Assessment of pointer dog behavior

Studies of behavioral traits of the “Arkansas Line of nervous pointer dogs” are well documented (Murphreeet al., 1969). Demonstrations of drug effects on these traits, as measured on the standardized behavior test and expressed as “Morbidity Score,” have been disappointing, despite other evidence of effectiveness of drug treatments such as modification of operant performance (Murphreeet al. 1974c). A simple reproducible test with high interrater reliability is presented here. Subjects were nine nervous dogs that received placebo, pimozide, and chlordiazepoxide in a double-blind crossover design. Both drugs significantly attenuated “human avoidance,” a nervous trait. Placebo had no effect. The chlordiazepoxide effect was maximal on the first day of administration, returning to baseline three to four days after the last dose. The pimozide maximal effect was on day 4, with return to baseline six to nine days after the last dose. In addition to the aberrant behavior of the nervous pointer, hyperresponsiveness to dopaminergic stimulation and increased levels of L-DOPA in the cisternal spinal fluid were observed.     

Infant manual exploration of composite substrates

Everyday environments, even small regions within reach, vary dramatically in terms of material composition. Adapting one's manual behavior to such transitions can be considered to be an important element of skilled action. To investigate the origins of this ability, we presented 8-month-olds (n=24) and 10-month-olds (n=24) hard or soft objects on a composite tabletop substrate that was half rigid and half flexible. Results indicated infants explored the objects selectively and geared their manual behaviors, with or without an object in hand, to the particular substrate they contacted. More broadly, the study suggests that infant manual exploration is flexible even in the face of abrupt transitions in material structure. Such flexibility may support early attempts at problem solving and tool use.     

The influence of dibutyryl cyclic cmp on aggression in the mouse

Cytidine 3′,5′-cyclic monophosphate (cCMP) and its associated enzymes have recently been identified in a number of mammalian tissues. The analogy with other cyclic nucleotides leads to speculation that it may prove to be a second messenger for some neurotransmitters and/or hormones. In this study we examined the possibility that cCMP may modulate aggressive behaviour. When dibutyryl cCMP (250 μg and 2.5 mg/k SC) was administered to mice it proved to have a potent antiaggressive influence but had little effect on general activity. It was concluded that cCMP may prove to have an important metabolic function.     

Simulating Memory Impairment for Child Sexual Abuse

The current study investigated effects of simulated memory impairment on recall of child sexual abuse (CSA) information. A total of 144 adults were tested for memory of a written CSA scenario in which they role-played as the victim. There were four experimental groups and two testing sessions. During Session 1, participants read a CSA story and recalled it truthfully (Genuine group), omitted CSA information (Omission group), exaggerated CSA information (Commission group), or did not recall the story at all (No Rehearsal group). One week later, at Session 2, all participants were told to recount the scenario truthfully, and their memory was then tested using free recall and cued recall questions. The Session 1 manipulation affected memory accuracy during Session 2. Specifically, compared with the Genuine group's performance, the Omission, Commission, or No Rehearsal groups' performance was characterized by increased omission and commission errors and decreased reporting of correct details. Victim blame ratings (i.e., victim responsibility and provocativeness) and participant gender predicted increased error and decreased accuracy, whereas perpetrator blame ratings predicted decreased error and increased accuracy. Findings are discussed in relation to factors that may affect memory for CSA information. Copyright © 2015 John Wiley & Sons, Ltd.     

Adherence to antiretroviral medications in HIV: differences in data collected via self-report and electronic monitoring.

Controversy remains regarding the reliability of methods used to determine adherence to antiretroviral medication in HIV. In this study the authors compared adherence rates of 119 HIV-positive participants during a 6-month study, as estimated via electronic monitoring (EM) and self-report (SR). Adherence for both short (4-day) and long (4-week, or intervisit) periods was examined, as well as factors that underlie discrepancies between EM and SR. Results showed that intervisit EM estimates were consistently lower than those of SR. SR estimates based on shorter periods (4 days) were closer to those of EM. Higher discrepancies between EM and SR estimates were associated with lower cognitive functioning and externalized locus of control. These findings lend support for using both EM and SR methods; however, study design (e.g., length) and other factors (e.g., cognitive status, cost) should be considered.     

Evidence for the thalamic targets of the medial hypothalamic defensive system mediating emotional memory to predatory threats

Previous studies from our laboratory have documented that the medial hypothalamic defensive system is critically involved in processing actual and contextual predatory threats, and that the dorsal premammillary nucleus (PMd) represents the hypothalamic site most responsive to predatory threats. Anatomical findings suggest that the PMd is in a position to modulate memory processing through a projecting branch to specific thalamic nuclei, i.e., the nucleus reuniens (RE) and the ventral part of the anteromedial nucleus (AMv). In the present study, we investigated the role of these thalamic targets in both unconditioned (i.e., fear responses to predatory threat) and conditioned (i.e., contextual responses to predator-related cues) defensive behaviors. During cat exposure, all experimental groups exhibited intense defensive responses with the animals spending most of the time in the home cage displaying freezing behavior. However, during exposure to the environment previously associated with a cat, the animals with combined RE + AMv lesions, and to a lesser degree, animals with single AMv unilateral lesions, but not animals with single RE lesions, presented a reduction of contextual conditioned defensive responses. Overall, the present results provide clear evidence suggesting that the PMd’s main thalamic targets (i.e., the nucleus reuniens and the AMv) seem to be critically involved in the emotional memory processing related to predator cues.     

Role stress reexamined: An investigation of role stress predictors

R. L. Kahn, R. P. Wolfe, R. P. Quinn, J. D. Snock, and R. A. Rosenthal (1964, Organizational Stress: Studies in Role Conflict and Ambiguity, New York: Wiley) distinguished three different types of predictor of role stress; personal, interpersonal, and organizational. Based on a sample of young professional engineers this investigation studied the relationship betwen these three types of predictor and four forms of role stress (role conflict, role ambiguity, quantitative role overload, qualitative role underload). The relationship was studied both within each predictor set and between each predictor set. Employing bivariate and multiple regression analyses, variables were identified within each predictor set which were significantly predictive of role stress. In addition, comparison was made between the sets of predictor variables selected and between each of the four role stresses that were studied. The results support the relevance of personal, interpersonal, and organizational predictors to role stress, as well as suggesting that role stress researchers should pay more attention to differentiating between varying forms of role Stress.