Do behavioral responses mediate or moderate the relation between cardiovascular reactivity to stress and parental history of hypertension?

To examine whether differences in behavioral responses to stress mediated or moderated the relation between cardiovascular response to stress and parental history of hypertension, 64 healthy undergraduates-16 men with hypertensive parents (PH+), 16 men without hypertensive parents (PH-), 16 PH+ women, and 16 PH- women-participated in a mental arithmetic task, mirror tracing task, and 2 interpersonal role plays. PH+ participants exhibited higher resting heart rates than PH- participants and higher resting systolic blood pressures (SBPs) than PH- women. PH+ participants exhibited greater SBP responses to tasks and engaged in more negative verbal and nonverbal behavior across tasks than PH- counterparts. Differences in behavioral responding neither mediated nor moderated the observed relation between parental history status and SBP response to stress.     

Stress and Cytokine Effects on Learning: What Does Sex Have to Do With It?

Many studies have alluded to sexually dimorphic changes in behavior following stress. Although many have suggested that these changes are a function of stress-induced changes in learning and memory, there are questions regarding whether performance in those learning and memory tasks are influenced by stress-induced changes in drive more than in actual learning and memory processes. We used the classically conditioned eyeblink response (CCER) to determine whether slowed learning following stress in females can be explained by changes in unconditional response (UR) amplitude, a sign of a stress-induced shift in sensory reactivity. In addition, we had a second treatment group injected with the pro-inflammatory cytokine IL-1beta to serve as an interoceptive stress condition, a physiological stressor with minimal stimulation to the animal. Replicating the work by Shors and colleagues, we found that stressed female rats had slower acquisition of the conditioned response (CR), but we also found that an IL-1beta injection leads to a slowing of CR acquisition. However, in both cases, UR amplitude was lower in the treatment groups. We followed up these results by testing sensory reactivity through the acoustic startle response (ASR), where the magnitude of the ASR was marginally, but nonsignificantly, reduced by the same dose regimen of IL-1beta. Together, these experiments suggest that tailshock stress and immune signaling (IL-1beta) reduce sensory reactivity and the saliency of the stimuli used in the CCER, leading to slower learning in female rats.     

Presurgical MMPI-2 Cluster Profiles Predict 1-Year Low-Back Surgery Outcomes

The primary purpose of this study was to examine whether empirically derived cluster profiles based on scores from the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) predicted outcomes of surgery at 1 year for patients with low-back pain. On the basis of hierarchical cluster analysis of presurgery MMPI-2 scores for 60 patients, three interpretable and significant subgroups were formed. These consisted of a pathological/neurotic type, a double V-code type, and a normal type. The patents in the normal type were significantly more likely to report beneficial outcomes of surgery in terms of disability and pain than those in the other 2 types. These findings extend previous research and suggest (1) low-back surgery candidates are heterogeneous in their psychological profiles, and (2) MMPI-2 profiles are predictive of low-back surgery outcome. Future research should focus on identifying physiological substrates for these distinct profiles and investigating the effectiveness of presurgical psychological interventions based on profile type.     

Refining Measurement of Career Indecision Types: A Validity Study

The authors conducted this study to address some of the limitations in previous indecision typology research and to provide validity evidence for the indecision types that were derived. The participants were 566 first‐semester, undecided students enrolled in a career exploration course. Career indecision, personality, and ability measures were used to derive career indecision types through cluster analysis. Four distinct career indecision types were identified. Subsequently, the effect of indecision type on response to a career exploration course was examined. Level of career indecision, the criterion variable, was not differentially affected by indecision type. Implications of the findings for career counseling are discussed.     

Thomas P. Kasulis,Intimacy or Integrity: Philosophy and Cultural Difference

International Journal for Philosophy of Religion -     

Letter legibility and visual word recognition

Word recognition performance varies systematically as a function of where the eyes fixate in the word. Performance is maximal with the eye slightly left of the center of the word and decreases drastically to both sides of thisoptimal viewing position. While manipulations of lexical factors have only marginal effects on this phenomenon, previous studies have pointed to a relation between the viewing position effect (VPE) and letter legibility: When letter legibility drops, the VPE becomes more exaggerated. To further investigate this phenomenon, we improved letter legibility by magnifying letter size in a way that was proportional to the distance from fixation (e.g., TABLE). Contrary to what would be expected if the VPE were due to limits of acuity, improving the legibility of letters has only a restricted influence on performance. In particular, for long words, a strong VPE remains even when letter legibility is equalized across eccentricities. The failure to neutralize the VPE is interpreted in terms of perceptual learning: Since normally, because of acuity limitations, the only information available in parafoveal vision concerns low-resolution features of letters; even when magnification provides better information, readers are unable to make use of it.     

Issues surrounding the cognitive neuroscience of obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) has been studied extensively in recent years, with increased emphasis on understanding OCD’s biological substrates. There has been significant progress in documenting abnormal brain function in OCD patients, particularly in the orbitofrontal cortex, basal ganglia, and thalamus. Similar progress has broadened our understanding of the cognitive and behavioral manifestations of the disorder, including deficits in set shifting, hyperattention, and visuospatial construction abilities. Unfortunately, these results have not been replicated consistently. This report comprises a review of previous attempts to characterize the neurobiology and neuropsychology of OCD, and a discussion of several factors in OCD research that can help to explain previous inconsistencies.