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61.
Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system 总被引:5,自引:0,他引:5
Da Cunha C Wietzikoski S Wietzikoski EC Miyoshi E Ferro MM Anselmo-Franci JA Canteras NS 《Neurobiology of learning and memory》2003,79(3):236-242
The aim of the present study was to test if the nigrostriatal pathway is an essential component for a water maze cued task learning and if it works independently of the hippocampal memory system. This hypothesis was tested using an animal model of Parkinson's disease in which male Wistar rats were lesioned in the substantia nigra pars compacta (SNc) by the intranigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), thus causing a partial depletion of striatal dopamine. SNc-lesioned and sham-operated animals were implanted bilaterally with guide cannulae above the dorsal hippocampus in order to be tested after the administration of 0.4 microl 2% lidocaine or saline into this structure. The animals were tested in a spatial or in a cued version of the water maze, memory tasks previously reported to model hippocampal-dependent spatial/relational and striatal-dependent S-R learning, respectively. Hippocampal inactivation, but not SNc lesion, impaired learning and memory in the spatial version of the water maze. An opposite situation was observed with the cued version. No significant interaction was observed between the SNc lesion and hippocampal inactivation conditions affecting scores in the spatial or in the cued version of the water maze. These results suggest that the nigrostriatal pathway is an essential part of the memory system that processes S-R learning and that it works independently of the hippocampal memory system that processes spatial/relational memories. 相似文献
62.
63.
Schrödinger logics are logical systems in which the principle of identity is not true in general. The intuitive motivation for these logics is both Erwin Schrödinger's thesis (which has been advanced by other authors) that identity lacks sense for elementary particles of modern physics, and the way which physicists deal with this concept; normally, they understandidentity as meaningindistinguishability (agreemment with respect to attributes). Observing that these concepts are equivalent in classical logic and mathematics, which underly the usual physical theories, we present a higher-order logical system in which these concepts are systematically separated. A classical semantics for the system is presented and some philosophical related questions are mentioned. One of the main characteristics of our system is that Leibniz' Principle of the Identity of Indiscernibles cannot be derived. This fact is in accordance with some authors who maintain that quantum mechanics violates this principle. Furthermore, our system may be viewed as a way of making sense some of Schrödinger's logical intuitions about the nature of elementary particles.The authors very much would like to thank the anonymous referee for his quite interesting suggestions, which contributed significantly to improve the paper.Presented byJan Zygmunt; 相似文献
64.
This essay considers the current impact and evaluation of Far Eastern psychic healing typified by the psychic surgery of the Philippine Islands. On the basis of a literature survey as well as interviews with persons who had visited the healers and received psychic surgery, an analysis of the spiritual dynamics and physical effects is reported. An attempt is made to balance the positive reports of those who were healed with the more objective and/or skeptical reports of religious and scientific leaders. Cultural, psychological, medical, and magical aspects are considered. An expansion of philosophic outlook coupled with a search for new tools of investigation is suggested.This paper is the result of an exploration of various healing modalities by the authors. 相似文献
65.
H. Newton Malony 《Pastoral Psychology》1993,41(4):237-246
This essay discusses the importance of assessing the religious condition of persons in pastoral care and counseling. Undertaking such assessments via the use of explicit theological terms assures a unique role for pastoral counselors in the helping process and provides a model that avoids overdependence on psychology or psychiatry. Utilizing a method proposed by Paul Pruyser, the development of a psychometrically sound interview and inventory is described. These measures, based on eight dimensions of the Christian tradition, have been found to relate positively to mental health and personality strength. The importance of using such assessments of functional theology in helping persons grow in spiritual living and effective functioning is described.Paper delivered at the 4th International Congress on Pastoral Care and Counseling, Noordwijkerhout, The Netherlands, August 3–10, 1991. 相似文献
66.
Newton Garver 《Topoi》1991,10(2):187-198
Conclusion In previous essays (1973, 1975, 1977) I have praised Derrida's contributions to philosophical dialogue and also insisted on their limitations. The considerations raised in this present essay do not lead me to a position that is less ambivalent.Philosophy is a particular language-game. Like any other, it has its constitutive rules; or, perhaps better: its practice has certain distinctive features by means of which we recognize philosophizing and distinguish it from other linguistic activities. None of this can be set down in the form of necessary and sufficient conditions, and there always will be large areas of controversy about the paradigms themselves. Nonetheless there are philosophers, and they generally acknowledge Plato, Aristotle, Leibniz, Hume, and even some of their colleagues as also being philosophers. This acknowledgement holds even where there is philosophical disagreement - as must inevitably be the case, in view of the dialogical character of philosophical discourse.Derrida occasionally enters into the dialogue, as do many others - poets, novelists, critics, diplomats, attorneys, cooks, barbers, and babysitters. These occasional contributions to philosophical dialogue differ in focus, in style, and in lack of self-referentiality from the works which constitute the main corpus of philosophy. Some might wish to say, as if the matter were paradoxical, that such contributions are both philosophical and not philosophical, or that they are neither philosophy nor not-philosophy. That might be as good a thing to say as anything. The practice of philosophy is complex and has many levels. Those who are acknowledged as its finest practitioners have a focus, a style, and a respect for where questions begin and end. Derrida does not share these qualities, and does not care to share them. That is no reason to ignore his work, but it is sufficient to explain why philosophers do not recognize it as a contribution to the central corpus of philosophy. 相似文献
67.
Effect of person. 1966 总被引:1,自引:0,他引:1
68.
Effectiveness of ministers is difficult to measure. Ideally, the goal would be to find out if they have been helpful in reconciling people to God and to each other. However, these criteria can only be assessed indirectly. This essay proposes a model of effectiveness and reviews several studies designed to assess one or more of its facets. Although results are only somewhat conclusive, the methods are promising and future research on this foundation is indicated. 相似文献
69.
In order to develop an account of scientific rationality, two problems need to be addressed: (i) how to make sense of episodes
of theory change in science where the lack of a cumulative development is found, and (ii) how to accommodate cases of scientific
change where lack of consistency is involved. In this paper, we sketch a model of scientific rationality that accommodates
both problems. We first provide a framework within which it is possible to make sense of scientific revolutions, but which
still preserves some (partial) relations between old and new theories. The existence of these relations help to explain why
the break between different theories is never too radical as to make it impossible for one to interpret the process in perfectly
rational terms. We then defend the view that if scientific theories are taken to be quasi-true, and if the underlying logic
is paraconsistent, it’s perfectly rational for scientists and mathematicians to entertain inconsistent theories without triviality.
As a result, as opposed to what is demanded by traditional approaches to rationality, it’s not irrational to entertain inconsistent
theories. Finally, we conclude the paper by arguing that the view advanced here provides a new way of thinking about the foundations
of science. In particular, it extends in important respects both coherentist and foundationalist approaches to knowledge,
without the troubles that plague traditional views of scientific rationality. 相似文献
70.
A model of union participation: the impact of perceived union support, union instrumentality, and union loyalty 总被引:1,自引:0,他引:1
Perceived union support and union instrumentality have been shown to uniquely predict union loyalty. This study was the first to explicitly examine the relation between perceived union support and union instrumentality. Surveys were completed by 273 union members and 29 union stewards. A comparison of 2 models, 1 based on organizational support theory and 1 based on union participation theories, found that the model based on organizational support theory, in which union instrumentality was an antecedent to perceived union support and led to union loyalty and subsequently union participation, best fit the data. The model based on union participation theories, in which perceived union support was an antecedent of union instrumentality and led to union loyalty and subsequently union participation, was not supported. Union instrumentality was related to union commitment, but the relation was completely mediated by perceived union support. 相似文献