Prediction of end-of-life fears in COPD – hoping for the best but preparing for the worst

Objective: The diagnosis of a life-threatening illness can trigger end-of-life fears. Early studies show that end-of-life fears play an important role in chronic obstructive pulmonary disease (COPD). However, predictors of these fears have not yet been identified. This study investigated the relevance of socio-demographic variables, illness severity, psychological distress and disease-specific anxieties as predictors of end-of-life fears in COPD.

Design: A total of 131 COPD patients participated at two time points. Regression and mediation analyses, as well as cross-lagged panel analyses were conducted.

Main outcome measures: The participants completed questionnaires assessing end-of-life fears (Multidimensional Orientation toward Dying and Death Inventory), psychological distress (Hospital Anxiety and Depression Scale), and disease-specific anxieties (COPD Anxiety Questionnaire). Pulmonary function and a 6-min walk test served as measures of illness severity.

Results: Illness severity was not predictive of end-of-life fears. However, gender and psychological distress explained incremental variance. When disease-specific anxieties were included as additional predictors, psychological distress was no longer significant. Cross-lagged panel analyses mostly supported these results. Moreover, disease-specific anxieties mediated the association between psychological distress and end-of-life fears.

Conclusion: Administration and intensity of end-of-life care (especially concerning end-of-life fears) in COPD patients should be based not only on illness severity, but rather on psychological distress and disease-specific anxieties.     

Automatic perceptual simulation of first language meanings during second language sentence processing in bilinguals

Research supports the claim that, when understanding language, people perform mental simulation using those parts of the brain which support sensation, action, and emotion. A major criticism of the findings quoted as evidence for embodied simulation, however, is that they could be a result of conscious image generation strategies. Here we exploit the well-known fact that bilinguals routinely and automatically activate both their languages during comprehension to test whether this automatic process is, in turn, modulated by embodied simulatory processes. Dutch participants heard English sentences containing interlingual homophones and implying specific distance relations, and had to subsequently respond to pictures of objects matching or mismatching this implied distance. Participants were significantly slower to reject critical items when their perceptual features matched said distance relationship. These results suggest that bilinguals not only activate task-irrelevant meanings of interlingual homophones, but also automatically simulate these meanings in a detailed perceptual fashion. Our study supports the claim that embodied simulation is not due to participants' conscious strategies, but is an automatic component of meaning construction.     

Caught in a bad romance: perfectionism, conflict, and depression in romantic relationships

According to the social disconnection model, perfectionistic concerns (i.e., harsh self-scrutiny, extreme concern over mistakes and others' evaluations, and excessive reactions to perceived failures) confer vulnerability to depressive symptoms indirectly through interpersonal problems. This study tested the social disconnection model in 226 heterosexual romantic dyads using a mixed longitudinal and experience sampling design. Perfectionistic concerns were measured using three partner-specific self-report questionnaires. Conflict was measured as a dyadic variable, incorporating reports from both partners. Depressive symptoms were measured using a self-report questionnaire. Perfectionistic concerns and depressive symptoms were measured at Day 1 and Day 28. Aggregated dyadic conflict was measured with daily online questionnaires from Days 2 to 15. Data were analyzed using structural equation modeling. There were four primary findings: (a) Dyadic conflict mediated the link between perfectionistic concerns and depressive symptoms, even when controlling for baseline depressive symptoms; (b) depressive symptoms were both an antecedent and a consequence of dyadic conflict; (c) perfectionistic concerns incrementally predicted dyadic conflict and depressive symptoms beyond neuroticism (i.e., a tendency to experience negative emotions) and other-oriented perfectionism (i.e., rigidly demanding perfection from one's partner); and (d) the relationships among variables did not differ based on gender. As the most rigorous test of the social disconnection model to date, this study provides strong support for this emerging model. Results also clarify the characterological and the interpersonal context within which depressive symptoms are likely to occur.     

Ole Doering (ed.), Chinese Scientists and Responsibility. Ethical Issues of Human Genetics in Chinese and International Contexts

Theoretical Medicine and Bioethics -