Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease.

Nondemented older adults genotyped for the Apolipoprotein E (ApoE) epsilon4 allele (n = 43) were neuropsychologically compared to participants without a copy of the epsilon4 allele (n = 90). At baseline, the groups did not differ on age, education, gender, or global cognitive status. ApoE-epsilon4 participants demonstrated significantly poorer mean performances on delayed recall, but no significant group differences emerged on attention, language, constructional skills, psychomotor speed, or executive function. Significantly more ApoE-epsilon4 participants developed probable or questionable Alzheimer's disease (AD) compared with non-epsilon4 participants, suggesting that the group differences resulted from a preponderance of preclinical AD cases within the epsilon4 group and not from a direct influence of ApoE genotype on cognition. Cox proportional hazards analysis, adjusting for age, years of education, and global cognitive status, revealed that ApoE-epsilon4 allele status and measures of recall performance were significant and independent predictors of conversion to AD. Results support the importance of specific episodic memory changes and possession of the ApoE-epsilon4 allele in the preclinical detection of AD.     

Does infancy matter? predicting social behavior from infant temperament

In this essay we argue that infant temperament, defined as behavioral styles that appear early in life as a direct result of neurobiological factors, plays a significant role in the development and expression of social behavior. Temperament may be studied using a typological or dimensional approach and the relations between early temperament and later behavior can be examined in terms of homotypic or heterotypic continuity. The implication of each of these approaches for understanding the influence of infant temperament on social development is examined. As well, utilizing data from our laboratory, we suggest that under certain circumstances one can predict social behavior by identifying two temperament types in infancy. These types are high reactive/high negative infants and high reactive/high positive infants. A significant proportion of the high reactive/high negative infants display behavioral inhibition and social reticence through the preschool years, whereas a significant proportion of the high reactive/high positive infants display exuberance and positive social interaction through the preschool period.     

Attachment Versus Differentiation: The Contemporary Couple Therapy Debate

This paper reviews the current debate between differentiation and attachment in treating couples through exploring the tenets of crucible therapy (Schnarch, 1991) and emotionally focused couple therapy (Johnson, 2004). We provide a review of the two theories—as well as the two “pure form” example models—and explore the debate in light of the integrative movement in couple and family therapy (Lebow, 2014). We also examine points of convergence of the two theories and models, and provide clinicians and researchers with an enhanced understanding of their divergent positions. Both differentiation and attachment are developmental theories that highlight the human experience of balancing individuality and connection in adulthood. The two models converge in terms of metaconcepts that pervade their respective theories and approach. Both models capitalize on the depth and importance of the therapeutic relationship, and provide rich case conceptualization and processes of therapy. However, they substantially differ in terms of how they view the fundamental aspects of adult development, have vastly divergent approaches to how a therapist intervenes in the room, and different ideas of how a healthy couple should function. In light of the deep polarization of the two models, points of integration—particularly between the broader theories of attachment and differentiation—are offered for therapists to consider.     

The detection of feigned disabilities: the effectiveness of the Personality Assessment Inventory in a traumatized inpatient sample

Research on feigned mental disorders indicates that severe psychopathology coupled with significant trauma histories often complicate feigning determinations, resulting in inaccuracies on otherwise effective measures. As part of malingering assessments, the Personality Assessment Inventory (PAI) is often used because of its excellent validation and the availability of three feigning indicators (Negative Impression, Malingering Index, and Rogers Discriminant Function), which have evidenced large effect sizes and clinically useful cut scores. The current study examined the effectiveness of the PAI in a traumatized inpatient sample using a between-subjects simulation design. Although Negative Impression appeared affected by trauma--especially in conjunction with dissociative symptoms--very positive results were found for Malingering Index and Rogers Discriminant Function. They remained relatively unelevated under honest conditions, despite posttraumatic stress disorder and extensive comorbidity. Using single-point cut scores provided moderately good classification of feigned and genuine PAI profiles. For purposes of classification, the authors operationally defined small indeterminate groups that were considered too close to classify (i.e., ±5T of the cut scores). With indeterminate cases removed, the overall classification rates improved modestly. However, the more important finding involved the error rates for the indeterminate group, which exceeded 50%. Directions for further research are discussed.     

DIFFERENTIAL RESPONDING ACROSS THERAPISTS IN A FUNCTIONAL ANALYSIS: A CASE STUDY

False negative functional analysis (FA) results may be less likely when caregivers serve as therapists, as problem behavior may be more likely to occur in the presence of a caregiver than with a novel therapist. This case study both replicated and extended prior research on this topic. It provides an example of FA results differing between a caregiver and novel therapist and also showed that FA results may differ across caregivers when they serve as therapists. Copyright © 2012 John Wiley & Sons, Ltd.     

Putting the brakes on aggression toward a romantic partner: the inhibitory influence of relationship commitment

Why do people behave aggressively toward romantic partners, and what can put the brakes on this aggression? Provocation robustly predicts aggression in both intimate and nonintimate relationships. Four methodologically diverse studies tested the hypothesis that provocation severity and relationship commitment interact to predict aggression toward one's romantic partner, with the aggression-promoting effects of provocation diminishing as relationship commitment increases. Across all four studies, commitment to one's romantic relationship inhibited aggression toward one's partner when individuals were severely (but not mildly) provoked. Study 4 tested the hypothesis that this Partner Provocation × Commitment interaction effect would be strong among individuals high in dispositional tendencies toward retaliation but weak (perhaps even nonexistent) among individuals low in such tendencies. Discussion emphasizes the importance of understanding instigating, impelling, and inhibiting processes in the perpetration of aggression toward intimate partners.     

Acquaintance and assurance

I criticize Richard Fumerton??s fallibilist acquaintance theory of noninferential justification.     

Birth order, sex of child, and perceptions of parental favoritism

Many studies have examined factors that influence discriminative parental solicitude. Sex, birth order, and age of the mother are a few factors demonstrated to influence levels of parental investment (especially as measured by offspring self-report). One indicator of a high level of parental investment is being a parental favorite. Using self-reports from a sample of several hundred young adults, we secured support for two hypotheses related to the influence of birth order and sex on parental favoritism. Fathers are not perceived as having a favorite child more often than are mothers, but are more likely to favor female children than are mothers. Mothers are perceived to be more likely to favor female children in blended sibships. Both mothers and fathers are perceived as favoring genetically-related children. The results also suggest that the birth order of the parental favorite varies with the birth order of the participant. Firstborns and lastborns report a pattern of favoritism that suggests parents favor firstborn and lastborn children. The discussion addresses limitations of the methodology and presents directions for future research.     

Neural activation underlying cognitive control in the context of neutral and affectively charged pictures in children

The neural correlates of cognitive control for typically developing 9-year-old children were examined using dense-array ERPs and estimates of cortical activation (LORETA) during a go/no-go task with two conditions: a neutral picture condition and an affectively charged picture condition. Activation was estimated for the entire cortex after which data were exported for four regions of interests (ROIs): ventrolateral prefrontal cortex (VLPFC), dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (DLPFC), and orbitofrontal/ventromedial prefrontal cortex (OFC/VMPFC). Results revealed faster reaction times, greater N2 activation, and greater prefrontal activation for the affectively charged picture condition than the neutral picture condition. The findings are discussed in reference to the impact of affective stimuli on recruitment of specific brain regions involved in cognitive control.