Extinction of drug cue reactivity in methamphetamine-dependent individuals

Conditioned responses to drug-related environmental cues (such as craving) play a critical role in relapse to drug use. Animal models demonstrate that repeated exposure to drug-associated cues in the absence of drug administration leads to the extinction of conditioned responses, but the few existing clinical trials focused on extinction of conditioned responses to drug-related cues in drug-dependent individuals show equivocal results. The current study examined drug-related cue reactivity and response extinction in a laboratory setting in methamphetamine-dependent individuals. Methamphetamine cue-elicited craving was extinguished during two sessions of repeated (3) within-session exposures to multi-modal (picture, video, and in-vivo) cues, with no evidence of spontaneous recovery between sessions. A trend was noted for a greater attenuation of response in participants with longer (4-7 day) inter-session intervals. These results indicate that extinction of drug cue conditioned responding occurs in methamphetamine-dependent individuals, offering promise for the development of extinction- based treatment strategies.     

Music interferes with learning from television during infancy

Infants are frequently exposed to music during daily activities, including free play, and while viewing infant‐directed videotapes that contain instrumental music soundtracks. In Experiment 1, an instrumental music soundtrack was played during a live or televised demonstration to examine its effects on deferred imitation by 6‐, 12‐, and 18‐month‐old infants. Transfer of information was indexed via deferred imitation of the target actions following a 24‐h delay. For half the infants, the music context was also reinstated at the time of test. Performance by experimental groups was compared to that of a baseline control group that participated in the test session without prior exposure to the demonstration. Imitation performance was above baseline for the live groups but not for the video groups regardless of age or the music context at test. In Experiment 2, we added matched sound effects to the video demonstration and infants performed above baseline. We conclude that the music track creates additional cognitive load, disrupts selective attention to the target actions and inhibits transfer of learning from television of the imitation task. Music may impair an infant's ability to translate information from a two‐dimensional to three‐dimensional world even if the auditory context remains the same. Copyright © 2010 John Wiley & Sons, Ltd.     

Determining the influence of tangible items on screaming and handmouthing following an inconclusive functional analysis

A brief experimental analysis was used to compare the effects of the presence of tangible objects in an alone condition following an inconclusive functional analysis of screaming and handmouthing behavior of an 8‐year‐old boy. The alone condition with tangibles involved having toys available throughout the session with no interaction from the therapist and produced a higher percentage of intervals with screaming and handmouthing. The study demonstrates the importance of evaluating the effects of the presence of tangible items during a functional analysis. Copyright © 2004 John Wiley & Sons, Ltd.     

Alexithymia, verbal intellectual deficit, and neurological dysfunction in relation to risk-taking behavior

This study explored relationships between alexithymia (measured through the Toronto Alexithymia Scale), probable neurological dysfunction (Stroop Color Word Test), and “Verbal” and “Abstraction” IQ scores (Hartford-Shipley Institute for Living Scale) in relation to risk-taking behavior. Subjects were “anti-social” risk-takers (criminal offenders undergoing court-related residential drug treatment), “adventurous” risktakers (college students who regularly engage in such sports as rock-climbing and spelunking), or “normals” (college students who were neither adventurous risk-takers nor criminal offenders). Principal findings reveal that clinically relevant alexithymia is observed among risk-takers of either anti-social or adventurous variety less frequently, but among “normals” more frequently, than chance would predict; that the “verbal deficit pattern” in intellectual functioning is observed more frequently among adventurous risk-takers, less frequently among “normals,” and no more frequently among anti-social risk-takers than chance would predict; and that probable neurological dysfunction is observed more frequently among anti-social risk-takers but less frequently among adventurous risk-takers or “normals” than chance would predict. Results support only in part the Pallone-Hennessy (1999) conceptual model of the genesis and correlates of risk-taking in respect of anti-social, but not in respect of adventurous risk-takers. This study was supported by grants from the Henry Rutgers Scholars Program, Rutgers College, and the Fund for Correctional Psychology, Center of Alcohol Studies. Deep gratitude is expressed to Eric Workowski, Charles Rouse, and Joni Lepore for their invaluable assistance.     

BRIEF REPORT Set‐shifting and sensitivity to reward: A possible dopamine mechanism for explaining disinhibitory disorders

The objective of this study was to investigate personality correlates of set‐shifting behaviour using a task sensitive to dopaminergic activity. As expected, set‐shifting behaviour was positively correlated with scores on the Sensitivity to Reward scale, a measure of Gray's impulsivity. Discussion is focused on the relationship between this greater ability for set‐shifting and the proneness to disinhibition.     

A Study of the Use and Interpretation of Standardized Suicide Risk Assessment: Measures within a Psychiatrically Hospitalized Correctional Population

The reliability, validity, and utility of the Adult Suicidal Ideation Questionnaire (ASIQ), Beck Hopelessness Scale (BHS), Beck Scale for Suicide Ideation (BSS), and Reasons for Attempting Suicide Questionnaire (RASQ) with correctional mental health populations was evaluated. Evidence was found indicating good to excellent reliability for all measures. Each of the measures significantly differentiated multiple attempters from single attempters and nonattempters, providing evidence of convergent and divergent validity. Logistic regression and receiver operating characteristic analyses revealed strong associations between multiple attempts and the ASIQ, BSS, and RASQ, but not the BHS. Implications for suicide risk assessment processes in correctional settings are discussed.