Biosecurity and Open-Source Biology: The Promise and Peril of Distributed Synthetic Biological Technologies

In this article, we raise ethical concerns about the potential misuse of open-source biology (OSB): biological research and development that progresses through an organisational model of radical openness, deskilling, and innovation. We compare this organisational structure to that of the open-source software model, and detail salient ethical implications of this model. We demonstrate that OSB, in virtue of its commitment to openness, may be resistant to governance attempts.     

Measuring work styles: Towards an understanding of the dynamic components of the theory of work adjustment

Work styles are an important yet largely unexplored component of the theory of work adjustment (TWA), describing a dynamic component of how individuals maintain and adjust fit with their work environment. The active work style (AWS) scale is the first attempt to develop a specific self-report measure of work styles suitable for longitudinal research. Results from three studies support Dawis and Lofquist's (1984) proposed four factor structure, but these factors are related through a second-order factor describing a person's generalised level of work activity and effort across time. The AWS scale demonstrated good evidence for reliability and validity, and strong measurement invariance across time signifying its suitability for longitudinal research. In line with expectations, overall work style was positively related to conscientiousness and work engagement yet unrelated to stress. When controlling for these variables, AWS was positively related to demands–abilities fit, but not needs–supplies fit. Limitations and possibilities for future research are also discussed.     

Emotional reactivity following surgery to the prefrontal cortex

We aimed to elicit emotion in patients with surgically circumscribed lesions of the prefrontal cortex (PFC) in order to elucidate the precise functional roles in emotion processing of the discrete subregions comprising the ventromedial PFC, including the medial PFC and orbitofrontal cortex (OFC). Three components of emotional reactivity were measured: subjective experience, behaviour, and physiological response. These included measures of self‐reported emotion, observer‐rated facial expression of emotion and measurements of heart rate and heart rate variability (HRV) during film viewing, and a measure of subjective emotional change since surgery. Patients with lesions to the ventromedial PFC demonstrated significant differences compared with controls in HRV during the film clips, suggesting a shift to greater dominance of sympathetic input. In contrast, patients with lesions restricted to the OFC showed significant differences in HRV suggesting reduced sympathetic input. They also showed less facial expression of emotion during positive film clips, and reported more subjective emotional change since surgery compared with controls. This human lesion study is important for refining theoretical models of emotion processing by the ventromedial PFC, which until now have primarily been based on anatomical connectivity, animal lesion, and human functional neuroimaging research. Such theories have implications for the treatment of a wide variety of emotional disorders.