Narcolepsy: pathophysiology and neuropsychological changes

Narcolepsy is now recognized as a distinctive disorder with specific pathophysiology and neurochemical abnormalities. Findings on the role of the neuropeptide hypocretin are opening new avenues of research and new strategies for therapy. Recently, neuropsychological and electrophysiological studies have provided evidence for reduced memory performance on standard memory tests in addition to subjective complaints of forgetfulness which may be related to changes in attentional processing. Further studies are, however, necessary to clarify the neuropsychological profile in narcolepsy. This review focuses on the recent advances in understanding narcolepsy.     

Aktuelle Entwicklungen der psychodynamischen Psychotherapieforschung

The effectiveness of psychodynamic psychotherapy has been a “hot topic” in scientific and healthcare related debates in recent years. During this time a significant amount of new evidence supporting the effectiveness of psychodynamic psychotherapy has been published. The paper provides an overview on current psychodynamic psychotherapy research, with a focus on meta-analytic findings and randomized effectiveness trials. The results in the literature show robust evidence for the effectiveness of psychodynamic therapies for a wide range of psychiatric disorders. The methodological quality of current studies is good and comparative trials with other forms of psychotherapy yield mostly equivalent results. However, further studies are needed with regard to different mental disorders as well as effectiveness studies in everyday practice.     

A probabilistic model of semantic plausibility in sentence processing

Experimental research shows that human sentence processing uses information from different levels of linguistic analysis, for example, lexical and syntactic preferences as well as semantic plausibility. Existing computational models of human sentence processing, however, have focused primarily on lexico-syntactic factors. Those models that do account for semantic plausibility effects lack a general model of human plausibility intuitions at the sentence level. Within a probabilistic framework, we propose a wide-coverage model that both assigns thematic roles to verb–argument pairs and determines a preferred interpretation by evaluating the plausibility of the resulting ( verb , role , argument ) triples. The model is trained on a corpus of role-annotated language data. We also present a transparent integration of the semantic model with an incremental probabilistic parser. We demonstrate that both the semantic plausibility model and the combined syntax/semantics model predict judgment and reading time data from the experimental literature.     

Vom Verhältnis zwischen Psychosomatik und Verhaltensmedizin

Ohne Zusammenfassung     

DEWEX: A system for designing and conducting Web-based experiments

DEWEX is a server-based environment for developing Web-based experiments. It provides many features for creating and running complex experimental designs on a local server. It is freeware and allows for both using default features, for which only text input is necessary, and easy configurations that can be set up by the experimenter. The tool also provides log files on the local server that can be interpreted and analyzed very easily. As an illustration of how DEWEX can be used, a recent study is presented that demonstrates the system’s most important features. This study investigated learning from multiple hypertext sources and shows the influences of task, source of information, and hypertext presentation format on the construction of mental representations of a hypertext about a historical event.