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131.
Reversible hippocampal lesions disrupt water maze performance during both recent and remote memory tests 总被引:6,自引:0,他引:6
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Conventional lesion methods have shown that damage to the rodent hippocampus can impair previously acquired spatial memory in tasks such as the water maze. In contrast, work with reversible lesion methods using a different spatial task has found remote memory to be spared. To determine whether the finding of spared remote spatial memory depends on the lesion method, we reversibly inactivated the hippocampus with lidocaine either immediately (0-DAY) or 1 mo (30-DAY) after training in a water maze. For both the 0-DAY and 30-DAY retention tests, rats that received lidocaine infusions exhibited impaired performance. In addition, when the 0-DAY group was retested 2 d later, (when the drug was no longer active), the effect was reversed. That is, rats that had previously received lidocaine performed as well as control rats did. These findings indicate that the rodent hippocampus is important for both recent and remote spatial memory, as assessed in the water maze. What determines whether remote spatial memory is preserved or impaired following disruption of hippocampal function appears to be the type of task used to assess spatial memory, not the method used to disrupt the hippocampus. 相似文献
132.
Nicola Bruno 《Cognitive processing》2006,7(1):22-22
Background
Perceiving the three-dimensional structure of an object often involves merging vision and haptics over extended periods of exploration. An interesting feature of this process is that as exploration progresses, new information may require changing how the two sensory signals are treated.Aims
We tested whether (1) bimodal interactions during extended observation can adjust to changes in the quality of unimodal sensory signals; and (2) there are specific temporal constraints on these adjustments.Methods
When viewing a three-dimensional Necker cube with one eye, participants experience illusory reversals even while they feel the cube with their hands. This surprising property makes the visual–haptic Necker cube an excellent model to investigate bimodal processes when previously consistent bimodal signals change in quality over time or begin to conflict. Our participants reported reversals while they viewed the cube and, at the same time, they either held it with two-finger grips, felt it with while their hands remained stationary, or actively explored it by moving one hand.Results
Consistent with a multisensory approach to three-dimensional form perception, touch had a clear effect on both the number and the duration of illusory percepts. Additionally, when observers alternated between stationary and moving periods during exploration, transitions from stationary to moving-hand haptics played a crucial role in inhibiting illusory reversals. A temporal analysis of the probability of first reversals occurring after different types of motor transition revealed a “vetoing window” initiating approximately 2 s after the transition and lasting at least another 1–2 s.Conclusions
These results suggest that intersensory merging is sensitive to changes in the quality of unimodal signals during exploration, and that adjustments caused by these changes are characterized by specific temporal dynamics.133.
Gray NS Brown AS MacCulloch MJ Smith J Snowden RJ 《Journal of abnormal psychology》2005,114(2):304-308
Pedophiles are motivated to disguise their thoughts and feelings about their sexual beliefs and attraction toward children. New developments using implicit measures of associations have been successful in accessing socially stigmatic beliefs, even in cases in which the participant is resistant to this disclosure. Using an implicit measure, the authors show that pedophiles have an association between children and sex, whereas nonpedophilic offenders have an association between adults and sex. The task can therefore identify a core cognitive abnormality that may underpin some pedophilic deviant sexual behavior. 相似文献
134.
Paul?KennedyEmail author Nicola?M.?Taylor Jane?Duff 《Journal of clinical psychology in medical settings》2005,12(1):93-98
Coping effectiveness training (CET), based on R. S. Lazarus and S. Folkmans (1984) theory of stress and coping, teaches appraisal and coping skills. It has been adapted for use with people with spinal cord injuries and the effect of this intervention on coping, anxiety and depression and self perception has been investigated. Using data from P. Kennedy, J. Duff, M. Evans, and A. Beedies (2003) study, the psychological characteristics of people who benefited from CET (no increase in depression and anxiety at the end of CET and 6 weeks after) were compared with those who did not benefit. Coping strategies were not predictive factors but differences in some self-perception items were found between the two groups. Age, gender, level, and type of injury were not shown to be predictive but time since injury was, suggesting that the effectiveness of a CET programme could be maximized by reducing the time between onset of injury and the start of CET. 相似文献
135.
An important question in the field of imitation is what information is used for movement reproduction. While it is argued that relative motion information is perceived and minimised, direct evidence is lacking. In this experiment relative motion was manipulated to convey a novel kicking action. Twenty-four adults were assigned to one of the three impoverished relative motion display groups showing only the TOE, FOOT or LEG. After practise with partial information, participants watched a full-body display and in a final condition performed the action with an additional context constraint (i.e., a ball). Movement kinematics were collected and difference scores between participants and the model were analysed. The groups did not differ in terms of knee-ankle coordination. For hip-knee, the TOE group performed more like the model than the FOOT and LEG group. When transferred to the full-body display, there were no significant improvements. End-point trajectory information can provide sufficient information to reproduce key characteristics of the movement form. 相似文献
136.
In a previous study, search for a notched-disk target abutting a square among complete-disk nontargets and squares was inefficient in 250-ms exposures, but relatively efficient in 100-ms exposures. This finding was interpreted as evidence that amodal completion proceeds through a mosaic and then a completion stage, with the latter preempting the former. We used the same target but changed its context: Nontargets were instead notched disks near squares. Task set was also different: Participants searched for a complete disk. Contrary to the prediction of the preemption model, search was efficient in the 100-ms condition and inefficient in the 250-ms condition. We propose that in both the present and the previous studies, the target was ambiguous, and task set and context affected how it was perceived. In both experiments, set effects were evident for 100-ms exposures; context effects were evident for 250-ms exposures. 相似文献
137.
Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe 总被引:3,自引:0,他引:3
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Middei S Geracitano R Caprioli A Mercuri N Ammassari-Teule M 《Learning & memory (Cold Spring Harbor, N.Y.)》2004,11(4):447-452
Mutations in the amyloid precursor protein (APP) gene inducing abnormal processing and deposition of beta-amyloid protein in the brain have been implicated in the pathogenesis of Alzheimer's disease (AD). Although Tg2576 mice with the Swedish mutation (hAPPswe) exhibit age-related Abeta-plaque formation in brain regions like the hippocampus, the amygdala, and the cortex, these mice show a rather specific deficit in hippocampal-dependent learning and memory tasks. In view of recent findings showing that neural systems subserving different forms of learning are not simply independent but that depressing or enhancing one system affects learning in another system, we decided to investigate fronto-striatal synaptic plasticity and related procedural learning in these mutants. Fronto-striatal long-term depression (LTD) induced by tetanic stimulation of the cortico-striatal input was similar in Tg2576 and wild-type control mice. Behavioral data, however, pointed to an enhancement of procedural learning in the mutants that showed robust motor-based learning in the cross maze and higher active avoidance scores. Thus, in this mouse model of AD, an intact striatal function associated with an impaired hippocampal function seems to provide neural conditions favorable to procedural learning. Our results suggest that focusing on preserved or enhanced forms of learning in AD patients might be of interest to describe the functional reorganization of the brain when one memory system is selectively compromised by neurological disease. 相似文献
138.
Hodges NJ Kerr T Starkes JL Weir PL Nananidou A 《Journal of experimental psychology. Applied》2004,10(4):219-237
In Studies 1 and 2, the authors evaluated deliberate practice theory through analyses of the relationship between practice and performance for 2 populations of athletes: triathletes and swimmers, respectively. In Study 3, the authors obtained evaluations of practice from athletes' diaries. Across athletes, length of time involved in fitness activities was not related to performance. For the triathletes, a significant percentage of variance in performance was captured by practice. This was not so for sprint events for the swimmers, in which gender was a significant predictor. In the diaries, physical activities were perceived as enjoyable. In contrast to the results obtained from questionnaires, enjoyment did not covary with an activity's relevance to improving performance. Although these findings highlight the importance of sport-specific practice, the authors question a domain-independent account of expertise based on deliberate practice. 相似文献
139.
Twenty children with spina bifida and twenty controls were assessed on a battery of visuospatial working memory tests. Children with spina bifida performed as well as the control group in the visuospatial test and in the forward and backward versions of the Corsi test, but were impaired in the 'House Visual Span.' This test, designed in our lab, provides specific information regarding visual ability to discriminate between pictorial targets and lures, and requires specific visual processing of stimuli. These results are discussed in terms of working memory models and are viewed as supporting the distinction between the visual and spatial components of working memory. 相似文献
140.
The authors tested the hypothesis that impaired behavioral performance during intoxication results partly from alcohol's deleterious effects on cognitive control. The impact of alcohol on perseverative behavior was examined with an n-back working memory task that included manipulations of task complexity and prepotency of inclinations to respond or withhold responding. Thirty-two social drinkers (16 men) participated in either an alcohol (.075g/100ml) or a no-alcohol condition. Alcohol increased perseveration of prepotent, task-inappropriate response patterns only under cognitively demanding (heavy memory load) conditions. This effect was evident for both commission errors (response persistence despite contingencies altered to require restraint) and omission errors (failure to respond when contingencies were revised to encourage action). Findings suggested that alcohol-induced perseveration arises from impairments in cognitive control. 相似文献