Cardiovascular responses to acetylcholine: Effects of pentobarbital and autonomic blocking agents

The effect of acetylcholine chloride (ACh) on heart rate (HR) and blood pressure (BP) was studied in four dogs, awake and under anesthesia by means of pentobarbital sodium. In the awake dog, ACh caused a triphasic change in HR—a rise, fall and secondary rise. The BP showed an initial gradual fall followed by a secondary precipitous fall coinciding with the fall in HR, and then return to base line. Anesthesia accentuated the precipitous fall in HR due to ACh, and narrowed the pulse pressure during the initial fall in BP due to ACh. The effects of atropine sulphate, propranolol and d-tubacurarine on the above were studied, indicating the roles of the sympathetic and parasympathetic systems in mediating the HR and BP reactions to ACh in the awake state and under pentobarbital sodium anesthesia.     

Collateral Reports and Cross-Informant Agreement about Adult Psychopathology in 14 Societies

To advance international mental health assessment, instruments that have been internationally validated are needed. To this end, we analyzed ratings from 14 societies on the Adult Behavior Checklist (ABCL), a collateral-report form parallel to the Adult Self-Report (ASR; Achenbach and Rescorla 2003) for ages 18 to 59. Both the ABCL and the ASR assess problems, personal strengths, and adaptive functioning. For a sample of 8322 see note below collaterals, we found strong consistency across societies regarding which ABCL problem items tended to obtain relatively low, medium, or high ratings. Most societal effect sizes (ESs) for problem scale scores were small to medium (< 13.9 %), but the ES for the ABCL Personal Strengths scale was 25 %. For most of the same participants (N = 8,302), we analyzed cross-informant agreement between self-reports on the ASR and collateral reports on the ABCL. Cross-informant correlations for problem scale scores averaged .47, with considerable societal variation. Problem score means were higher on the ASR than the ABCL in every society, but the size of the difference varied across societies. Mean item ratings on the ABCL and ASR were highly correlated within every society (mean r = .92), but within-dyad item rating agreement varied widely in every society (mean r = .39). In all societies, non-corroboration of self-reported deviance and of collateral-reported deviance was common. Overall findings indicated considerable similarity but also some important differences in collateral-reported problems and adaptive functioning across 14 societies.     

The neural correlates of happiness: A review of PET and fMRI studies using autobiographical recall methods

Although very difficult to define, happiness is becoming a core concept within contemporary psychology and affective neuroscience. In the last two decades, the increased use of neuroimaging techniques has facilitated empirical study of the neural correlates of happiness. This area of research utilizes procedures that induce positive emotion and mood, and autobiographical recall is one of the most widely used and effective approaches. In this article, we review eight positron emission tomography and seven functional magnetic resonance imaging studies that have investigated happiness by using autobiographical recall to induce emotion. Regardless of the neuroimaging technique used, the studies conducted so far have shown that remembering happy events is primarily associated with the activation of many areas, including anterior cingulate cortex, prefrontal cortex, and insula. Importantly, these areas are also found to be connected with other basic emotions, such as sadness and anger. In the conclusion, we integrate these findings, discussing important limitations of the extant literature and suggesting new research directions.     

Engineering Ethics: Looking Back, Looking Forward

The eight pieces constituting this Meeting Report are summaries of presentations made during a panel session at the 2011 Association for Practical and Professional Ethics (APPE) annual meeting held between March 3rd and 6th in Cincinnati. Lisa Newton organized the session and served as chair. The panel of eight consisted both of pioneers in the field and more recent arrivals. It covered a range of topics from how the field has developed to where it should be going, from identification of issues needing further study to problems of training the next generation of engineers and engineering-ethics scholars.     

Reliability and plasticity of response inhibition and interference control

This study investigated the internal reliability, temporal stability and plasticity of commonly used measures of inhibition-related functions. Stop-signal, go/no-go, antisaccade, Simon, Eriksen flanker, Stroop and Continuous Performance tasks were administered twice to 23 healthy participants over a period of approximately 11 weeks in order to assess test–retest correlations, internal consistency (Cronbach’s alpha), and systematic between as well as within session performance changes. Most of the inhibition-related measures showed good test–retest reliabilities and internal consistencies, with the exception of the stop-signal reaction time measure, which showed poor reliability. Generally no systematic performance changes were observed across the two assessments with the exception of four variables of the Eriksen flanker, Simon and Stroop task which showed reduced variability of reaction time and an improvement in the response time for incongruent trials at second assessment. Predominantly stable performance within one test session was shown for most measures. Overall, these results are informative for studies with designs requiring temporally stable parameters e.g. genetic or longitudinal treatment studies.     

Lesbian, Gay, and Bisexual Identity Scale (LGBIS): construct validation, sensitivity analyses and other psychometric properties

According to Mohr and Fassinger (2006), identity is seen as both self-identification and collective identification with values, beliefs, traits or behaviours and attachments. Their Lesbian, Gay, and Bisexual (LGB) multidimensional identity model accounts for important variables regarding the constitution of identities. This model not only accesses numerous dimensions of the lives of LGB individuals, but is also based on a body of research that recognizes how LGB difficulties are caused by societal intolerance and marginalization (Mohr & Fassinger, 2000). The Lesbian, Gay, and Bisexual Identity Scale (LGBIS; Kendra & Mohr, 2008) constitutes an operationalization of this multidimensional model, and the aim of this article is to present its construct validity by analysing its factor structure using a sample of Portuguese lesbian, gay and bisexual participants. Results from exploratory and confirmatory factor analyses, as well as from factor invariance analysis across sub-samples are presented. In a general way, the factor structure obtained in this study follows the original proposal of Kendra and Mohr's (2008) LGBIS. Moreover, scale sensitivity analyses are presented in order to check for eventual differences in the factor structure and/or factor intercorrelations regarding participant gender and sexual orientation. These results are then discussed in the light of LGB identity models.