both studies show a high degree of accuracy in subjects' inferences, suggesting that laypersons have well-formed conceptions about personality containing ‘higher-order’ psychogenetic propositions corresponding to Eysenck's trait-type model. The implications of the findings for theory construction are discussed.     

Social structure features in three inbred strains of mice, C57Bl/6J, Balb/cj, and NIH: a comparative study

Some features of social living were investigated in three inbred strains of mice: C57Bl/6j, Balb/cj, and NIH. Five social behaviors--Aggression, Submission, Allogrooming, Social Rest and Rest Alone, as well as Wheel Running Activity--were recorded 2 h daily for a week, in 26 groups of seven male mice living in an enriched environment. Dominants and subordinates among strains shared some behavioral characteristics, but strain contributions upon social structure were also detected. Similarities among strains included the appearance of a single dominant mouse per group rated as the most aggressive, besides from being the animal presented with most Submissions. Allogrooming was more frequent among subordinates than among dominants and subordinates. Differences among strains were that agonistic behavior among subordinates was higher in the Balb/cj and NIH groups than in the C57Bl/6j mice. NIH mice were recorded in Rest Alone more often than mice from the other strains. C57Bl/6j dominants showed higher rates of Wheel Running Activity than subordinates.     

On structural equation modeling with data that are not missing completely at random

A general latent variable model is given which includes the specification of a missing data mechanism. This framework allows for an elucidating discussion of existing general multivariate theory bearing on maximum likelihood estimation with missing data. Here, missing completely at random is not a prerequisite for unbiased estimation in large samples, as when using the traditional listwise or pairwise present data approaches. The theory is connected with old and new results in the area of selection and factorial invariance. It is pointed out that in many applications, maximum likelihood estimation with missing data may be carried out by existing structural equation modeling software, such as LISREL and LISCOMP. Several sets of artifical data are generated within the general model framework. The proposed estimator is compared to the two traditional ones and found superior.The research of the first author was supported by grant No. SES-8312583 from the National Science Foundation and by a Spencer Foundation grant. We wish to thank Chuen-Rong Chan for drawing the path diagram.     

Three-dimensional perspective drawing of two-dimensional functions with microcomputers

In this paper, we present a BASIC program for Apple II series computers that allows the user to obtain perspective drawings of two-dimensional functions of known analytical expression. Also, we outline a procedure for obtaining perspective representations of two-dimensional arrays of data using the same program. The program should run on any computer with graphics mode with only slight modifications in the graphics commands.     

Some problems of genetic counseling in schizophrenic psychoses

The authors sum up the most important basic principles of diagnostics and genetics of the schizophrenic psychoses from the viewpoint of genetic counseling for the practising psychiatrist and medical geneticist. Regarding genetic counselling strategy, in addition to nosological considerations, they stress the importance of socio-cultural and social psychological factors and of the emotional atmosphere in the family, which should all be taken into account together. Because of the special situation of schizophrenic (and in general, psychiatric) patients and their families, they regard it as advisable to set up a separate psychiatric genetic counselling service.     

Maps between some different kinds of contraction function: The finite case

In some recent papers, the authors and Peter Gärdenfors have defined and studied two different kinds of formal operation, conceived as possible representations of the intuitive process of contracting a theory to eliminate a proposition. These are partial meet contraction (including as limiting cases full meet contraction and maxichoice contraction) and safe contraction. It is known, via the representation theorem for the former, that every safe contraction operation over a theory is a partial meet contraction over that theory. The purpose of the present paper is to study the relationship more finely, by seeking an explicit map between the component orderings involved in each of the two kinds of contraction. It is shown that at least in the finite case a suitable map exists, with the consequence that the relational, transitively relational, and antisymmetrically relational partial meet contraction functions form identifiable subclasses of the safe contraction functions, over any theory finite modulo logical equivalence. In the process of constructing the map, as the composition of four simple transformations, mediating notions of bottom and top contraction are introduced. The study of the infinite case remains open.     

Concept learning,memory and transfer of dot pattern categories

In the first experiment, subjects rated the similarity of a sample of pairs of random dot patterns generated from 3 prototypes consisting of either 4, 6, or 9 dots. The results of the experiment tended to confirm the structure imposed on the patterns by the construction method. In the second experiment, subjects learned to classify random patterns generated from 2 prototypes with either short or long interprototype distance and consisting of either 4, 6, or 9 dots in a traditional concept identification task. After acquisition, memory for old and new distortions and the prototype, which was not presented during learning, was assessed. The tendency to call a pattern “new” increased with the distance between the pattern and its prototype. In a subsequent transfer test, all subjects saw patterns of either 4, 6, or 9 dots. Performance was above chance and the transfer from larger to smaller patterns tended to be greater than the transfer from smaller to larger patterns. This is consistent with a process of schema formation based on features common to most exemplars of the category. The results are discussed in relation to several theories of concept learning and schema abstraction.