Early stopping of clinical trials: charting the ethical terrain

The decision to terminate a clinical trial earlier than planned is often described as ethically problematic, but it is rarely systematically analyzed as an ethical issue in its own right. This paper provides an overview of the main ethical considerations at stake in such decisions and of the main tensions between these considerations. Arguments about informed consent and the impact of early stopping on research and society are explored. We devote particular attention to a familiar conflict that arises with special urgency when early data suggest that the experimental treatment is superior. Should the trial be stopped so that participants in the control group will not be allocated a seemingly inferior treatment, or should it continue in pursuit of evidence conclusive enough to improve the care of future patients? We scrutinize three ways to address this problem. Rather than dissolving the tension, they represent different trade-offs between the respective welfare interests of subjects and future patients.     

Defining Information Security

Science and Engineering Ethics - This article proposes a new definition of information security, the ‘Appropriate Access’ definition. Apart from providing the basic criteria for a...     

Are Religions for Sale? Evidence from the Swedish Church Revolt Over Same‐Sex Marriage

Religious leaders sometimes condemn progressive social norms. This article revisits David Hume's hypothesis that secular states can “bribe” churches into adopting less strict religious doctrines. The hypothesis is difficult to test due to reverse causality: more liberal theologies may attract more political support in the first place. The empirical strategy used to circumvent this problem focuses on a theological conflict over same‐sex marriage within the Church of Sweden and takes advantage of political regulations that effectively make some parishes shareholders of the church's state‐protected property. The shares used for statistical identification are tied to property rights assigned more than 300 years ago, and they cannot be sold, traded, or amended by the individual parishes. The results show that priests in shareholding parishes are less likely to publicly oppose same‐sex marriage. The impact of political protection is stronger in parishes with more conservative members. The results are consistent with a model of clerical opportunism, in which income protection makes priests less likely to pander to the stricter followers.     

The Psychology of Leadership Destabilization: An Analysis of the 2016 U.S. Presidential Debates

When contesting for political office, leaders do not only seek to build their own following but also to engage in attacks to destabilize opponent leaders. However, research has yet to explore and explain the nature of attacks that seek to destabilize a leader's influence. Building on the identity leadership model which sees leadership as flowing from a leader's capacity to promote a sense of shared identity with followers, we argue that a leader can be destabilized if followers come to see the leader as defiling, devaluing, dividing, and destroying this shared sense of “us.” To explore these ideas, we analyzed the attack rhetoric used by Hillary Clinton and Donald Trump during the 2016 U.S. presidential debates to examine how they sought to subvert each other's leadership. Our analysis supports the proposed model and sheds light on the hitherto underexplored topic of leadership destabilization. Moreover, by helping us understand the ways in which principles of identity leadership can be weaponized to destabilize leadership, the analysis defines an important agenda for future research.     

Social Comparison and Consumer Behavior: When Feeling Richer or Poorer Than Others Is More Important Than Being So1

The present study investigates how households’ social comparisons of their economic situation affect purchase decisions. In structured telephone interviews, participants (n= 109) answered questions about purchases of durable goods and groceries. In line with the hypothesis, social comparisons had an effect on purchase decisions of durable goods when controlling for actual economic situation. Households that considered themselves to be worse off economically than others reported fewer purchases of durable goods, perceived the impact on their economy of their latest purchase to be greater, and planned purchases more carefully than did households that considered themselves better off economically than others. Also in line with the hypothesis, for purchases of groceries, households’ actual economic situation was more important than social comparisons.     

Superstars are not necessarily role models: Morality perceptions moderate the impact of competence perceptions on supervisor role modeling

There is a general assumption that we choose role models from the ranks of those who have demonstrated extraordinary competence. However, the person perception literature supports the expectation that morality may also matter, and that we may be most likely to role model competent individuals if we also believe that they have good moral character. To test this possibility, we conducted four studies of adults’ role modeling of workplace supervisors. Study 1 (N = 245) and Study 2 (N = 110) showed that workplace supervisors’ perceived competence was most strongly associated with role model perceptions when the supervisor was also seen as moral. Study 3 (N = 492) and 4 (N = 335) replicated these findings with pre‐registered experiments, and revealed indirect effects of supervisor attributes on role modeling through emulation. Results suggest that we choose organizational role models who have achieved success in ways that are in line with our moral values.     

Information Related to Prenatal Genetic Counseling: Interpretation by Adolescents, Effects on Risk Perception and Ethical Implications

Being raised in the genomic era may not only increase knowledge of available genetic testing but may also have an impact on how genetic information is perceived. However, little is known about how current adolescents react to the language commonly used by health care professionals providing prenatal counseling. In addition, as risk communication is related to numbers and figures, having different educational backgrounds may be associated with variability in risk perceptions. In order to investigate these issues, a previously developed questionnaire studying different ways of being told about hypothetical anomalies in a baby and corresponding risks (Abramsky and Fletcher Prenatal Diagnosis 22(13):1188-1194, 2002) was administered to high-school students in Sweden. A total of 344 questionnaires were completed by students belonging to a natural science or a social science program. The data show that teenage participants found technical jargon and words such as rare and abnormal more worrying than the presented comparison terms. Negative framing effects and perception differences related to numeric risk formats were also present. Additionally, participants' gender and educational program did not seem to have an effect on risk assessment. In addition to reporting the questionnaire results, we discuss the ethical implications of the data based on the norm of non-directiveness and make some recommendations for practice. In general, genetic counselors should be aware that the language used within clinical services can be influential on this group of upcoming counselees.     

Gender differences in teachers’ perceptions of students’ temperament,educational competence,and teachability

Background. Student's temperament plays a significant role in teacher's perception of the student's learning style, educational competence (EC), and teachability. Hence, temperament contributes to student's academic achievement and teacher's subjective ratings of school grades. However, little is known about the effect of gender and teacher's age on this association. Aims. We examined the effect of teacher's and student's gender and teacher's age on teacher‐perceived temperament, EC, and teachability, and whether there is significant same gender or different gender association between teachers and students in this relationship. Sample. The participants were population‐based sample of 3,212 Finnish adolescents (M= 15.1 years) and 221 subject teachers. Methods. Temperament was assessed with Temperament Assessment Battery for Children – Revised and Revised Dimensions of Temperament Survey batteries and EC with three subscales covering Cognitive ability, Motivation, and Maturity. Data were analyzed with multi‐level modelling. Results. Teachers perceived boys’ temperament and EC more negatively than girls’. However, the differences between boys and girls were not as large when perceived by male teachers, as they were when perceived by female teachers. Males perceived boys more positively and more capable in EC and teachability than females. They were also stricter regarding their perceptions of girls’ traits. With increasing age, males perceived boys’ inhibition as higher and mood lower. Generally, the older the teacher, the more mature he/she perceived the student. Conclusions. Teachers’ ratings varied systematically by their gender and age, and by students’ gender. This bias may have an effect on school grades and needs be taken into consideration in teacher education.