Neuropsychological indicators of preclinical Alzheimer’s disease among depressed older adults

Older adults with major depressive disorder (MDD) may also have preclinical Alzheimer’s disease (AD). Differential diagnosis is quite challenging due to the overlapping symptoms of MDD and AD. In the current study, we predicted that impaired long-term memory (an area most affected in early AD), but not executive function (an area affected in MDD and AD), would distinguish older depressed patients who developed AD from those who did not. Patients (N = 120) assessed as having MDD but not dementia at baseline were administered tests of cognitive function and followed longitudinally for subsequent diagnosis of AD. Using structural equation modeling we found a latent construct of long-term memory to be associated with AD to a greater extent than executive functioning. Additional analyses to enhance clinical utility of findings indicated that individual tests of episodic memory were most predictive of AD status. Tests of long-term memory can be utilized by the clinician when assessing for preclinical AD among depressed elderly.     

Does effort influence inequity aversion in cotton-top tamarins (Saguinus oedipus)?

The human sense of fairness entails sensitivity not just to equality, the equal division of resources, but also to merit, the relationship between an individual’s share of resources and how hard they worked for their share. Recent evidence suggests that our sensitivity to equality has deep phylogenetic roots: several nonhuman animal species show an aversion to unequal reward distributions. However, the extent to which nonhuman animals share sensitivity to merit remains poorly understood, largely because previous studies have failed to properly manipulate work effort in inequity aversion tasks. Here, we tested whether cotton-top tamarins (Saguinus oedipus) would exhibit a differential response to inequity when acquiring rewards was either (1) effortful or (2) effortless. Subjects engaged in a pulling task in which they had an opportunity to deliver a disadvantageously unequal distribution of food to themselves and a partner (one piece for self, four pieces for partner). We made delivery effortful by adding a weight to the pulling handle. Critically, effort was calibrated to each individual. Results show that individuals varied markedly in their response to effort, highlighting the importance of manipulating work effort at the individual level. Overall, subjects showed little aversion to inequity. However, subjects were slightly less likely to accept inequity when doing so was effortful, although this effect was pronounced in only one individual. Our findings suggest a new method for capturing individual variation in effort and for studying the roots of the concept of merit in nonhuman animals.     

On predicting others’ words: Electrophysiological evidence of prediction in speech production

The present study investigated whether lexical processes that occur when we name objects can also be observed when an interaction partner is naming objects. We compared the behavioral and electrophysiological responses of participants performing a conditional go/no-go picture naming task in two different conditions: individually and jointly with a confederate participant. To obtain an index of lexical processing, we manipulated lexical frequency, so that half of the pictures had corresponding names of high-frequency and the remaining half had names of low-frequency. Color cues determined whether participants should respond, whether their task-partner should respond, or whether nobody should respond. Behavioral and ERP results showed that participants engaged in lexical processing when it was their turn to respond. Crucially, ERP results on no-go trials revealed that participants also engaged in lexical processing when it was their partner’s turn to act. In addition, ERP results showed increased response inhibition selectively when it was the partner’s turn to act. These findings provide evidence for the claim that listeners generate predictions about speakers’ utterances by relying on their own action production system.     

Do people automatically track others’ beliefs? Evidence from a continuous measure

Recent findings suggest that tracking others’ beliefs is not always effortful and slow, but may rely on a fast and implicit system. An untested prediction of the automatic belief tracking account is that own and others’ beliefs should be activated in parallel. We tested this prediction measuring continuous movement trajectories in a task that required deciding between two possible object locations. We independently manipulated whether participants’ belief about the object location was true or false and whether an onlooker’s belief about the object location was true or false. Manipulating whether or not the agent’s belief was ever task relevant allowed us to compare performance in an explicit and implicit version of the same task. Movement parameters revealed an influence of the onlooker’s irrelevant belief in the implicit version of the task. This provides evidence for parallel activation of own and others’ beliefs.     

Entrepreneurship in young adults: Initial findings from the young entrepreneurs study

The scientific study of youth entrepreneurship is truly in its infancy, with research on the development of entrepreneurship constrained by theoretical foundations that rely on static, trait-like approaches that equate entrepreneurship with stable personality characteristics. In this article, we define entrepreneurship as a fluid process that relies on the bidirectional interplay between a developing individual and his or her context. We report initial findings from the Young Entrepreneurs Study that clarify how entrepreneurial intentions and actions manifest in youth. We present quantitative analyses that examined the relations between entrepreneurial strengths and entrepreneurial activities in a sample of 3461 college students, and we describe the results of semi-structured interviews from a 48-person subset of our larger sample that explored how entrepreneurial intentions and actions manifested in our sample. We describe a mixed-method triangulation that integrates these two sets of findings, then discuss implications for future research.     

Emotion understanding, theory of mind, and prosocial orientation: Relations over time in early childhood

Data were collected when children were 42, 54, and 72 months of age (Ns=210, 191, and 172 for T1, T2, and T3, respectively). Children's emotion understanding (EU) and theory of mind (ToM) were examined as predictors of children's prosocial orientation within and across time. EU positively related to children's sympathy across 2.5 years, and T1 EU positively related to parent-reported prosocial orientation concurrently and across 1 year (T2). T2 ToM positively related to parents' reports of sympathy and prosocial orientation concurrently and 18 months later (T3); in contrast, T3 ToM did not relate to sympathy or prosocial orientation. T2 ToM accounted for marginally significant variance (p<0.058) in T3 mother-reported prosocial orientation over and above that accounted for by T2 prosocial orientation. Fostering the development of EU and ToM may contribute to children's prosocial orientation.     

A ‘WalMartization’ of Religion? The Ecological Impact of Megachurches on the Local and Extra-Local Religious Economy

This study explores the impact megachurches have on local and extra-local congregations. Arguing that the two commonly held theories concerning the effect of megachurches on local congregations—that they are either harmful because they undercut local competition, or are beneficial because they increase local competition—are under-specified, we add the concept of religious niches to an organizational ecology model to predict how megachurches will differentially impact local congregations of various affiliation. Following new methodological directions charted by Blanchard et al. (Soc Forces 86(4):1591–1620, 2008), we test how the presence of megachurches differentially impacts congregational change rates among Catholics, Mainline Protestants, Conservative Protestants and three disaggregated Conservative Protestant sub-groups—Evangelical, Pentecostal and Fundamentalists, using county-level data from the 1990 and 2000 Churches and Church Membership datasets and megachurch data from the Database of Megachurches in the US. We find support for the variable impact of megachurches on local congregations in differing niches. For local congregations in dissimilar niches the presence of megachurches seems to be beneficial, whereas for local congregations inhabiting similar niches the presence of megachurches seems to be harmful. In addition to the local impact of megachurches, we find that they also have an impact upon the vitality of congregations in neighboring counties.     

Hope Against Hope in Cancer at the End of Life

Hope has many facets to it in the context of cancer. This article outlines an instrumental case study for a patient with aggressive lymphoma who rapidly deteriorated to the point of dying. How her and her family’s hope was managed is outlined here from various perspectives. Interviews were carried out with the patient’s family, medical consultant-in-charge (attending physician) and nurses caring for her at the end of life. The findings outline the transition from hope for cure to hope for a good death and the role that the patient and family’s Christian hope played in this. Religiosity and spirituality of hope in terms of Christian hope is explored from the theological perspective. Practical aspects of care in the face of changing hope are discussed. Conclusions are drawn about reframing hope in a changing clinical situation with reference to theories of hope. The importance of acknowledging hope, coping, spirituality and religiosity, especially at end of life, is emphasised.     

Does audiovisual speech offer a fountain of youth for old ears? An event-related brain potential study of age differences in audiovisual speech perception

The current study addressed the question whether audiovisual (AV) speech can improve speech perception in older and younger adults in a noisy environment. Event-related potentials (ERPs) were recorded to investigate age-related differences in the processes underlying AV speech perception. Participants performed an object categorization task in three conditions, namely auditory-only (A), visual-only (V), and AVspeech. Both age groups revealed an equivalent behavioral AVspeech benefit over unisensory trials. ERP analyses revealed an amplitude reduction of the auditory P1 and N1 on AVspeech trials relative to the summed unisensory (A + V) response in both age groups. These amplitude reductions are interpreted as an indication of multisensory efficiency as fewer neural resources were recruited to achieve better performance. Of interest, the observed P1 amplitude reduction was larger in older adults. Younger and older adults also showed an earlier auditory N1 in AVspeech relative to A and A + V trials, an effect that was again greater in the older adults. The degree of multisensory latency shift was predicted by basic auditory functioning (i.e., higher hearing thresholds were associated with larger latency shifts) in both age groups. Together, the results show that AV speech processing is not only intact in older adults, but that the facilitation of neural responses occurs earlier in and to a greater extent than in younger adults. Thus, older adults appear to benefit more from additional visual speech cues than younger adults, possibly to compensate for more impoverished unisensory inputs because of sensory aging.