Applying evidence to support ethical decisions: Is the placebo really powerless?

Using placebos in day-to-day practice is an ethical problem. This paper summarises the available epidemiological evidence to support this difficult decision. Based on these data we propose to differentiate between placebo and “knowledge framing”. While the use of placebo should be confined to experimental settings in clinical trials, knowledge framing — which is only conceptually different from placebo — is a desired, expected and necessary component of any doctor-patient encounter. Examples from daily practice demonstrate both, the need to investigate the effects of knowledge framing and its impact on ethical, medical, economical and legal decisions. An earlier version of this paper was presented at an international conference, “Placebo: Its Action and Place in Health Research Today,” held in Warsaw, Poland on 12–13 April, 2003.     

One line decreases the visibility of a simultaneous identical distant second line

A top line decreased the visibility of a simultaneous, identical, distant bottom line. This context-produced decrease in visibility (DV) occurred when the bottom line was masked by flanking lines and hence was less visible than the top line. It continued when the top line was three times as far from the bottom line. It disappeared without the mask. There was a hint of an opposing context-produced increase in visibility (IV) when the lines were close together. The DV is not accounted for by numerous extant phenomena and theories. It means that the top line decreased the similarity in visibility between it and the bottom line, a contrast effect for visibility, rather than for a typical attribute. Contrast does not occur between two attributes that are perceptually equal. Therefore, the reason why two distant equally visible objects fail to result in a DV may be that their equal visibility precludes the occurrence of contrast. This DV-as-contrast theory is consistent with evidence that two groups (phenomenal wholes) are associated with both contrast and DVs, and thus also with evidence that one group is associated with both assimilation and IVs.     

A Short Measure of the Revised Reinforcement Sensitivity Theory – RSQ17

The need for a research and practical tool, such as a short, reliable, and valid personality assessment test, suggests researchers to create shortened versions of original instruments. Reinforcement sensitivity questionnaire (RSQ) was created in line with some basic premises of revised Reinforcement sensitivity theory, which proposes three motivational and emotional systems: Behavioral inhibition system (BIS), responsible for scanning environment for potential threats, Behavioral activation system (BAS), responsible for aproaching behavior, and the Fight/Flight/Freeze system (FFFS), responsible for behavior in the present threat. RSQ comprises five scales: BIS, BAS, Fight, Flight, and Freeze. The aim of this study was to develop a short version of RSQ, which would be beneficial to both research and practical purposes. Item response theory analyses were used for item selection. The study comprised two samples of participants, whereby Sample 1 (N = 837, 34.6% male, aged 18 – 82, M = 31.63, SD = 13.54) served as the derivation sample, while Sample 2 (818 participants, 43.6% male, 18?75 years, M = 29.65, SD = 12.52) served as validation sample. Factorial validity of the short RSQ was examined on both Sample 1 and Sample 2. Convergent and divergent validity of the short RSQ was examined using RST-PQ, Jackson-5, BIS/BAS scales, and Big Five Inventory. The results point to satisfactory internal consistency, factorial validity, and construct validity of the short RSQ, suggesting that it is an adequate measure for research settings or other contexts which require the use of short personality questionnaires.     

Characterizing Human Expertise Using Computational Metrics of Feature Diagnosticity in a Pattern Matching Task

Forensic evidence often involves an evaluation of whether two impressions were made by the same source, such as whether a fingerprint from a crime scene has detail in agreement with an impression taken from a suspect. Human experts currently outperform computer‐based comparison systems, but the strength of the evidence exemplified by the observed detail in agreement must be evaluated against the possibility that some other individual may have created the crime scene impression. Therefore, the strongest evidence comes from features in agreement that are also not shared with other impressions from other individuals. We characterize the nature of human expertise by applying two extant metrics to the images used in a fingerprint recognition task and use eye gaze data from experts to both tune and validate the models. The Attention via Information Maximization (AIM) model (Bruce & Tsotsos, 2009) quantifies the rarity of regions in the fingerprints to determine diagnosticity for purposes of excluding alternative sources. The CoVar model (Karklin & Lewicki, 2009) captures relationships between low‐level features, mimicking properties of the early visual system. Both models produced classification and generalization performance in the 75%–80% range when classifying where experts tend to look. A validation study using regions identified by the AIM model as diagnostic demonstrates that human experts perform better when given regions of high diagnosticity. The computational nature of the metrics may help guard against wrongful convictions, as well as provide a quantitative measure of the strength of evidence in casework.     

Prediction of end-of-life fears in COPD – hoping for the best but preparing for the worst

Objective: The diagnosis of a life-threatening illness can trigger end-of-life fears. Early studies show that end-of-life fears play an important role in chronic obstructive pulmonary disease (COPD). However, predictors of these fears have not yet been identified. This study investigated the relevance of socio-demographic variables, illness severity, psychological distress and disease-specific anxieties as predictors of end-of-life fears in COPD.

Design: A total of 131 COPD patients participated at two time points. Regression and mediation analyses, as well as cross-lagged panel analyses were conducted.

Main outcome measures: The participants completed questionnaires assessing end-of-life fears (Multidimensional Orientation toward Dying and Death Inventory), psychological distress (Hospital Anxiety and Depression Scale), and disease-specific anxieties (COPD Anxiety Questionnaire). Pulmonary function and a 6-min walk test served as measures of illness severity.

Results: Illness severity was not predictive of end-of-life fears. However, gender and psychological distress explained incremental variance. When disease-specific anxieties were included as additional predictors, psychological distress was no longer significant. Cross-lagged panel analyses mostly supported these results. Moreover, disease-specific anxieties mediated the association between psychological distress and end-of-life fears.

Conclusion: Administration and intensity of end-of-life care (especially concerning end-of-life fears) in COPD patients should be based not only on illness severity, but rather on psychological distress and disease-specific anxieties.     

Caught in a bad romance: perfectionism, conflict, and depression in romantic relationships

According to the social disconnection model, perfectionistic concerns (i.e., harsh self-scrutiny, extreme concern over mistakes and others' evaluations, and excessive reactions to perceived failures) confer vulnerability to depressive symptoms indirectly through interpersonal problems. This study tested the social disconnection model in 226 heterosexual romantic dyads using a mixed longitudinal and experience sampling design. Perfectionistic concerns were measured using three partner-specific self-report questionnaires. Conflict was measured as a dyadic variable, incorporating reports from both partners. Depressive symptoms were measured using a self-report questionnaire. Perfectionistic concerns and depressive symptoms were measured at Day 1 and Day 28. Aggregated dyadic conflict was measured with daily online questionnaires from Days 2 to 15. Data were analyzed using structural equation modeling. There were four primary findings: (a) Dyadic conflict mediated the link between perfectionistic concerns and depressive symptoms, even when controlling for baseline depressive symptoms; (b) depressive symptoms were both an antecedent and a consequence of dyadic conflict; (c) perfectionistic concerns incrementally predicted dyadic conflict and depressive symptoms beyond neuroticism (i.e., a tendency to experience negative emotions) and other-oriented perfectionism (i.e., rigidly demanding perfection from one's partner); and (d) the relationships among variables did not differ based on gender. As the most rigorous test of the social disconnection model to date, this study provides strong support for this emerging model. Results also clarify the characterological and the interpersonal context within which depressive symptoms are likely to occur.     

Radionuclear encephalo-angioscintigraphic studies in transitory disorders of brain circulation in childhood

Fifteen cases of transient cerebral ischaemia in children have been studied. Radionuclear encephaloangioscintigraphy (RNEAS) with Tc99 DTPA in combination with CT scanning, doppler sonography of extracranial head arteries and EEG were performed in all observed cases. For some children cerebral angiography was done. RNEAS study found out: stenosis of internal carotid artery or a. cerebri media in 5 cases; AV-malformations- 3; ischaemic area- 1, aneurysma- 1; increased blood permeability of the late static scintigraphy- 3. Positive correlation was established between the angioscintigraphic and sonographic findings in the cases with stenosis of internal carotid artery; between angioscintigraphic and CT results in the cases with ischaemia; between RNEAS and angiographic data in cases with AV-malformations, aneurysm and stenosis. In conclusion RNEAS could be considered as a useful, atraumatic screening method within the complex of laboratory examinations for vascular diseases in childhood.     

Workplace Bullying and Intention to Leave Among Schoolteachers in China: The Mediating Effect of Affective Commitment1

Workplace bullying includes behaviors such as harassing, offending, or socially excluding the target. This study examines whether the relationship between workplace bullying and intention to leave is mediated by affective commitment. Based on data from 142 schoolteachers in China, a partial least squares analysis revealed that affective commitment partially mediates the effect of bullying on intention to leave. Furthermore, the direct effect of bullying on intention to leave is stronger than the indirect effect. Theoretical and practical implications include that awareness needs to be raised about what constitutes bullying behavior and that more emphasis needs to be placed on preventing bullying in the workplace.     

Neurophysiologic markers of primary motor cortex for laryngeal muscles and premotor cortex in caudal opercular part of inferior frontal gyrus investigated in motor speech disorder: a navigated transcranial magnetic stimulation (TMS) study

Transcranial magnetic stimulation studies have so far reported the results of mapping the primary motor cortex (M1) for hand and tongue muscles in stuttering disorder. This study was designed to evaluate the feasibility of repetitive navigated transcranial magnetic stimulation (rTMS) for locating the M1 for laryngeal muscle and premotor cortical area in the caudal opercular part of inferior frontal gyrus, corresponding to Broca’s area in stuttering subjects by applying new methodology for mapping these motor speech areas. Sixteen stuttering and eleven control subjects underwent rTMS motor speech mapping using modified patterned rTMS. The subjects performed visual object naming task during rTMS applied to the (a) left M1 for laryngeal muscles for recording corticobulbar motor-evoked potentials (CoMEP) from cricothyroid muscle and (b) left premotor cortical area in the caudal opercular part of inferior frontal gyrus while recording long latency responses (LLR) from cricothyroid muscle. The latency of CoMEP in control subjects was 11.75 ± 2.07 ms and CoMEP amplitude was 294.47 ± 208.87 µV, and in stuttering subjects CoMEP latency was 12.13 ± 0.75 ms and 504.64 ± 487.93 µV CoMEP amplitude. The latency of LLR in control subjects was 52.8 ± 8.6 ms and 54.95 ± 4.86 in stuttering subjects. No significant differences were found in CoMEP latency, CoMEP amplitude, and LLR latency between stuttering and control-fluent speakers. These results indicate there are probably no differences in stuttering compared to controls in functional anatomy of the pathway used for transmission of information from premotor cortex to the M1 cortices for laryngeal muscle representation and from there via corticobulbar tract to laryngeal muscles.     

Psychological predictors for health-related quality of life and disability in persons with chronic obstructive pulmonary disease (COPD)

Objective: Individuals with chronic obstructive pulmonary disease (COPD) exhibit low physical and mental health-related quality of life (HRQL) and high susceptibility to disability. We investigated the influence of psychological factors on HRQL and disability in COPD individuals recruited from the general population. In line with Leventhal’s common sense model, we expected psychological factors to be associated with HRQL and disability even after controlling for medical status.

Methods: Individuals with COPD (n = 502; 59.7 years old; GOLD grades were I: 3%, II: 17%, III: 34%, IV: 46%) were assessed through an online survey administered via COPD patient organisations in Germany. Individuals filled in the Short Form Health Survey (SF-12), COPD Assessment Test, Patient Health Questionnaire (modules: GAD-2, PHQ-15, PHQ-9), Brief Illness Perception Questionnaire, a questionnaire that assesses causal illness attributions, and the internal illness-related locus of control scale of the ‘KKG questionnaire for the assessment of control beliefs about illness and health’. Multiple linear regressions were calculated.

Results: The investigated factors explained high variances (disability = 56%, physical HRQL = 28%, mental HRQL = 63%, p ≤ .001). Better mental health, more optimistic illness perceptions, attribution to psychological causes, and stronger internal locus of control were associated with lower disability and better HRQL. Comorbid somatic symptoms contributed to high disability and low quality of life.

Conclusion: Psychological factors, such as illness perception, attribution and internal locus of control, were associated with disability and HRQL. These factors should be considered when designing treatments for individuals with COPD, and adequate interventions should be provided to enhance illness understanding and self-management skills.