Examining the Ethics of Clinical Use of Unproven Interventions Outside of Clinical Trials During the Ebola Epidemic

The recent Ebola outbreak in West Africa began in the spring of 2014 and has since caused the deaths of over 6,000 people. Since there are no approved treatments or prevention modalities specifically targeted at Ebola Virus Disease (EVD), debate has focused on whether unproven interventions should be offered to Ebola patients outside of clinical trials. Those engaged in the debate have responded rapidly to a complex and evolving crisis, however, and this debate has not provided much opportunity for in-depth analysis. Additionally, the existing literature on access to unproven therapies has focused on contexts like HIV/AIDS and oncology, which are very different than the Ebola epidemic. In this paper, we examine the ethical issues surrounding access to unproven therapies in the context of the recent Ebola outbreak to yield new insights about this controversial and unsettled issue. We argue first that, in this context, the interests of patients in obtaining access to unproven therapies are not fully aligned with the interests of their providers and drug developers. Second, we focus on the resource constraints facing providers, funders, and patients and conclude that they often counsel against the use of unproven interventions against EVD.     

Scope of Semantic Activation and Innovative Thinking in College Students with ADHD

Adults with attention-deficit/hyperactivity disorder (ADHD) show high divergent thinking on standardized laboratory measures. This study assessed innovative thinking in adults with ADHD using a realistic task and investigated a possible cognitive mechanism for ADHD-related advantages in innovative thinking. College students with and without ADHD (n = 30 per group) completed a cell-phone feature invention task and word association task. Latent semantic analysis was used to measure semantic distance within cue-associate pairs on the word association task. Compared to non-ADHD peers, students with ADHD scored higher in originality, novelty, and flexibility on the cell phone task, and produced associates of lower semantic relatedness on the word association task. Tests of statistical mediation confirmed that the higher flexibility of the ADHD group was explained by semantic distance within cue-associate pairs on the word association task. Results support the possibility that ADHD is positively associated with specific aspects of innovative thinking, which may in part be attributable to a wide scope of semantic activation.     

Testing the theory of embodied cognition with subliminal words

In the current study, we tested the embodied cognition theory (ECT). The ECT postulates mandatory sensorimotor processing of words when accessing their meaning. We test that prediction by investigating whether invisible (i.e., subliminal) spatial words activate responses based on their long-term and short-term meaning. Masking of the words is used to prevent word visibility and intentional elaboration of the words’ semantic content. In this way, masking specifically isolates mandatory sensorimotor processing of words as predicted by the ECT. Do spatial subliminal words activate responses nonetheless? In Experiment 1, we demonstrate a spatial congruence effect of the invisible words if they precede visible target words. In Experiment 2, we show that masked words activate responses based on their long-term meaning. In Experiment 3, we demonstrate that masked words are also processed according to their short-term response meaning. We conclude that the ECT is supported by our findings and discuss implications of our results for embodied theories of semantic word processing and masked priming experiments.     

Trust and trustworthiness in a sequential bargaining game

We use a two‐person extensive form bargaining game to explore individuals' trusting and reciprocal behavior and how those relate to their scores on a trust survey. In keeping with prior research, we find that the ‘self‐interested’ outcome is rejected by a majority of individuals. People who score high on the trust survey are both trusting and are also trustworthy, in that they reciprocate others' trust. But people with low‐trust scores often exhibit trust but are not trustworthy. These ‘inconsistent trusters’ seem to be interested in exploiting the trust and trustworthiness of others in increasing their own payoff. Copyright © 2003 John Wiley & Sons, Ltd.     

Acting your avatar’s age: effects of virtual reality avatar embodiment on real life walking speed

ABSTRACT

When immersive virtual reality users employ digital self-representations, i.e., avatars, they may be subject to the Proteus effect. This effect describes changes in attitudes and behaviors in accordance with identity cues derived from the employed avatar’s appearance, which can persist after leaving virtual reality. Individual reactions to the experience can affect the strength of observed Proteus effects. Especially the experienced illusions of body ownership of avatars and of being in the virtual environment (spatial presence) have been discussed in this context. This study investigated a Proteus effect of avatar age on post-embodiment walking speed, with special focus on how body ownership and spatial presence moderated this effect. Participants who had previously embodied older avatars took significantly longer to walk a set distance than either young avatar or control group participants. This was only apparent during the first half of the walking phase, which may indicate fast decay rates of the effect after embodiment ended. The reported body ownership could not be shown to impact the strength of the Proteus effect. Participants reporting more pronounced spatial presence were subject to stronger Proteus effects, with only the two-thirds of the sample with higher spatial presence showing evidence of the effect.     

Personifying the Radical

This study examines relationships among individual dispositions, news framing of civil liberties restrictions, security concerns, and political tolerance. We theorize that news frames condition the effects of individual dispositions on security and tolerance attitudes. To explore these relationships, an online‐survey experiment was conducted with 650 respondents. This experiment presented alternative versions of news stories about domestic security policies following September 11, and the policies' implications for a fringe activist group. One factor was whether the activists targeted by the government advocated for a cause supported or opposed by the respondent; another factor was whether the story framed government actions against the activists at the individual or group level. Findings show that individual framing—as opposed to group framing—made participants less tolerant of radicals they opposed and more tolerant of radicals they supported. Similar effects were observed for political ideology. Implications of personification as a framing device are discussed.