Semantic interference and associative facilitation from words presented in rapid serial visual presentation

Semantic interference in picture naming is readily obtained when categorically related distractor words are displayed with picture targets; however, this is not typically the case when both primes and targets are words. Researchers have argued that to obtain semantic interference for word primes and targets, the prime must be shown for a sufficient duration, prime processing must be made difficult, and participants must attend to the primes. In this article, we used a novel procedure for prime presentation to investigate semantic interference in word naming. Primes were presented as the last word of a rapid serial visual presentation stream, with the target following 600-1,200 msec later. Semantic interference was observed for categorically related targets, whereas facilitation was found for associatively related targets.     

5HT antagonists attenuate MK801-impaired radial arm maze performance in rats

Glutamatergic hypofunction occurs in Alzheimer's disease (AD). MK801, a noncompetitive blocker of glutamate N-methyl-D-aspartate receptors, was used to disrupt the cognitive performance of rats trained on a delayed nonmatching to sample radial maze task. Drugs which act by blocking serotonin (5-HT) receptors were evaluated for their ability to reduce the cognitive impairment produced by MK801. Specifically, WAY-100635, a selective 5-HT1A receptor antagonist, buspirone, a 5-HT1A partial agonist, ritanserin, a 5-HT2 antagonist, and ondansetron, a 5-HT3 antagonist, were assessed. In addition, the muscarinic agonist arecoline was evaluated for its potential cognitive benefit in this model. It was found that WAY-100635 significantly reduced the cognitive impairment induced by MK801. Treatment with single doses of ritanserin, ondansetron, or arecoline in combination with MK801 did not result in a cognitive impairment, indicating that these drugs attenuated the MK801 impairment. The combination of buspirone and MK801 resulted in an inability of the animals to complete the task. These results suggest that interactions between 5-HT and glutamate may mediate the beneficial effects of reducing cognitive impairment and that 5-HT antagonists, especially selective 5-HT1A antagonists, may be useful in treating AD. Further, it is indicated that the MK801 model of cognitive impairment may add to the armamentarium of tools available to predict treatment efficacy in AD.     

Deconstructing the Time-Out: What Do Mothers Understand About a Common Disciplinary Procedure?

Time-out (TO) is one of the most common and effective disciplinary tactics used to address problem behavior; however, parents rate TO as one of the least useful behavior modification techniques. This may be due to a discrepancy between empirically supported TO procedures and how mothers are actually conducting TO. Fifty-five mothers were asked to define TO, provide information on how they conduct TO, and identify errors in TO procedures. Results indicate that maternal knowledge and implementation of TO differs considerably from the empirical ideal, potentially impacting the utility and frequency of TO usage in the home to address child problem behaviors.     

Acceptance and Commitment Therapy for Posttraumatic Stress Disorder in Early Psychosis: A Case Series

Persons with psychosis often report high levels of posttraumatic stress disorder (PTSD) symptoms, which render them more vulnerable to relapse, symptom exacerbation, and reduced well-being. However, less is known about how to adequately accommodate the needs of persons recovering from a first episode of psychosis, presenting with PTSD. Further, the existing evidence-based interventions for PTSD seem less equipped to deal with serious mental disorder and comorbid conditions. This study aimed to assess the efficacy, acceptability, and safety of Acceptance and Commitment Therapy (ACT) for persons suffering from PTSD with comorbid trauma and psychosis. Three consecutively referred participants meeting ICD-10 criteria for PTSD and a first-episode nonaffective psychotic disorder were treated in an outpatient service within a case-series analysis. A manual-guided ACT intervention of 12 sessions showed clinically relevant improvement on self-report measures of PTSD symptoms and emotional distress. These initial findings are promising and appear to justify a more controlled evaluation of this brief intervention.     

Measurement as transcendental–empirical <Emphasis Type="Italic">écart</Emphasis>: Merleau-Ponty on deep temporality

Merleau-Ponty’s radical reflection conceptualizes the transcendental and the empirical as intertwined, emerging only via an écart. I advance this concept of transcendental empirical écart by studying the problem of measurement in science, in both general and quantum mechanical contexts. Section one analyses scientific problems of measurement, focusing on issues of temporality, to show how measurement entails a transcendental that diverges with the empirical. Section two briefly interprets this result via Merleau-Ponty’s concept of depth, to indicate how measurement reveals a temporality that is not an already given ground that would guarantee the transcendental in advance: temporality is instead ‘deep,’ itself engendering a divergence of transcendental and empirical operations that first allows for measurement and sense.     

Whether, when, and why Skinner published on biological participation in behavior

This paper brings some data to bear on the criticisms, claims, and arguments that Skinner (a) denied or dismissed biological participation in behavior, (b) addressed it only late in his career or more often later than earlier, or (c) addressed it only because of the overwhelming evidence for it or the criticisms that he had overlooked it. For this, we coded Skinner's every primary-source publication for three content categories (i.e., genetics, physiology, and evolution) and for the extent to which he addressed them (i.e., in publication titles, substantively, or in passing). Our findings are that Skinner addressed biological participation in over a third of his publications throughout his career, albeit more often later than earlier. The latter, however, is accounted for by an increase in his base rate of publication and in general conditions and specific events in his career, psychology, and science. The discussion addresses our research methods; the reasons for and refutations of the criticisms, claims, and arguments; and their sources.     

Susceptibility to memory distortion: how do we decide it has occurred?

When given suggestive information, some people can be led to believe that they had experiences that they did not actually have. For example, they may come to believe falsely that they got sick eating particular foods as children, and as a result of that belief they may avoid the foods. But how do we know that someone has developed a false belief or memory in this research? The criteria we choose when classifying whether someone has fallen for the suggestion are somewhat arbitrary. We reanalyze our prior data, using different criteria for deciding that a person fell for the suggestion (called a "believer") or did not (called a "non-believer"). Changing criteria obviously affects the percentage of people who are called susceptible and could conceivably affect the conclusions reached about that group. Comparisons between false memories and true memories could differ, too, depending on how memories are defined.     

Electrophysiological analysis of error monitoring in schizophrenia

In this study, the authors sought to determine whether abnormalities exhibited by schizophrenia patients in event-related potentials associated with self-monitoring--the error-related negativity (ERN) and the correct response negativity (CRN)--persist under conditions that maximize ERN amplitude and to examine relationships between the ERN and behavior in schizophrenia. Participants performed a flanker task under 2 contingencies: one encouraging accuracy and another emphasizing speed. Compared with healthy participants, in schizophrenia patients the ERN was reduced in the accuracy condition, and the CRN was enhanced in the speed condition. The amplitude of a later ERP component, the error positivity, did not differ between groups in either task condition. Reduced self-correction and increased accuracy following errors were associated with larger ERNs in both groups. Thus, ERN generation appears to be abnormal in schizophrenia patients even under conditions demonstrated to maximize ERN amplitude; however, functional characteristics of the ERN appear to be intact.