Getting the ethics right regarding research in the emergency setting: lessons from the PolyHeme study

Research in emergency settings (RES) has become a major public issue with urgent policy implications. Significant attention has focused recently on RES in response to the trial of PolyHeme, a synthetic blood substitute, in trauma victims in hemorrhagic shock. Unfortunately, the discussion of the PolyHeme trial in the popular and scholarly press leaves important questions unanswered. This paper articulates three important lessons from the PolyHeme trial that have significant policy implications. First, the RES regulations should be re-visited, particularly the requirement that existing treatments be unproven or unsatisfactory in order for research to be acceptable without consent. Second, further conceptual and empirical scholarship is needed to accomplish the goal of effectively involving communities. Third, a more subtle analysis is needed regarding how to balance the needs of maintaining public trust and protecting confidential trade information in the context of RES.     

Reasons-Responsive Compatibilism and the Consequences of Belief

John Martin Fischer and Mark Ravizza offer a theory of moral responsibility which makes responsibility dependent upon the way in which moral agents view themselves. According to the theory, agents are responsible for their actions only if they think of themselves as apt candidates for praise and blame; if they come to believe they are not apt candidates for praise and blame, they are ipso facto not morally responsible. In what follows, I show that Fischer and Ravizza’s account of responsibility for consequences is inconsistent with this subjective element of their theory, and that the subjective element may be retained only if they are willing to implausibly restrict their account of responsibility for consequences. I end by discussing the broad significance of the failure of the subjective element for their overall approach to moral responsibility.     

Counterfactual thinking facilitates behavioral intentions

People often ponder what might have been, and these counterfactual inferences have been linked to behavior regulation. Counterfactuals may enhance performance by either a content-specific pathway (via shift in behavioral intentions) and/or a content-neutral pathway (via mindsets or motivation). Three experiments provided new specification of the content-specific pathway. A sequential priming paradigm revealed that counterfactual judgments facilitated RTs to complete behavioral intention judgments relative to control judgments and to a no-judgment baseline (Experiment 1). This facilitation effect was found only for intention judgments that matched the information content of the counterfactual (Experiment 2) and only for intention judgments as opposed to a different judgment that nevertheless focused on the same information content (Experiment 3). These findings clarify the content-specific pathway by which counterfactuals influence behavior.     

The development of a general associative learning account of skill acquisition in a relative arrival-time judgment task

Current theory assumes that individuals only use information from the immediate environment to perform relative arrival-time judgment tasks. This article presents a theoretical analysis of the memory requirements of this task. The authors present an analysis of the inputs to the memory system and the processes that map those inputs onto outputs. The analysis generates a set of predictions regarding the specificity of transfer and the role of context during learning. In 3 experiments, participants decided whether pairs of aircraft would violate a minimum separation standard or pass each other safely. Participants were presented with pairs of aircraft in which properties of the pair varied along 3 structural and 3 surface dimensions. Contexts were defined by the co-occurrence of specific values along stimulus dimensions and the use of a neutral label. The results suggest that transfer was limited by the dimensions that were varied in training and the context in which those dimensions were varied. The discussion focuses on the problems that complex tasks like relative judgment pose for associative learning mechanisms and the development of precise models of cognition.     

Resolving Nationalist Conflicts: Promoting Overlapping Identities and Pooling Sovereignty—The 1998 Northern Irish Peace Agreement

Nationalist and ethnic conflicts are a continuing source of tension in the post–Cold War period. The underlying factors affecting such conflicts are threat perception, ethnic security dilemmas, and lack of trust between nationalist/ethnic groups. The challenge is to find solutions to these conflicts. International institutions can establish trust and reduce the ethnic security dilemma by providing multiple forums of representation, promoting overlapping identities, and pooling sovereignty. Pooling sovereignty across a number of international representative bodies leads to increased access to governmental policymaking, with each party having a stake in government, and leads to a reduction in political tension and conflict. Thus, international parliamentary institutions may provide a solution to these conflicts. The British-Irish Peace Agreement (Good Friday Agreement) of 1998 is examined as an illustration of this argument.     

Prenatal testosterone treatment potentiates the aggression‐inhibiting effect of the neurosteroid dehydroepiandrosterone in female mice

The neurosteroid dehydroepiandrosterone (DHEA) is a powerful inhibitor of aggression in murine models when given for 15 days and potentially may be useful in the management of inappropriate human aggression. Although the biosynthesis and metabolism of DHEA have been described, little is known about the potential effect of the steroidal environment during sexual differentiation on the subsequent response to DHEA. Whether prenatal androgen exposure influences the subsequent response to DHEA was assessed by comparing the effect of DHEA (80 μg/d) on aggression in female offspring where dams were treated with 1, 10, or 100 μg of testosterone (T) on days 15 to 18 of gestation (Experiment I) or that developed in different uterine positions (Experiment II). The results showed that DHEA decreased attack behavior in general and that the 100‐μg prenatal T treatments enhanced the antiaggressive effect of this neurosteroid. Neither the lower doses of exogenously administered T nor the uterine position led to an enhanced response to DHEA. In addition, whether DHEA produced changes in social and nonsocial activities was examined. In the 100‐μg T females, DHEA increased the duration of the former and decreased the frequency and duration of the latter, indicating that it was not a general decrement in behavioral expression that mediated the enhanced response to the antiaggressive effect of DHEA. In the second experiment, DHEA treatment led to increased frequencies of social nonaggressive and nonsocial activities. However, the uterine positions × treatment interactions were not significant, demonstrating that contiguity to male fetuses did not differentially affect the response to DHEA. Aggr. Behav. 27:130–138, 2001. © 2001 Wiley‐Liss, Inc.     

Gender differences in social support among older adults

The purpose of this study was to determine whether exposure to life stress can help explain gender differences in the use of social support. Findings from a longitudinal study suggest that as the number of stressful life events increase, elderly men and women are equally likely to become more involved in their social network, while gender differences emerge only in response to chronic financial strain. Further analysis indicates that elderly women are more likely than elderly men to report that the support they received increased their feelings of personal control.